{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:12:37Z","timestamp":1791094357252,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,10,4]],"date-time":"2012-10-04T00:00:00Z","timestamp":1349308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2012,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Although unexpected and paradoxical, allergic hypersensitivity to corticosteroids is a common finding, delayed\u2010type reactions being much more frequently encountered than the immediate\u2010type ones. Although the skin is the main sensitization and elicitation route, other routes, amongst them systemic administration of corticosteroids may exceptionally be involved.<\/jats:p><\/jats:sec>Objective<\/jats:title>To determine the frequency, clinical presentation and cross\u2010reactivity patterns for allergic reactions following systemic administration of corticosteroids amongst patients with identified and investigated \u2018contact allergy\u2019 to corticosteroids.<\/jats:p><\/jats:sec>Methods<\/jats:title>We reviewed clinical data, patch test results and sensitization sources in patients who reacted positively to corticosteroids tested in the K<\/jats:styled-content>.U<\/jats:styled-content>. L<\/jats:styled-content>euven D<\/jats:styled-content>ermatology department during an 18\u2010year period.<\/jats:p><\/jats:sec>Results<\/jats:title>Sixteen subjects (out of 315 with CS<\/jats:styled-content> delayed\u2010type hypersensitivity) presented with allergic manifestations due to systemic administration of corticosteroids. Most patients reacted to molecules from the three groups of the recently reappraised classification.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The reactions observed seem to be in most cases \u2018systemic contact dermatitis\u2019 due to oral or parenteral re\u2010exposure of sensitized individuals with the respective corticosteroids previously applied topically. Moreover, most patients seem to be able to react to any corticosteroid molecules and therefore need a systematic individualized evaluation of their sensitization\/tolerance profile.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12041","type":"journal-article","created":{"date-parts":[[2012,10,4]],"date-time":"2012-10-04T07:18:19Z","timestamp":1349335099000},"page":"1580-1585","source":"Crossref","is-referenced-by-count":35,"title":["Systemic contact dermatitis to corticosteroids"],"prefix":"10.1111","volume":"67","author":[{"given":"M.","family":"Baeck","sequence":"first","affiliation":[{"name":"Department of Dermatology Cliniques Universitaires Saint\u2010Luc Universit\u00e9 Catholique de Louvain Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Goossens","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Katholieke Universiteit Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02038.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70024-V"},{"key":"e_1_2_7_4_1","first-page":"354","article-title":"Allergic reactions to topical and systemic corticosteroids","volume":"5","author":"Lauerma AI","year":"1994","journal-title":"Eur J Dermatol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01602.x"},{"key":"e_1_2_7_6_1","unstructured":"MaturaM.Contact Allergy to Locally Applied Corticosteroids. Doctoral Thesis.Leuven:Leuven University Press 1998."},{"key":"e_1_2_7_7_1","first-page":"141","article-title":"Induction of immunological memory in the skin. Role of local T\u2010cell retention","volume":"51","author":"Scheper RJ","year":"1983","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"e_1_2_7_8_1","first-page":"15","article-title":"Retest model: immunological background and practical applications","volume":"46","author":"Jonker M","year":"2002","journal-title":"Contact Dermatitis"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02666.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01874.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01888.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1996.tb02212.x"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.12041","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.12041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T03:39:37Z","timestamp":1697427577000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.12041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,4]]},"references-count":11,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1111\/all.12041"],"URL":"https:\/\/doi.org\/10.1111\/all.12041","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,4]]}}}