{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:42:35Z","timestamp":1790354555070,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","award":["173083"],"award-info":[{"award-number":["173083"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1111\/ajt.17151","type":"journal-article","created":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T04:49:35Z","timestamp":1657946975000},"page":"2651-2660","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["An additional dose of viral vector COVID-19 vaccine and mRNA COVID-19 vaccine in kidney transplant recipients: A randomized controlled trial (CVIM 4 study)"],"prefix":"10.1016","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0930-8936","authenticated-orcid":false,"given":"Jackrapong","family":"Bruminhent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chavachol","family":"Setthaudom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pattaraphorn","family":"Phornkittikorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pongsathon","family":"Chaumdee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somsak","family":"Prasongtanakij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supanart","family":"Srisala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumthorn","family":"Malathum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3194-1511","authenticated-orcid":false,"given":"Sarinya","family":"Boongird","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3876-9432","authenticated-orcid":false,"given":"Arkom","family":"Nongnuch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3835-175X","authenticated-orcid":false,"given":"Montira","family":"Assanatham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laor","family":"Nakgul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nutaporn","family":"Sanmeema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angsana","family":"Phuphuakrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4379-4704","authenticated-orcid":false,"given":"Sasisopin","family":"Kiertiburanakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1111\/ajt.17151_bib1","doi-asserted-by":"crossref","first-page":"e0239250","DOI":"10.1371\/journal.pone.0239250","article-title":"Clinical characteristics and risk factors for coronavirus disease 2019 (COVID-19) among patients under investigation in Thailand","volume":"15","author":"Bruminhent","year":"2020","journal-title":"PloS One."},{"issue":"2","key":"10.1111\/ajt.17151_bib2","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1093\/cid\/ciaa863","article-title":"COVID-19 in immunocompromised hosts: what we know so far","volume":"72","author":"Fung","year":"2021","journal-title":"Clin Infect Dis."},{"issue":"6","key":"10.1111\/ajt.17151_bib3","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1097\/TP.0000000000003670","article-title":"Outcomes of COVID-19 in solid organ transplant recipients: a propensity-matched analysis of a large research network","volume":"105","author":"Hadi","year":"2021","journal-title":"Transplantation."},{"issue":"3","key":"10.1111\/ajt.17151_bib4","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/ajt.16867","article-title":"SARS-CoV-2-specific humoral and cell-mediated immune responses after immunization with inactivated COVID-19 vaccine in kidney transplant recipients (CVIM 1 study)","volume":"22","author":"Bruminhent","year":"2022","journal-title":"Am J Transplant."},{"issue":"5","key":"10.1111\/ajt.17151_bib5","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJMoa2035389","article-title":"Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine","volume":"384","author":"Baden","year":"2021","journal-title":"N Engl J Med."},{"issue":"27","key":"10.1111\/ajt.17151_bib6","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1056\/NEJMoa2034577","article-title":"Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine","volume":"383","author":"Polack","year":"2020","journal-title":"N Engl J Med."},{"key":"10.1111\/ajt.17151_bib7","unstructured":"World Health Organization. Interim recommendations for an extended primary series with an additional vaccine dose for COVID-19 vaccination in immunocompromised persons. 2021. 2022 [cited 2022 February 11, 2022]. Available from: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/347079\/WHO-2019-nCoV-Vaccination-SAGE-recommendation-Immunocompromised-persons-2021.1-eng.pdf?sequence=2."},{"issue":"13","key":"10.1111\/ajt.17151_bib8","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1056\/NEJMc2111462","article-title":"Randomized trial of a third dose of mRNA-1273 vaccine in transplant recipients","volume":"385","author":"Hall","year":"2021","journal-title":"N Engl J Med."},{"issue":"7","key":"10.1111\/ajt.17151_bib9","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1056\/NEJMc2108861","article-title":"Three doses of an mRNA Covid-19 vaccine in solid-organ transplant recipients","volume":"385","author":"Kamar","year":"2021","journal-title":"N Engl J Med."},{"issue":"1","key":"10.1111\/ajt.17151_bib10","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1038\/s41598-022-07574-w","article-title":"Immunogenicity of ChAdOx1 nCoV-19 vaccine after a two-dose inactivated SARS-CoV-2 vaccination of dialysis patients and kidney transplant recipients","volume":"12","author":"Bruminhent","year":"2022","journal-title":"Sci Rep."},{"issue":"5","key":"10.1111\/ajt.17151_bib11","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.kint.2021.08.019","article-title":"Risk factors associated with poor response to COVID-19 vaccination in kidney transplant recipients","volume":"100","author":"Azzi","year":"2021","journal-title":"Kidney Int."},{"issue":"2","key":"10.1111\/ajt.17151_bib12","doi-asserted-by":"crossref","first-page":"374","DOI":"10.2215\/CJN.03791106","article-title":"Therapeutic monitoring of calcineurin inhibitors for the nephrologist","volume":"2","author":"Schiff","year":"2007","journal-title":"Clin J Am Soc Nephrol."},{"key":"10.1111\/ajt.17151_bib13","doi-asserted-by":"crossref","first-page":"1256.e9","DOI":"10.1016\/j.cmi.2020.05.036","article-title":"Clinical evaluation of serological IgG antibody response on the Abbott architect for established SARS-CoV-2 infection","volume":"26","author":"Chew","year":"2020","journal-title":"Clin Microbiol Infect."},{"key":"10.1111\/ajt.17151_bib14","unstructured":"SARS-CoV-2 NeutraLISA. 2022 [Cited February 13, 2022]. Available from: https:\/\/www.coronavirus-diagnostics.com\/documents\/Indications\/Infections\/Coronavirus\/EI_2606_D_UK_F.pdf."},{"issue":"3","key":"10.1111\/ajt.17151_bib15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.medj.2021.02.001","article-title":"Persistence of SARS-CoV-2-specific B and T cell responses in convalescent COVID-19 patients 6\u20138 months after the infection","volume":"2","author":"Sherina","year":"2021","journal-title":"Med."},{"issue":"2","key":"10.1111\/ajt.17151_bib16","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1001\/jamainternmed.2021.7372","article-title":"Comparison of SARS-CoV-2 antibody response 4 weeks after homologous vs heterologous third vaccine dose in kidney transplant recipients: a randomized clinical trial","volume":"182","author":"Reindl-Schwaighofer","year":"2022","journal-title":"JAMA Intern Med."},{"issue":"10318","key":"10.1111\/ajt.17151_bib17","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1016\/S0140-6736(21)02717-3","article-title":"Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK(COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial","volume":"398","author":"Munro","year":"2021","journal-title":"Lancet (London, England)."},{"key":"10.1111\/ajt.17151_bib18","first-page":"165","article-title":"Comparison of SARS-CoV-2 antibody response 4 weeks after homologous vs heterologous third vaccine dose in kidney transplant recipients: a randomized clinical trial. JAMA","volume":"182","author":"Reindl-Schwaighofer","year":"2021","journal-title":"Intern Med."},{"key":"10.1111\/ajt.17151_bib19","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1111\/ajt.16966","article-title":"Comparison of the immunogenicity of ChAdOx1 nCoV-19 vaccine against the wild-type and delta variants in kidney transplant recipients and healthy volunteers","volume":"22","author":"Watcharananan","year":"2022","journal-title":"Am J Transplant."},{"issue":"24","key":"10.1111\/ajt.17151_bib20","doi-asserted-by":"crossref","first-page":"13263","DOI":"10.1073\/pnas.230417497","article-title":"Protective long-term antibody memory by antigen-driven and T help-dependent differentiation of long-lived memory B cells to short-lived plasma cells independent of secondary lymphoid organs","volume":"97","author":"Ochsenbein","year":"2000","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"2","key":"10.1111\/ajt.17151_bib21","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/ajt.16851","article-title":"Intensity of mycophenolate mofetil treatment is associated with an impaired immune response to SARS-CoV-2 vaccination in kidney transplant recipients","volume":"22","author":"Kantauskaite","year":"2022","journal-title":"Am J Transplant."},{"issue":"5","key":"10.1111\/ajt.17151_bib22","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1111\/ajt.16990","article-title":"Predictive factors of a viral neutralizing humoral response after a third dose of COVID-19 mRNA vaccine in kidney transplant recipients","volume":"22","author":"Charmetant","year":"2022","journal-title":"Am J Transplant."},{"issue":"12","key":"10.1111\/ajt.17151_bib23","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/s41581-021-00491-7","article-title":"COVID-19 vaccination in kidney transplant recipients","volume":"17","author":"Caillard","year":"2021","journal-title":"Nat Rev Nephrol."},{"issue":"27","key":"10.1111\/ajt.17151_bib24","first-page":"2603","article-title":"Safety and efficacy of the BNT162b2 mRNA Covid-19","volume":"383","author":"Polack","year":"2020","journal-title":"Vaccine."},{"key":"10.1111\/ajt.17151_bib25","unstructured":"Andrews N, Stowe J, Kirsebom F, E, et al. Effectiveness of COVID-19 vaccines against the Omicron (B.1.1.529) variant of concern. 2021: 2021.12.14.21267615."},{"key":"10.1111\/ajt.17151_bib26","unstructured":"Dejnirattisai W, Huo J, Zhou D, et al. Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses. 2021: 2021.12.03.471045."},{"key":"10.1111\/ajt.17151_bib27","first-page":"1","article-title":"SARS-CoV-2 vaccines: safety and immunogenicity in solid organ transplant recipients and strategies for improving vaccine responses","volume":"9","author":"Grupper","year":"2022","journal-title":"Curr Transplant Rep."}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.17151","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajt.17151","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522299808?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522299808?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajt.17151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:39:13Z","timestamp":1761629953000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613522299808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S1600613522299808"],"URL":"https:\/\/doi.org\/10.1111\/ajt.17151","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An additional dose of viral vector COVID-19 vaccine and mRNA COVID-19 vaccine in kidney transplant recipients: A randomized controlled trial (CVIM 4 study)","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/ajt.17151","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2022 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}