{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:44:27Z","timestamp":1773099867626,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":470,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1111\/ajt.16599","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T07:58:51Z","timestamp":1617955131000},"page":"2876-2884","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Changes in humoral immune response after SARS-CoV-2 infection in liver transplant recipients compared to immunocompetent patients"],"prefix":"10.1016","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8116-213X","authenticated-orcid":false,"given":"Ar\u00e1nzazu","family":"Caballero-Marcos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1239-5746","authenticated-orcid":false,"given":"Magdalena","family":"Salcedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Alonso-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1795-2919","authenticated-orcid":false,"given":"Manuel","family":"Rodr\u00edguez-Per\u00e1lvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2398-9619","authenticated-orcid":false,"given":"Mar\u00eda","family":"Olmedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0328-8041","authenticated-orcid":false,"given":"Javier","family":"Graus Morales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3086-9463","authenticated-orcid":false,"given":"Valent\u00edn","family":"Cuervas-Mons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0010-4534","authenticated-orcid":false,"given":"Alba","family":"Cachero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1873-0568","authenticated-orcid":false,"given":"Carmelo","family":"Loinaz-Segurola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9180-4693","authenticated-orcid":false,"given":"Mercedes","family":"I\u00f1arrairaegui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6672-5931","authenticated-orcid":false,"given":"Llu\u00eds","family":"Castells","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4265-5019","authenticated-orcid":false,"given":"Sonia","family":"Pascual","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5060-4556","authenticated-orcid":false,"given":"Carmen","family":"Vinaixa-Aun\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7691-5755","authenticated-orcid":false,"given":"Roc\u00edo","family":"Gonz\u00e1lez-Grande","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9016-3705","authenticated-orcid":false,"given":"Alejandra","family":"Otero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Tom\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3585-5733","authenticated-orcid":false,"given":"Javier","family":"Tejedor-Tejada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8503-7552","authenticated-orcid":false,"given":"Jos\u00e9 Mar\u00eda","family":"\u00c1lamo-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1098-3891","authenticated-orcid":false,"given":"Luisa","family":"Gonz\u00e1lez-Di\u00e9guez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2420-1005","authenticated-orcid":false,"given":"Flor","family":"Nogueras-Lopez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4845-5306","authenticated-orcid":false,"given":"Gerardo","family":"Blanco-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6207-7463","authenticated-orcid":false,"given":"Gema","family":"Mu\u00f1oz-Bartolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5280-3038","authenticated-orcid":false,"given":"Francisco Javier","family":"Bustamante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1876-3973","authenticated-orcid":false,"given":"Emilio","family":"F\u00e1brega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1633-2862","authenticated-orcid":false,"given":"Mario","family":"Romero-Crist\u00f3bal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5874-211X","authenticated-orcid":false,"given":"Rosa","family":"Martin-Mateos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Del Rio-Izquierdo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1040-3140","authenticated-orcid":false,"given":"Ana","family":"Arias-Milla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6182-4538","authenticated-orcid":false,"given":"Laura","family":"Calatayud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto A.","family":"Marcacuzco-Quinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4018-9931","authenticated-orcid":false,"given":"V\u00edctor","family":"Fern\u00e1ndez-Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concepci\u00f3n","family":"G\u00f3mez-Gavara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6024-8479","authenticated-orcid":false,"given":"Jordi","family":"Colmenero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5706-5583","authenticated-orcid":false,"given":"Patricia","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4606-1557","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"Pons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1111\/ajt.16599_bib1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1056\/NEJMoa2034545","article-title":"Antibody status and incidence of SARS-CoV-2 infection in health care workers","volume":"384","author":"Lumley","year":"2021","journal-title":"New Eng J Med."},{"issue":"18","key":"10.1111\/ajt.16599_bib2","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1056\/NEJMoa2026116","article-title":"Humoral immune response to SARS-CoV-2 in Iceland","volume":"383","author":"Gudbjartsson","year":"2020","journal-title":"N Engl J Med."},{"issue":"15","key":"10.1111\/ajt.16599_bib3","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1093\/cid\/ciaa310","article-title":"Profiling early humoral response to diagnose novel coronavirus disease (COVID-19)","volume":"71","author":"Guo","year":"2020","journal-title":"Clin Infect Dis."},{"issue":"17","key":"10.1111\/ajt.16599_bib4","first-page":"1695","article-title":"Loss of anti\u2013SARS-CoV-2 antibodies in mild Covid-19","volume":"383","author":"Kutsuna","year":"2020","journal-title":"N Engl J Med."},{"issue":"1","key":"10.1111\/ajt.16599_bib5","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jhep.2020.07.040","article-title":"Epidemiological pattern, incidence, and outcomes of COVID-19 in liver transplant patients","volume":"74","author":"Colmenero","year":"2021","journal-title":"J Hepatol."},{"issue":"9","key":"10.1111\/ajt.16599_bib6","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1093\/aje\/kwy078","article-title":"Implications of the propensity score matching paradox in pharmacoepidemiology","volume":"187","author":"Ripollone","year":"2018","journal-title":"Am J Epidemiol."},{"issue":"10223","key":"10.1111\/ajt.16599_bib7","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan","volume":"395","author":"Huang","year":"2020","journal-title":"China. Lancet."},{"issue":"12","key":"10.1111\/ajt.16599_bib8","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/S1473-3099(20)30634-4","article-title":"Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparison","volume":"20","author":"Ainsworth","year":"2020","journal-title":"Lancet Infect Dis."},{"issue":"18","key":"10.1111\/ajt.16599_bib9","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"Guan","year":"2020","journal-title":"N Engl J Med."},{"key":"10.1111\/ajt.16599_bib10","doi-asserted-by":"crossref","unstructured":"Amaral G, Bushee J, Cordani UG, et al. SARS-CoV-2 infection induces robust, neutralizing antibody responses that are stable for at least three months. medRxiv. 2020. https:\/\/doi.org\/10.1101\/2020.07.14.20151126.","DOI":"10.1101\/2020.07.14.20151126"},{"issue":"6529","key":"10.1111\/ajt.16599_bib11","doi-asserted-by":"crossref","DOI":"10.1126\/science.abf4063","article-title":"Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection","volume":"371","author":"Dan","year":"2021","journal-title":"Science."},{"issue":"7821","key":"10.1111\/ajt.16599_bib12","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41586-020-2456-9","article-title":"Convergent antibody responses to SARS-CoV-2 in convalescent individuals","volume":"584","author":"Robbiani","year":"2020","journal-title":"Nature."},{"issue":"3","key":"10.1111\/ajt.16599_bib13","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1128\/jvi.57.3.1139-1144.1986","article-title":"Effects of cyclosporin A on humoral immune response and resistance against vesicular stomatitis virus in mice","volume":"57","author":"Charan","year":"1986","journal-title":"J Virol."},{"key":"10.1111\/ajt.16599_bib14","doi-asserted-by":"crossref","unstructured":"Benotmane I, Gautier Vargas G, Velay A, et al. Persistence of SARS-CoV-2 antibodies in kidney transplant recipients. Am J Transplant. 2020. https:\/\/doi.org\/10.1111\/ajt.16469. Epub ahead of print.","DOI":"10.1111\/ajt.16469"},{"issue":"2","key":"10.1111\/ajt.16599_bib15","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S1053-2498(01)00335-7","article-title":"Mycophenolate mofetil decreases antibody production after cardiac transplantation","volume":"21","author":"Rose","year":"2002","journal-title":"J Hear Lung Transplant."},{"issue":"4","key":"10.1111\/ajt.16599_bib16","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1053\/jlts.2001.23010","article-title":"Immune response to influenza vaccine in adult liver transplant recipients","volume":"7","author":"Duchini","year":"2001","journal-title":"Liver Transplant."},{"issue":"1","key":"10.1111\/ajt.16599_bib17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/(SICI)1096-9071(200005)61:1<85::AID-JMV14>3.0.CO;2-H","article-title":"Efficacy of influenza vaccination in adult liver transplant recipients","volume":"61","author":"Soesman","year":"2000","journal-title":"J Med Virol."},{"issue":"5","key":"10.1111\/ajt.16599_bib18","doi-asserted-by":"crossref","first-page":"877","DOI":"10.4103\/1319-2442.164556","article-title":"Response of transplant recipients to influenza vaccination based on type of immunosuppression: a meta-analysis","volume":"26","author":"Khedmat","year":"2015","journal-title":"Saudi J Kidney Dis Transpl."},{"issue":"4","key":"10.1111\/ajt.16599_bib19","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.cell.2020.09.038","article-title":"Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity","volume":"183","author":"Rydyznski Moderbacher","year":"2020","journal-title":"Cell."},{"issue":"9","key":"10.1111\/ajt.16599_bib20","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.4049\/jimmunol.2000839","article-title":"Antibody responses to SARS-CoV-2: let\u2019s stick to known knowns","volume":"205","author":"Baumgarth","year":"2020","journal-title":"J Immunol."},{"issue":"4","key":"10.1111\/ajt.16599_bib21","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2020.11.045","article-title":"Protective role of tacrolimus, deleterious role of age and comorbidities in liver transplant recipients with Covid-19: results from the ELITA\/ELTR multi-center European study","volume":"160","author":"Belli","year":"2020","journal-title":"Gastroenterol."},{"issue":"20","key":"10.1111\/ajt.16599_bib22","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1161\/CIRCULATIONAHA.104.510461","article-title":"Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2","volume":"111","author":"Ferrario","year":"2005","journal-title":"Circulation."},{"issue":"10","key":"10.1111\/ajt.16599_bib23","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.3390\/ijms21103474","article-title":"COVID-19 and individual genetic susceptibility\/receptivity: Role of ACE1\/ACE2 genes, immunity, inflammation and coagulation. Might the double x-chromosome in females be protective against SARS-COV-2 compared to the single x-chromosome in males?","volume":"21","author":"Gemmati","year":"2020","journal-title":"Int J Mol Sci."},{"issue":"6","key":"10.1111\/ajt.16599_bib24","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/s41591-020-0897-1","article-title":"Antibody responses to SARS-CoV-2 in patients with COVID-19","volume":"26","author":"Long","year":"2020","journal-title":"Nat Med."},{"issue":"3","key":"10.1111\/ajt.16599_bib25","doi-asserted-by":"crossref","first-page":"e01828","DOI":"10.1128\/JVI.01828-20","article-title":"Changes in SARS-CoV-2 antibody responses impact the estimates of infections in population-based seroprevalence studies","volume":"95","author":"Fenwick","year":"2021","journal-title":"J Virol."}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.16599","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajt.16599","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522086853?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522086853?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.16599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:33:13Z","timestamp":1761629593000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613522086853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S1600613522086853"],"URL":"https:\/\/doi.org\/10.1111\/ajt.16599","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Changes in humoral immune response after SARS-CoV-2 infection in liver transplant recipients compared to immunocompetent patients","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ajt.16599","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}