{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:28:36Z","timestamp":1782311316056,"version":"3.54.5"},"reference-count":37,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":531,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["AI132894\u201001"],"award-info":[{"award-number":["AI132894\u201001"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL140470\u20100181"],"award-info":[{"award-number":["HL140470\u20100181"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["RO1DK102912"],"award-info":[{"award-number":["RO1DK102912"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01AR51749"],"award-info":[{"award-number":["R01AR51749"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL116656"],"award-info":[{"award-number":["HL116656"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL135227"],"award-info":[{"award-number":["HL135227"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1111\/ajt.16404","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T22:55:58Z","timestamp":1605826558000},"page":"2067-2078","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["A novel injury site-natural antibody targeted complement inhibitor protects against lung transplant injury"],"prefix":"10.1016","volume":"21","author":[{"given":"Changhai","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunal","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenxiao","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liudmila","family":"Kulik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Alawieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patterson","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Kilkenny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennie","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Gibney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Cantu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Pipkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0748-7590","authenticated-orcid":false,"given":"Tiago","family":"Machuca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Emtiazjoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Goddard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. Michael","family":"Holers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish","family":"Nadig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Christie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Tomlinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0067-0210","authenticated-orcid":false,"given":"Carl","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1111\/ajt.16404_bib1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1164\/rccm.201706-1140OC","article-title":"Quantitative evidence for revising the definition of primary graft dysfunction after lung transplant","volume":"197","author":"Cantu","year":"2018","journal-title":"Am J Respir Crit Care Med."},{"issue":"10","key":"10.1111\/ajt.16404_bib2","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1513\/AnnalsATS.201610-810OC","article-title":"Clinical risk factors and prognostic model for primary graft dysfunction after lung transplantation in patients with pulmonary hypertension","volume":"14","author":"Porteous","year":"2017","journal-title":"Ann Am Thorac Soc."},{"issue":"5","key":"10.1111\/ajt.16404_bib3","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1097\/MOT.0000000000000232","article-title":"Primary graft dysfunction: lessons learned about the first 72 h after lung transplantation","volume":"20","author":"Porteous","year":"2015","journal-title":"Curr Opin Organ Transplant."},{"issue":"12","key":"10.1111\/ajt.16404_bib4","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1164\/rccm.201312-2121LE","article-title":"Plasma complement levels are associated with primary graft dysfunction and mortality after lung transplantation","volume":"189","author":"Shah","year":"2014","journal-title":"Am J Respir Crit Care Med."},{"issue":"17","key":"10.1111\/ajt.16404_bib5","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.138358","article-title":"Local complement activation is associated with primary graft dysfunction after lung transplantation","volume":"5","author":"Kulkarni","year":"2020","journal-title":"JCI Insight."},{"issue":"11","key":"10.1111\/ajt.16404_bib6","doi-asserted-by":"crossref","first-page":"3886","DOI":"10.1073\/pnas.0400347101","article-title":"Identification of a specific self-reactive IgM antibody that initiates intestinal ischemia\/reperfusion injury","volume":"101","author":"Zhang","year":"2004","journal-title":"Proc Natl Acad Sci USA."},{"issue":"1","key":"10.1111\/ajt.16404_bib7","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.yjmcc.2006.02.006","article-title":"The role of natural IgM in myocardial ischemia-reperfusion injury","volume":"41","author":"Zhang","year":"2006","journal-title":"J Mol Cell Cardiol."},{"issue":"13","key":"10.1111\/ajt.16404_bib8","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1161\/CIRCULATIONAHA.114.010482","article-title":"Targeting pathogenic postischemic self-recognition by natural IgM to protect against posttransplantation cardiac reperfusion injury","volume":"131","author":"Atkinson","year":"2015","journal-title":"Circulation."},{"key":"10.1111\/ajt.16404_bib9","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/s12974-015-0464-8","article-title":"Modulation of post-stroke degenerative and regenerative processes and subacute protection by site-targeted inhibition of the alternative pathway of complement","volume":"12","author":"Alawieh","year":"2015","journal-title":"J Neuroinflammation."},{"issue":"3","key":"10.1111\/ajt.16404_bib10","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.4049\/jimmunol.1102132","article-title":"Pathogenic natural antibodies propagate cerebral injury following ischemic stroke in mice","volume":"188","author":"Elvington","year":"2012","journal-title":"J Immunol."},{"issue":"4","key":"10.1111\/ajt.16404_bib11","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1093\/cvr\/cvq141","article-title":"Blockade of self-reactive IgM significantly reduces injury in a murine model of acute myocardial infarction","volume":"87","author":"Haas","year":"2010","journal-title":"Cardiovasc Res."},{"issue":"11","key":"10.1111\/ajt.16404_bib12","doi-asserted-by":"crossref","first-page":"7007","DOI":"10.4049\/jimmunol.1001504","article-title":"Targeted complement inhibitors protect against posttransplant cardiac ischemia and reperfusion injury and reveal an important role for the alternative pathway of complement activation","volume":"185","author":"Atkinson","year":"2010","journal-title":"J Immunol."},{"issue":"9","key":"10.1111\/ajt.16404_bib13","doi-asserted-by":"crossref","first-page":"5363","DOI":"10.4049\/jimmunol.0803980","article-title":"Pathogenic natural antibodies recognizing annexin IV are required to develop intestinal ischemia-reperfusion injury","volume":"182","author":"Kulik","year":"2009","journal-title":"J Immunol."},{"issue":"3","key":"10.1111\/ajt.16404_bib14","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.healun.2013.10.031","article-title":"alpha1-Antitrypsin inhibits ischemia reperfusion-induced lung injury by reducing inflammatory response and cell death","volume":"33","author":"Gao","year":"2014","journal-title":"J Heart Lung Transplant."},{"issue":"6","key":"10.1111\/ajt.16404_bib15","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1165\/rcmb.2018-0224OC","article-title":"Emphysema-associated Autoreactive Antibodies Exacerbate Post-Lung Transplant Ischemia-Reperfusion Injury","volume":"60","author":"Patel","year":"2019","journal-title":"Am J Respir Cell Mol Biol."},{"issue":"9","key":"10.1111\/ajt.16404_bib16","doi-asserted-by":"crossref","first-page":"8489","DOI":"10.18632\/oncotarget.23902","article-title":"Pentraxin 3 deficiency enhances features of chronic rejection in a mouse orthotopic lung transplantation model","volume":"9","author":"Yoshida","year":"2018","journal-title":"Oncotarget."},{"issue":"9","key":"10.1111\/ajt.16404_bib17","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1172\/JCI25208","article-title":"Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection","volume":"115","author":"Atkinson","year":"2005","journal-title":"J Clin Invest."},{"key":"10.1111\/ajt.16404_bib18","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.molimm.2018.06.005","article-title":"Tissue-targeted complement therapeutics","volume":"102","author":"Tomlinson","year":"2018","journal-title":"Mol Immunol."},{"key":"10.1111\/ajt.16404_bib19","doi-asserted-by":"crossref","first-page":"101224","DOI":"10.1016\/j.trim.2019.101224","article-title":"Collagen type-V is a danger signal associated with primary graft dysfunction in lung transplantation","volume":"56","author":"Zaffiri","year":"2019","journal-title":"Transpl Immunol."},{"issue":"10","key":"10.1111\/ajt.16404_bib20","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1111\/ajt.14717","article-title":"Donor pretreatment with nebulized complement C3a receptor antagonist mitigates brain-death induced immunological injury post-lung transplant","volume":"18","author":"Cheng","year":"2018","journal-title":"Am J Transplant."},{"issue":"1","key":"10.1111\/ajt.16404_bib21","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s40472-019-0224-2","article-title":"Role of complement activation in allograft inflammation","volume":"6","author":"Chun","year":"2019","journal-title":"Curr Transplant Rep."},{"issue":"1 Suppl","key":"10.1111\/ajt.16404_bib22","doi-asserted-by":"crossref","first-page":"46S","DOI":"10.1378\/chest.116.suppl_1.46S","article-title":"Complement inhibition attenuates human lung transplant reperfusion injury: a multicenter trial","volume":"116","author":"Zamora","year":"1999","journal-title":"Chest."},{"issue":"2","key":"10.1111\/ajt.16404_bib23","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.jtcvs.2004.06.048","article-title":"A randomized, placebo-controlled trial of complement inhibition in ischemia-reperfusion injury after lung transplantation in human beings","volume":"129","author":"Keshavjee","year":"2005","journal-title":"J Thorac Cardiovasc Surg."},{"issue":"11","key":"10.1111\/ajt.16404_bib24","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1097\/TP.0000000000000034","article-title":"C1-esterase-inhibitor for primary graft dysfunction in lung transplantation","volume":"97","author":"Sommer","year":"2014","journal-title":"Transplantation."},{"key":"10.1111\/ajt.16404_bib25","doi-asserted-by":"crossref","unstructured":"Parquin F, Cuquemelle E, Camps E, et al. C1-esterase inhibitor treatment for antibody-mediated rejection after lung transplantation: two case reports. Eur Respir J. 2020.","DOI":"10.1183\/13993003.02027-2019"},{"issue":"9","key":"10.1111\/ajt.16404_bib26","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1172\/JCI25208","article-title":"Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection","volume":"115","author":"Atkinson","year":"2005","journal-title":"J Clin Invest."},{"issue":"2","key":"10.1111\/ajt.16404_bib27","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.bbrc.2017.06.081","article-title":"C1q\/TNF-related protein 1 promotes endothelial barrier dysfunction under disturbed flow","volume":"490","author":"Liu","year":"2017","journal-title":"Biochem Biophys Res Commun."},{"issue":"1\u20132","key":"10.1111\/ajt.16404_bib28","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11010-016-2842-7","article-title":"C1ql1\/Ctrp14 and C1ql4\/Ctrp11 promote angiogenesis of endothelial cells through activation of ERK1\/2 signal pathway","volume":"424","author":"Liu","year":"2017","journal-title":"Mol Cell Biochem."},{"issue":"1","key":"10.1111\/ajt.16404_bib29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.molimm.2014.01.001","article-title":"Serum MASP-1 in complex with MBL activates endothelial cells","volume":"59","author":"Megyeri","year":"2014","journal-title":"Mol Immunol."},{"key":"10.1111\/ajt.16404_bib30","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2741\/s11","article-title":"Locally produced and activated complement as a mediator of alloreactive T cells","volume":"1","author":"Lalli","year":"2009","journal-title":"Front Biosci (Schol Ed)."},{"issue":"3","key":"10.1111\/ajt.16404_bib31","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.immuni.2008.02.001","article-title":"Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells","volume":"28","author":"Strainic","year":"2008","journal-title":"Immunity."},{"issue":"8","key":"10.1111\/ajt.16404_bib32","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1111\/j.1600-6143.2009.02723.x","article-title":"Primed CD8(+) T-cell responses to allogeneic endothelial cells are controlled by local complement activation","volume":"9","author":"Raedler","year":"2009","journal-title":"Am J Transplant."},{"issue":"1","key":"10.1111\/ajt.16404_bib33","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/MOT.0b013e3283425419","article-title":"Complement regulation of T-cell alloimmunity","volume":"16","author":"Raedler","year":"2011","journal-title":"Curr Opin Organ Transplant."},{"issue":"3","key":"10.1111\/ajt.16404_bib34","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1172\/JCI71359","article-title":"Central memory CD8+ T lymphocytes mediate lung allograft acceptance","volume":"124","author":"Krupnick","year":"2014","journal-title":"J Clin Invest."},{"issue":"1","key":"10.1111\/ajt.16404_bib35","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.cll.2018.10.004","article-title":"Complement and Transplantation: From New Mechanisms to Potential Biomarkers and Novel Treatment Strategies","volume":"39","author":"Horwitz","year":"2019","journal-title":"Clin Lab Med."},{"issue":"2","key":"10.1111\/ajt.16404_bib36","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.ajpath.2011.04.038","article-title":"Complement regulates CD4 T-cell help to CD8 T cells required for murine allograft rejection","volume":"179","author":"Vieyra","year":"2011","journal-title":"Am J Pathol."},{"issue":"6","key":"10.1111\/ajt.16404_bib37","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1172\/JCI61019","article-title":"Antigen-presenting cell-derived complement modulates graft-versus-host disease","volume":"122","author":"Kwan","year":"2012","journal-title":"J Clin Invest."}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.16404","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajt.16404","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522085835?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522085835?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.16404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:34:47Z","timestamp":1761629687000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613522085835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S1600613522085835"],"URL":"https:\/\/doi.org\/10.1111\/ajt.16404","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel injury site-natural antibody targeted complement inhibitor protects against lung transplant injury","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ajt.16404","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}