{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T08:10:13Z","timestamp":1769760613443,"version":"3.49.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,26]],"date-time":"2020-04-26T00:00:00Z","timestamp":1587859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1111\/ajt.15943","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T02:32:01Z","timestamp":1587954721000},"page":"1896-1901","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Severe COVID-19 in a renal transplant recipient: A focus on pharmacokinetics"],"prefix":"10.1016","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7694-8381","authenticated-orcid":false,"given":"Soufian","family":"Meziyerh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3692-0901","authenticated-orcid":false,"given":"Tom C.","family":"Zwart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald W.","family":"van Etten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen A.","family":"Janson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5980-6947","authenticated-orcid":false,"given":"Teun","family":"van Gelder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian P.J.","family":"Alwayn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan W.","family":"de Fijter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9543-567X","authenticated-orcid":false,"given":"Marlies E.J.","family":"Reinders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk J.A.R.","family":"Moes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-3595","authenticated-orcid":false,"given":"Aiko P.J.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1111\/ajt.15943_bib1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1055\/s-2007-976494","article-title":"Community respiratory virus infections in immunocompromised patients: hematopoietic stem cell and solid organ transplant recipients, and individuals with human immunodeficiency virus infection","volume":"28","author":"Kim","year":"2007","journal-title":"Semin Respir Crit Care Med."},{"key":"10.1111\/ajt.15943_bib2","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12879-016-1492-4","article-title":"Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia","volume":"16","author":"Al Ghamdi","year":"2016","journal-title":"BMC Infect Dis."},{"key":"10.1111\/ajt.15943_bib3","doi-asserted-by":"crossref","unstructured":"D\u2019Antiga L. Coronaviruses and immunosuppressed patients. The facts during the third epidemic [published online ahead of print 2020]. Liver Transpl. 2020. https:\/\/doi.org\/10.1002\/lt.25756.","DOI":"10.1002\/lt.25756"},{"issue":"Pt 11","key":"10.1111\/ajt.15943_bib4","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1099\/vir.0.034983-0","article-title":"Cyclosporin A inhibits the replication of diverse coronaviruses","volume":"92","author":"de Wilde","year":"2011","journal-title":"J Gen Virol."},{"issue":"8","key":"10.1111\/ajt.15943_bib5","doi-asserted-by":"crossref","first-page":"4875","DOI":"10.1128\/AAC.03011-14","article-title":"Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture","volume":"58","author":"de Wilde","year":"2014","journal-title":"Antimicrob Agents Chemother."},{"issue":"9","key":"10.1111\/ajt.15943_bib6","doi-asserted-by":"crossref","first-page":"e343","DOI":"10.1371\/journal.pmed.0030343","article-title":"SARS: systematic review of treatment effects","volume":"3","author":"Stockman","year":"2006","journal-title":"PLoS Medicine."},{"key":"10.1111\/ajt.15943_bib7","unstructured":"Vollaard E, de Boer G, van Dissel S. Drug treatment options for hospitalized patients with COVID-19. https:\/\/web.archive.org\/web\/20200310084722\/https:\/\/lci.rivm.nl\/covid-19\/bijlage\/medicamenteuze-behandelopties. Published 2020. Accessed March 10, 2020."},{"key":"10.1111\/ajt.15943_bib8","doi-asserted-by":"crossref","unstructured":"Zhu L, Xu X, Ma KE, et al. Successful recovery of COVID-19 pneumonia in a renal transplant recipient with long-term immunosuppression [published online ahead of print 2020]. Am J Transplant. 2020. https:\/\/doi.org\/10.1111\/ajt.15869.","DOI":"10.1111\/ajt.15869"},{"key":"10.1111\/ajt.15943_bib9","doi-asserted-by":"crossref","unstructured":"Guillen E, Pineiro GJ, Revuelta I, et al. Case report of COVID-19 in a kidney transplant recipient: does immunosuppression alter the clinical presentation? [published online ahead of print 2020]. Am J Transplant. https:\/\/doi.org\/10.1111\/ajt.15874.","DOI":"10.1111\/ajt.15874"},{"key":"10.1111\/ajt.15943_bib10","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijid.2020.03.022","article-title":"Clinical features and dynamics of viral load in imported and non-imported patients with COVID-19","volume":"94","author":"Xu","year":"2020","journal-title":"Int J Infect Dis."},{"key":"10.1111\/ajt.15943_bib11","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"Guan","year":"2020","journal-title":"N Engl J Med."},{"issue":"17","key":"10.1111\/ajt.15943_bib12","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1056\/NEJMsr2005760","article-title":"Renin-angiotensin-aldosterone system inhibitors in patients with Covid-19","volume":"382","author":"Vaduganathan","year":"2020","journal-title":"N Engl J Med."},{"issue":"5","key":"10.1111\/ajt.15943_bib13","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.kint.2020.03.001","article-title":"The novel coronavirus 2019 epidemic and kidneys","volume":"97","author":"Naicker","year":"2020","journal-title":"Kidney Int."},{"key":"10.1111\/ajt.15943_bib14","doi-asserted-by":"crossref","unstructured":"Cao B, Wang Y, Wen D, et al. A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19. N Engl J Med. 2020. https:\/\/doi.org\/10.1056\/NEJMoa2001282","DOI":"10.1056\/NEJMoa2001282"},{"issue":"11","key":"10.1111\/ajt.15943_bib15","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s40262-012-0007-8","article-title":"Clinical pharmacokinetics and pharmacodynamics of prednisolone and prednisone in solid organ transplantation","volume":"51","author":"Bergmann","year":"2012","journal-title":"Clin Pharmacokinet."},{"issue":"1","key":"10.1111\/ajt.15943_bib16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2165\/00003088-200746010-00002","article-title":"Clinical pharmacokinetics and pharmacodynamics of mycophenolate in solid organ transplant recipients","volume":"46","author":"Staatz","year":"2007","journal-title":"Clin Pharmacokinet."},{"issue":"10","key":"10.1111\/ajt.15943_bib17","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1089\/apc.2012.0169","article-title":"Drug-drug interactions between antiretroviral and immunosuppressive agents in HIV-infected patients after solid organ transplantation: a review","volume":"26","author":"van Maarseveen","year":"2012","journal-title":"AIDS Patient Care STDS."},{"issue":"1","key":"10.1111\/ajt.15943_bib18","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000187007","article-title":"Drug interaction of chloroquine with ciclosporin","volume":"62","author":"Nampoory","year":"1992","journal-title":"Nephron."},{"issue":"2","key":"10.1111\/ajt.15943_bib19","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1159\/000187506","article-title":"Interaction between cyclosporin and chloroquine","volume":"65","author":"Finielz","year":"1993","journal-title":"Nephron."},{"issue":"8","key":"10.1111\/ajt.15943_bib20","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1473-3099(07)70187-1","article-title":"Cardiotoxicity of antimalarial drugs","volume":"7","author":"White","year":"2007","journal-title":"Lancet Infect Dis."}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.15943","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajt.15943","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522224307?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522224307?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.15943","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:28:37Z","timestamp":1761629317000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613522224307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S1600613522224307"],"URL":"https:\/\/doi.org\/10.1111\/ajt.15943","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Severe COVID-19 in a renal transplant recipient: A focus on pharmacokinetics","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ajt.15943","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}