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Mast cell functions in response to rapamycin were also measured in the passive systemic anaphylaxis model and bone marrow\u2013derived mast cells (<jats:styled-content style=\"fixed-case\">BMMC<\/jats:styled-content>s).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Daily rapamycin from the first challenge (preventive protocol) attenuated food allergy symptoms including diarrhea, anaphylactic reactions, and hypothermia in mice. The treatment decreased the challenge\u2010induced increases in mouse mast cell protease\u20101 in serum and mast cell numbers in the intestine. Notably, the mice that already showed food allergy symptoms by previous challenges recovered from the disease with daily administration of rapamycin (therapeutic protocol). Anti\u2010<jats:styled-content style=\"fixed-case\">OVA I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>1 and<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>levels in serum, as well as<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3,<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104,<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013,<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20109,<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010, and<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 secretion from splenocytes, were decreased by the treatments. In contrast, a single dose of rapamycin failed to affect passive systemic anaphylaxis. Spontaneous and<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20109\u2010dependent survival and<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\u2010induced<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013 secretion, but not degranulation, of<jats:styled-content style=\"fixed-case\">BMMC<\/jats:styled-content>s were reduced by rapamycin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data show that mouse food allergy was attenuated by rapamycin through an immunosuppressive effect and inhibition of intestinal mast cell hyperplasia. Inhibition of the<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20109 production\u2013mast cell survival axis is one of the mechanisms of the therapeutic effect of rapamycin. Rapamycin and other m<jats:styled-content style=\"fixed-case\">TOR<\/jats:styled-content>inhibitors might be good candidates for therapeutic drugs for food allergy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12000","type":"journal-article","created":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T11:18:48Z","timestamp":1345720728000},"page":"1259-1270","source":"Crossref","is-referenced-by-count":58,"title":["Preventive and therapeutic effects of rapamycin, a mammalian target of rapamycin inhibitor, on food allergy in mice"],"prefix":"10.1111","volume":"67","author":[{"given":"K.","family":"Yamaki","sequence":"first","affiliation":[{"name":"Department of Pharmacology Kobe Pharmaceutical University Kobe Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Kobe Pharmaceutical University Kobe Hyogo 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