{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T23:51:23Z","timestamp":1787356283621,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1111\/ajt.16005","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T04:51:56Z","timestamp":1589431916000},"page":"123-137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Three-year outcomes from the CRADLE study in de novo pediatric kidney transplant recipients receiving everolimus with reduced tacrolimus and early steroid withdrawal"],"prefix":"10.1016","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6598-6910","authenticated-orcid":false,"given":"Burkhard","family":"T\u00f6nshoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9896-323X","authenticated-orcid":false,"given":"Helio","family":"Tedesco-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Ettenger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Christian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bjerre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Dello Strologo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D.","family":"Marks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3635-6418","authenticated-orcid":false,"given":"Lars","family":"Pape","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udaykiran","family":"Veldandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Cousin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priti","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Meier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"26","key":"10.1111\/ajt.16005_bib1","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1056\/NEJMoa031643","article-title":"Long-term survival of children with end-stage renal disease","volume":"350","author":"McDonald","year":"2004","journal-title":"N Engl J Med."},{"issue":"Suppl 1","key":"10.1111\/ajt.16005_bib2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/ajt.14557","article-title":"OPTN\/SRTR 2016 annual data report: kidney","volume":"18","author":"Hart","year":"2018","journal-title":"Am J Transplant."},{"issue":"4","key":"10.1111\/ajt.16005_bib3","doi-asserted-by":"crossref","first-page":"222","DOI":"10.5500\/wjt.v4.i4.222","article-title":"Challenges in pediatric renal transplantation","volume":"4","author":"Peruzzi","year":"2014","journal-title":"World J Transplant."},{"issue":"8","key":"10.1111\/ajt.16005_bib4","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/j.1399-3046.2010.01403.x","article-title":"Steroid minimization in pediatric renal transplantation: early withdrawal or avoidance?","volume":"14","author":"Grenda","year":"2010","journal-title":"Pediatr Transplant."},{"issue":"1","key":"10.1111\/ajt.16005_bib5","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2215\/CJN.02180314","article-title":"Patterns of growth after kidney transplantation among children with ESRD","volume":"10","author":"Franke","year":"2015","journal-title":"Clin J Am Soc Nephrol."},{"issue":"3","key":"10.1111\/ajt.16005_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0146523","article-title":"Steroid avoidance or withdrawal regimens in paediatric kidney transplantation: a meta-analysis of randomised controlled trials","volume":"11","author":"Zhang","year":"2016","journal-title":"PLoS ONE."},{"issue":"4","key":"10.1111\/ajt.16005_bib7","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1097\/TP.0000000000001320","article-title":"Corticosteroid use and growth after pediatric solid organ transplantation: a systematic review and meta-analysis","volume":"101","author":"Tsampalieros","year":"2017","journal-title":"Transplantation."},{"issue":"7","key":"10.1111\/ajt.16005_bib8","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1399-3046.2007.00735.x","article-title":"Early steroid withdrawal in pediatric renal transplant on newer immunosuppressive drugs","volume":"11","author":"Delucchi","year":"2007","journal-title":"Pediatr Transplant."},{"issue":"12","key":"10.1111\/ajt.16005_bib9","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1007\/s00467-011-1934-6","article-title":"Early steroid withdrawal in pediatric renal transplant: five years of follow-up","volume":"26","author":"Delucchi","year":"2011","journal-title":"Pediatr Nephrol."},{"issue":"4","key":"10.1111\/ajt.16005_bib10","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/j.1600-6143.2010.03047.x","article-title":"A randomized trial to assess the impact of early steroid withdrawal on growth in pediatric renal transplantation: the TWIST study","volume":"10","author":"Grenda","year":"2010","journal-title":"Am J Transplant."},{"issue":"10","key":"10.1111\/ajt.16005_bib11","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1111\/j.1600-6143.2012.04145.x","article-title":"Complete steroid avoidance is effective and safe in children with renal transplants: a multicenter randomized trial with three-year follow-up","volume":"12","author":"Sarwal","year":"2012","journal-title":"Am J Transplant."},{"issue":"6","key":"10.1111\/ajt.16005_bib12","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1097\/TP.0000000000000498","article-title":"Corticosteroid-free kidney transplantation improves growth: 2-year follow-up of the TWIST randomized controlled trial","volume":"99","author":"Webb","year":"2015","journal-title":"Transplantation."},{"issue":"7","key":"10.1111\/ajt.16005_bib13","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1097\/TP.0b013e3182848e03","article-title":"Randomized trial of everolimus-facilitated calcineurin inhibitor minimization over 24 months in renal transplantation","volume":"95","author":"Cibrik","year":"2013","journal-title":"Transplantation."},{"issue":"6","key":"10.1111\/ajt.16005_bib14","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1111\/j.1600-6143.2010.03129.x","article-title":"Everolimus plus reduced-exposure CsA versus mycophenolic acid plus standard-exposure CsA in renal-transplant recipients","volume":"10","author":"Tedesco Silva","year":"2010","journal-title":"Am J Transplant."},{"issue":"11","key":"10.1111\/ajt.16005_bib15","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1111\/ajt.15480","article-title":"Two-year outcomes in de novo renal transplant recipients receiving everolimus-facilitated calcineurin inhibitor reduction regimen from TRANSFORM study","volume":"19","author":"Berger","year":"2019","journal-title":"Am J Transplant."},{"issue":"7","key":"10.1111\/ajt.16005_bib16","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1681\/ASN.2018010009","article-title":"Everolimus with reduced calcineurin inhibitor exposure in renal transplantation","volume":"29","author":"Pascual","year":"2018","journal-title":"J Am Soc Nephrol."},{"issue":"9","key":"10.1111\/ajt.16005_bib17","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/tri.12148","article-title":"Longitudinal growth on an everolimus- versus an MMF-based steroid-free immunosuppressive regimen in paediatric renal transplant recipients","volume":"26","author":"Billing","year":"2013","journal-title":"Transpl Int."},{"issue":"9","key":"10.1111\/ajt.16005_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0135439","article-title":"Efficacy and safety of an everolimus- vs a mycophenolate mofetil-based regimen in pediatric renal transplant recipients","volume":"10","author":"Brunkhorst","year":"2015","journal-title":"PLoS ONE."},{"issue":"6","key":"10.1111\/ajt.16005_bib19","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1097\/TP.0b013e3182295bed","article-title":"Pediatric kidney transplantation followed by de novo therapy with everolimus, low-dose cyclosporine A, and steroid elimination: 3-year data","volume":"92","author":"Pape","year":"2011","journal-title":"Transplantation."},{"issue":"3","key":"10.1111\/ajt.16005_bib20","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/ajt.15081","article-title":"Early conversion of pediatric kidney transplant patients to everolimus with reduced tacrolimus and steroid elimination: results of a randomized trial","volume":"19","author":"T\u00f6nshoff","year":"2019","journal-title":"Am J Transplant."},{"issue":"3","key":"10.1111\/ajt.16005_bib21","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1681\/ASN.2008030287","article-title":"New equations to estimate GFR in children with CKD","volume":"20","author":"Schwartz","year":"2009","journal-title":"J Am Soc Nephrol."},{"key":"10.1111\/ajt.16005_bib22","unstructured":"NAPRTCS. North American Pediatric Renal Trials and Collaborative Studies NAPRTCS: 2014 annual transplant report. 2014."},{"issue":"10","key":"10.1111\/ajt.16005_bib23","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1111\/j.1600-6143.2010.03266.x","article-title":"De novo therapy with everolimus, low-dose ciclosporine A, basiliximab and steroid elimination in pediatric kidney transplantation","volume":"10","author":"Pape","year":"2010","journal-title":"Am J Transplant."},{"issue":"1","key":"10.1111\/ajt.16005_bib24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1600-6143.2009.02767.x","article-title":"A randomized double-blind, placebo controlled trial of steroid withdrawal after pediatric renal transplantation","volume":"10","author":"Benfield","year":"2010","journal-title":"Am J Transplant."},{"issue":"5","key":"10.1111\/ajt.16005_bib25","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1111\/ajt.14090","article-title":"Efficacy and safety of everolimus plus low-dose tacrolimus versus mycophenolate mofetil plus standard-dose tacrolimus in de novo renal transplant recipients: 12-month data","volume":"17","author":"Qazi","year":"2017","journal-title":"Am J Transplant."},{"issue":"9","key":"10.1111\/ajt.16005_bib26","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1111\/ajt.14215","article-title":"Association of clinical events with everolimus exposure in kidney transplant patients receiving low doses of tacrolimus","volume":"17","author":"Shihab","year":"2017","journal-title":"Am J Transplant."},{"issue":"2","key":"10.1111\/ajt.16005_bib27","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/ctr.12045","article-title":"Association of clinical events with everolimus exposure in kidney transplant patients receiving reduced cyclosporine","volume":"27","author":"Shihab","year":"2013","journal-title":"Clin Transplant."},{"issue":"6","key":"10.1111\/ajt.16005_bib28","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s00467-011-1811-3","article-title":"Growth of kidney-transplanted pediatric patients treated with sirolimus","volume":"26","author":"Gonz\u00e1lez","year":"2011","journal-title":"Pediatr Nephrol."},{"issue":"6","key":"10.1111\/ajt.16005_bib29","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1097\/TP.0b013e31819b6d4a","article-title":"Prospective, randomized trial on late steroid withdrawal in pediatric renal transplant recipients under cyclosporine microemulsion and mycophenolate mofetil","volume":"87","author":"H\u00f6cker","year":"2009","journal-title":"Transplantation."},{"issue":"2","key":"10.1111\/ajt.16005_bib30","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/ndt\/gfp506","article-title":"Improved growth and cardiovascular risk after late steroid withdrawal: 2-year results of a prospective, randomised trial in paediatric renal transplantation","volume":"25","author":"Hocker","year":"2010","journal-title":"Nephrol Dial Transplant."},{"issue":"1","key":"10.1111\/ajt.16005_bib31","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/TP.0000000000002726","article-title":"Growth patterns after kidney transplantation in European children over the past 25 years: an ESPN\/ERA-EDTA registry study","volume":"104","author":"Bonthuis","year":"2019","journal-title":"Transplantation."},{"issue":"11","key":"10.1111\/ajt.16005_bib32","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1097\/TP.0000000000001037","article-title":"Pubertal development in pediatric kidney transplant patients receiving mammalian target of rapamycin inhibitors or conventional immunosuppression","volume":"100","author":"Forster","year":"2016","journal-title":"Transplantation."},{"issue":"3","key":"10.1111\/ajt.16005_bib33","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/j.transproceed.2004.09.026","article-title":"Graft function, cardiovascular risk factors, and sex hormones in renal transplant recipients on an immunosuppressive regimen of everolimus, reduced dose of cyclosporine, and basiliximab","volume":"37","author":"Kr\u00e4mer","year":"2005","journal-title":"Transplant Proc."},{"issue":"8","key":"10.1111\/ajt.16005_bib34","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s00467-013-2459-y","article-title":"Long-term side effects of treatment with mTOR inhibitors in children after renal transplantation","volume":"28","author":"Kranz","year":"2013","journal-title":"Pediatr Nephrol."},{"issue":"3","key":"10.1111\/ajt.16005_bib35","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/ajt.13649","article-title":"Impact of everolimus and low-dose cyclosporin on cytomegalovirus replication and disease in pediatric renal transplantation","volume":"16","author":"H\u00f6cker","year":"2016","journal-title":"Am J Transplant."},{"issue":"11","key":"10.1111\/ajt.16005_bib36","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1097\/TP.0b013e31824810e6","article-title":"Review of cytomegalovirus infection findings with mammalian target of rapamycin inhibitor-based immunosuppressive therapy in de novo renal transplant recipients","volume":"93","author":"Nashan","year":"2012","journal-title":"Transplantation."},{"issue":"11","key":"10.1111\/ajt.16005_bib37","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1111\/j.1600-6143.2011.03674.x","article-title":"Cytomegalovirus incidence between everolimus versus mycophenolate in de novo renal transplants: pooled analysis of three clinical trials","volume":"11","author":"Brennan","year":"2011","journal-title":"Am J Transplant."},{"issue":"10","key":"10.1111\/ajt.16005_bib38","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1111\/ajt.13327","article-title":"Reduced incidence of cytomegalovirus infection in kidney transplant recipients receiving everolimus and reduced tacrolimus doses","volume":"15","author":"Tedesco- Silva","year":"2015","journal-title":"Am J Transplant."},{"issue":"6","key":"10.1111\/ajt.16005_bib39","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1111\/ajt.14169","article-title":"Relationship among viremia\/viral infection, alloimmunity, and nutritional parameters in the first year after pediatric kidney transplantation","volume":"17","author":"Ettenger","year":"2017","journal-title":"Am J Transplant."},{"issue":"7","key":"10.1111\/ajt.16005_bib40","doi-asserted-by":"crossref","DOI":"10.1111\/petr.13024","article-title":"Everolimus and reduced calcineurin inhibitor therapy in pediatric liver transplant recipients: results from a multicenter, prospective study","volume":"21","author":"Ganschow","year":"2017","journal-title":"Pediatr Transplant."}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajt.16005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.16005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajt.16005","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S160061352208323X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S160061352208323X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.16005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:32:17Z","timestamp":1761629537000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S160061352208323X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S160061352208323X"],"URL":"https:\/\/doi.org\/10.1111\/ajt.16005","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Three-year outcomes from the CRADLE study in de novo pediatric kidney transplant recipients receiving everolimus with reduced tacrolimus and early steroid withdrawal","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ajt.16005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}