{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:48Z","timestamp":1787013828236,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T00:00:00Z","timestamp":1345680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2012,10]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Evidence demonstrates the existence of local allergic rhinitis (\n LAR<\/jats:styled-content>\n ) in nonatopic patients, although its prevalence in the rhinitis population remains unknown. The aim, therefore, of this study was to evaluate the prevalence, clinical characteristics, and severity of\n LAR<\/jats:styled-content>\n in a\n S<\/jats:styled-content>\n panish rhinitis population, compared with patients having classical allergic rhinitis (\n AR<\/jats:styled-content>\n ) with systemic atopy or nonallergic rhinitis (\n NAR<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A group of 452 adult rhinitis patients were randomly selected from a total of 3860 who attended our allergy service over 1\u00a0year. A clinical questionnaire, skin prick test (\n SPT<\/jats:styled-content>\n ), spirometry, and serum total and specific IgE (\n sIgE<\/jats:styled-content>\n ) were evaluated. A nasal allergen provocation test with multiple aeroallergens (NAPT\u2010M), including\n \n D<\/jats:styled-content>\n ermatophagoides pteronyssinus\n <\/jats:italic>\n , pollens,\n alternaria<\/jats:italic>\n , and dog epithelia, was performed in patients with negative SPT and serum\n sIgE<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 428 patients completed the study; 24 were excluded because of nasal hyper\u2010reactivity.\n LAR<\/jats:styled-content>\n was diagnosed in 25.7%,\n AR<\/jats:styled-content>\n in 63.1%, and\n NAR<\/jats:styled-content>\n in 11.2%. The\n LAR<\/jats:styled-content>\n and\n AR<\/jats:styled-content>\n patients had a similar clinical profile: a nonsmoking woman with severe, persistent perennial rhinitis frequently associated with conjunctivitis and asthma. More than 36% of\n LAR<\/jats:styled-content>\n patients reported rhinitis onset in childhood.\n NAPT<\/jats:styled-content>\n \u2010M detected aeroallergen polysensitization in 37.3% of the\n LAR<\/jats:styled-content>\n patients.\n \n D<\/jats:styled-content>\n ermatophagoides pteronyssinus\n <\/jats:italic>\n was the main sensitizing aeroallergen in\n LAR<\/jats:styled-content>\n and\n AR<\/jats:styled-content>\n (60%\n vs<\/jats:italic>\n 54%,\n P\u00a0<\/jats:italic>\n >\n \u00a0<\/jats:italic>\n 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Local allergic rhinitis is a prevalent entity in patients evaluated with rhinitis. Persistent and severe symptoms associated with conjunctivitis and\/or asthma and polysensitization were likely to be detected in\n LAR<\/jats:styled-content>\n and\n AR<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/all.12002","type":"journal-article","created":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T07:18:53Z","timestamp":1345706333000},"page":"1282-1288","source":"Crossref","is-referenced-by-count":145,"title":["Prevalence and clinical relevance of local allergic rhinitis"],"prefix":"10.1111","volume":"67","author":[{"given":"C.","family":"Rond\u00f3n","sequence":"first","affiliation":[{"name":"Allergy Service Carlos Haya Hospital Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Campo","sequence":"additional","affiliation":[{"name":"Allergy Service Carlos Haya Hospital Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Galindo","sequence":"additional","affiliation":[{"name":"Research Laboratory Carlos Haya Hospital\u2010Fundacion IMABIS Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Blanca\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Allergy Service Infanta Leonor Hospital Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"Cassinello","sequence":"additional","affiliation":[{"name":"Allergy Service Carlos Haya Hospital Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Rodriguez\u2010Bada","sequence":"additional","affiliation":[{"name":"Research Laboratory Carlos Haya Hospital\u2010Fundacion IMABIS Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Torres","sequence":"additional","affiliation":[{"name":"Allergy Service Carlos Haya Hospital Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Blanca","sequence":"additional","affiliation":[{"name":"Allergy Service Carlos Haya Hospital Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2745.2002.01465.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01737.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.01.006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01695.x"},{"key":"e_1_2_9_7_1","first-page":"86","article-title":"Seasonal non\u2010allergic rhinitis (SNAR)\u2010a new disease entity? A clinical and immunological comparison between SNAR, seasonal allergic rhinitis and persistent non\u2010allergic rhinitis","volume":"43","author":"Wedb\u00e4ck A","year":"2005","journal-title":"Rhinology"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.07.018"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03492.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)90056-2"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2001.01106.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1398-9995.2003.00315.x"},{"key":"e_1_2_9_13_1","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps 2012","volume":"23","author":"Fokkens WJ","year":"2012","journal-title":"Rhinol Suppl"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.04.006"},{"key":"e_1_2_9_15_1","first-page":"631","volume-title":"Middleton's allergy principles and practice","author":"Demoly P","year":"2003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02728.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.3.7663792"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.06.012"},{"key":"e_1_2_9_19_1","first-page":"3","article-title":"Acoustic rhinometry: recommendations for technical specifications and standard operating procedures","volume":"16","author":"Hilberg O","year":"2000","journal-title":"Rhinol Suppl"},{"issue":"2","key":"e_1_2_9_20_1","first-page":"7","article-title":"Rhinoconjunctivitis Committee of the SEAIC. Epidemiology of allergic rhinitis in allergy consultations in Spain: Alergol\u00f3gica\u20102005","volume":"19","author":"Navarro A","year":"2009","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1998.tb03988.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70370-2"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.118891"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01355.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62896-7"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.12002","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.12002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:42:28Z","timestamp":1695472948000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.12002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,23]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1111\/all.12002"],"URL":"https:\/\/doi.org\/10.1111\/all.12002","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,23]]}}}