{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:37:53Z","timestamp":1790743073741,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":866,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["13\/00045"],"award-info":[{"award-number":["13\/00045"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CP 18\/00073"],"award-info":[{"award-number":["CP 18\/00073"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["COV 20\/00181"],"award-info":[{"award-number":["COV 20\/00181"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1111\/ajt.15929","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T01:50:45Z","timestamp":1587088245000},"page":"1849-1858","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":337,"title":["COVID-19 in solid organ transplant recipients: A single-center case series from Spain"],"prefix":"10.1016","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-8001","authenticated-orcid":false,"given":"Mario","family":"Fern\u00e1ndez-Ruiz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0238-1364","authenticated-orcid":false,"given":"Amado","family":"Andr\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Loinaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F.","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5333-7529","authenticated-orcid":false,"given":"Francisco","family":"L\u00f3pez-Medrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3446-1991","authenticated-orcid":false,"given":"Rafael","family":"San Juan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Polanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda D.","family":"Folgueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Lalueza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Lumbreras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Aguado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/ajt.15929_bib1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A novel coronavirus from patients with pneumonia in China, 2019","volume":"382","author":"Zhu","year":"2020","journal-title":"N Engl J Med."},{"key":"10.1111\/ajt.15929_bib2","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0140-6736(20)30251-8","article-title":"Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding","volume":"395","author":"Lu","year":"2020","journal-title":"Lancet."},{"key":"10.1111\/ajt.15929_bib3","unstructured":"World Health Organization (WHO). Coronavirus disease 2019 (COVID-19). Situation Report 67. https:\/\/www.who.int\/docs\/default-source\/coronaviruse\/situation-reports\/20200327-sitrep-67-covid-19.pdf?sfvrsn=b65f68eb_4. Accessed March 28, 2020."},{"key":"10.1111\/ajt.15929_bib4","unstructured":"Instituto de Salud Carlos III, Centro Nacional de Epidemiolog\u00eda. Informe sobre la situaci\u00f3n de COVID-19 en Espa\u00f1a n\u00ba 16 (26 de marzo de 2020). https:\/\/www.isciii.es\/QueHacemos\/Servicios\/VigilanciaSaludPublicaRENAVE\/EnfermedadesTransmisibles\/Documents\/INFORMES\/Informes%20COVID-19\/Informe%20n\u00ba%2016.%20Situaci\u00f3n%20de%20COVID-19%20en%20Espa\u00f1a%20a%2026%20marzo%20de%202020.pdf. Accessed March 28, 2020."},{"key":"10.1111\/ajt.15929_bib5","doi-asserted-by":"crossref","unstructured":"Michaels MG, La Hoz RM, Danziger-Isakov L, et al. Coronavirus disease 2019: implications of emerging infections for transplantation [published online ahead of print 2020]. Am J Transplant. https:\/\/doi.org\/10.1111\/ajt.15832.","DOI":"10.1111\/ajt.15832"},{"key":"10.1111\/ajt.15929_bib6","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet."},{"key":"10.1111\/ajt.15929_bib7","doi-asserted-by":"crossref","unstructured":"Wu C, Chen X, Cai Y, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China[published online ahead of print 2020]. JAMA Intern Med. https:\/\/doi.org\/10.1001\/jamainternmed.2020.0994.","DOI":"10.1001\/jamainternmed.2020.0994"},{"key":"10.1111\/ajt.15929_bib8","doi-asserted-by":"crossref","unstructured":"Young BE, Ong SWX, Kalimuddin S, et al. Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore [published online ahead of print 2020]. JAMA. https:\/\/doi.org\/10.1001\/jama.2020.3204.","DOI":"10.1001\/jama.2020.3204"},{"key":"10.1111\/ajt.15929_bib9","doi-asserted-by":"crossref","unstructured":"Zhu L, Xu X, Ma K, et al. Successful recovery of COVID-19 pneumonia in a renal transplant recipient with long-term immunosuppression [published online ahead of print 2020]. Am J Transplant. https:\/\/doi.org\/10.1111\/ajt.15869.","DOI":"10.1111\/ajt.15869"},{"key":"10.1111\/ajt.15929_bib10","doi-asserted-by":"crossref","unstructured":"Guillen E, Pineiro GJ, Revuelta I, et al. Case report of COVID-19 in a kidney transplant recipient: Does immunosuppression alter the clinical presentation? [published online ahead of print 2020]. Am J Transplant. https:\/\/doi.org\/10.1111\/ajt.15874.","DOI":"10.1111\/ajt.15874"},{"issue":"suppl 7","key":"10.1111\/ajt.15929_bib11","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/1469-0691.12595","article-title":"Influenza and other respiratory virus infections in solid organ transplant recipients","volume":"20","author":"Manuel","year":"2014","journal-title":"Clin Microbiol Infect."},{"key":"10.1111\/ajt.15929_bib12","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1469-0691.2011.03537.x","article-title":"Pandemic influenza A(H1N1) virus infection in solid organ transplant recipients: impact of viral and non-viral co-infection","volume":"18","author":"Cordero","year":"2012","journal-title":"Clin Microbiol Infect."},{"key":"10.1111\/ajt.15929_bib13","doi-asserted-by":"crossref","unstructured":"Mehta P, McAuley DF, Brown M, et al. COVID-19: consider cytokine storm syndromes and immunosuppression [published online ahead of print 2020]. Lancet https:\/\/doi.org\/10.1016\/S0140-6736(20)30628-0.","DOI":"10.1016\/S0140-6736(20)30628-0"},{"key":"10.1111\/ajt.15929_bib14","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1378\/chest.07-0617","article-title":"Comparison of the SpO2\/FiO2 ratio and the PaO2\/FiO2 ratio in patients with acute lung injury or ARDS","volume":"132","author":"Rice","year":"2007","journal-title":"Chest."},{"key":"10.1111\/ajt.15929_bib15","first-page":"2526","article-title":"Acute respiratory distress syndrome: the Berlin Definition","volume":"307","author":"Ranieri","year":"2012","journal-title":"JAMA."},{"key":"10.1111\/ajt.15929_bib16","unstructured":"Ministerio de Sanidad. Centro de Coordinaci\u00f3n de Alertas y Emergencias Sanitarias. Documento t\u00e9cnico de manejo cl\u00ednico de pacientes con enfermedad por el nuevo coronavirus (COVID-19) (versi\u00f3n 3 de Marzo de 2020). https:\/\/www.mscbs.gob.es\/profesionales\/saludPublica\/ccayes\/alertasActual\/nCov-China\/documentos\/Protocolo_manejo_clinico_COVID-19.pdf. Accessed March 21, 2020."},{"key":"10.1111\/ajt.15929_bib17","doi-asserted-by":"crossref","unstructured":"Salehi S, Abedi A, Balakrishnan S, Gholamrezanezhad A. Coronavirus disease 2019 (COVID-19): a systematic review of imaging findings in 919 patients. AJR Am J Roentgenol. 2020:1-7. https:\/\/doi.org\/10.2214\/AJR.20.23034","DOI":"10.2214\/AJR.20.23034"},{"key":"10.1111\/ajt.15929_bib18","doi-asserted-by":"crossref","unstructured":"Martinez MA. Compounds with therapeutic potential against novel respiratory 2019 coronavirus [published online ahead of print 2020]. Antimicrob Agents Chemother. https:\/\/doi.org\/10.1128\/AAC.00399-20.","DOI":"10.1128\/AAC.00399-20"},{"key":"10.1111\/ajt.15929_bib19","doi-asserted-by":"crossref","unstructured":"Yao X, Ye F, Zhang M, et al. In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [published online ahead of print 2020]. Clin Infect Dis. https:\/\/doi.org\/10.1093\/cid\/ciaa237.","DOI":"10.1093\/cid\/ciaa237"},{"key":"10.1111\/ajt.15929_bib20","doi-asserted-by":"crossref","unstructured":"Gautret P, Lagier JC, Parola P, et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial [published online ahead of print 2020]. Int J Antimicrob Agents. https:\/\/doi.org\/10.1016\/j.ijantimicag.2020.105949.","DOI":"10.1016\/j.ijantimicag.2020.105949"},{"key":"10.1111\/ajt.15929_bib21","doi-asserted-by":"crossref","unstructured":"Cao B, Wang Y, Wen D, et al. A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19 [published online ahead of print 2020]. N Engl J Med. https:\/\/doi.org\/10.1056\/NEJMoa2001282.","DOI":"10.1056\/NEJMoa2001282"},{"key":"10.1111\/ajt.15929_bib22","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1053\/jlts.2003.50171","article-title":"Effect of coadministered lopinavir and ritonavir (Kaletra) on tacrolimus blood concentration in liver transplantation patients","volume":"9","author":"Jain","year":"2003","journal-title":"Liver Transpl."},{"key":"10.1111\/ajt.15929_bib23","doi-asserted-by":"crossref","unstructured":"Gandolfini I, Delsante M, Fiaccadori E, et al. COVID-19 in kidney transplant recipients [published online ahead of print 2020]. Am J Transplant. https:\/\/doi.org\/10.1111\/ajt.15891.","DOI":"10.1111\/ajt.15891"},{"key":"10.1111\/ajt.15929_bib24","doi-asserted-by":"crossref","unstructured":"Chen S, Yin Q, Shi H, et al. A familial cluster, including a kidney transplant recipient, of Coronavirus Disease 2019 (COVID-19) in Wuhan, China [published online ahead of print 2020]. Am J Transplant. https:\/\/doi.org\/10.1111\/ajt.15903.","DOI":"10.1111\/ajt.15903"},{"key":"10.1111\/ajt.15929_bib25","doi-asserted-by":"crossref","unstructured":"Huang J, Lin H, Wu Y, et al. COVID-19 in post-transplantation patients - report of two cases [published online ahead of print 2020]. Am J Transplant. https:\/\/doi.org\/10.1111\/ajt.15896.","DOI":"10.1111\/ajt.15896"},{"key":"10.1111\/ajt.15929_bib26","doi-asserted-by":"crossref","unstructured":"Bin L, Yangzhong W, Yuanyuan Z, Huibo S, Fanjun Z, Zhishui C. Successful treatment of severe COVID-19 pneumonia in a liver transplant recipient [published online ahead of print 2020]. Am J Transplant. https:\/\/doi.org\/10.1111\/ajt.15901.","DOI":"10.1111\/ajt.15901"},{"key":"10.1111\/ajt.15929_bib27","doi-asserted-by":"crossref","unstructured":"Seminari E, Colaneri M, Sambo M, et al. Cov2 infection in a renal transplanted patients. A case report [published online ahead of print 2020]. Am J Transplant. https:\/\/doi.org\/10.1111\/ajt.15902.","DOI":"10.1111\/ajt.15902"},{"key":"10.1111\/ajt.15929_bib28","doi-asserted-by":"crossref","unstructured":"Li F, Cai J, Dong N. First cases of COVID-19 in heart transplantation from China [published online ahead of print 2020]. J Heart Lung Transplant. https:\/\/doi.org\/10.1016\/j.healun.2020.03.006.","DOI":"10.1016\/j.healun.2020.03.006"},{"key":"10.1111\/ajt.15929_bib29","doi-asserted-by":"crossref","unstructured":"Antonio R, Silvia M. Immunosuppression drug-related and clinical manifestation of Coronavirus disease 2019: a therapeutical hypothesis [published online ahead of print 2020]. Am J Transplant. https:\/\/doi.org\/10.1111\/ajt.15905.","DOI":"10.1111\/ajt.15905"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajt.15929","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.15929","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajt.15929","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522224216?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522224216?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.15929","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:27:40Z","timestamp":1761629260000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613522224216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S1600613522224216"],"URL":"https:\/\/doi.org\/10.1111\/ajt.15929","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"COVID-19 in solid organ transplant recipients: A single-center case series from Spain","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ajt.15929","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}