{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T15:20:15Z","timestamp":1771168815314,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T00:00:00Z","timestamp":1348531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Caveolin\u20101 has emerged as a critical regulator of signaling pathways involved in lung fibrosis and inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Therefore, we investigated whether caveolin\u20101 is deficient in asthmatic patients and in a murine model of asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Immunohistochemical analyses of endobronchial biopsies showed a remarkable loss of caveolin\u20101 in the lungs of asthmatic patients compared with controls. This loss was most evident in bronchial epithelial cells and associated with an increase in the expression of extracellular matrix proteins: collagen I, tenascin, and periostin. Cultured primary bronchial epithelial cells of asthmatics had lower caveolin\u20101 expression compared with control cells. In addition, caveolin\u20101 expression was significantly decreased in peripheral blood monocytes from asthma patients. The loss of caveolin\u20101 was also observed in a mouse model for asthma (mice sensitized and challenged with aspergillus fumigatus).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To our knowledge, this is the first demonstration that the regulatory protein caveolin\u20101 is reduced in patients with asthma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12021","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T17:37:32Z","timestamp":1348594652000},"page":"1601-1604","source":"Crossref","is-referenced-by-count":31,"title":["Loss of caveolin\u20101 from bronchial epithelial cells and monocytes in human subjects with asthma"],"prefix":"10.1111","volume":"67","author":[{"given":"S. N.","family":"Bains","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Allergy &amp; Critical Care Medicine Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Tourkina","sequence":"additional","affiliation":[{"name":"Division of Rheumatology &amp; Immunology Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Department of Microbiology &amp; Immunology Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Joseph","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Tholanikunnel","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. W.","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Medicine National Jewish Health and the University of Colorado Health Sciences Center Denver CO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. C.","family":"Riemer","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Medicine National Jewish Health and the University of Colorado Health Sciences Center Denver CO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Division of Rheumatology &amp; Immunology Medical University of South Carolina Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.10.6525"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M412551200"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061536"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M701572200"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.117580"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00295.2007"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2010.12.006"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10446670310001598483"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-1536-4-15"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2009.113"},{"key":"e_1_2_9_12_1","first-page":"395","article-title":"Growth factors secreted by bronchial epithelial cells control myofibroblast proliferation: an in vitro co\u2010culture model of airway remodeling in asthma","volume":"79","author":"Zhang S","year":"1999","journal-title":"Lab Invest"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3400"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009426107"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00709.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr067"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.12021","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.12021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T03:40:28Z","timestamp":1697427628000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.12021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,25]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1111\/all.12021"],"URL":"https:\/\/doi.org\/10.1111\/all.12021","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,25]]}}}