{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T17:08:22Z","timestamp":1773162502641,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CRTH<\/jats:styled-content>2 mediates activation of Th2 cells, eosinophils and basophils in response to prostaglandin D<jats:sub>2<\/jats:sub>. The <jats:styled-content style=\"fixed-case\">CRTH<\/jats:styled-content>2 antagonist <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>000459 has previously been demonstrated to reduce airway inflammation and improve lung function in moderate persistent asthma. The objective of the present study was to determine the involvement of <jats:styled-content style=\"fixed-case\">CRTH<\/jats:styled-content>2 in promoting nasal and ocular symptoms in allergic subjects exposed to grass pollen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single centre, randomised, double\u2010blind, placebo\u2010controlled, two\u2010way crossover study was conducted in 35 male subjects allergic to grass pollen comparing <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>000459 200\u00a0mg bid with placebo for 8\u00a0days. Subjects were exposed to grass pollen (\u22651400\u00a0grains\/m<jats:sup>3<\/jats:sup>) for 6\u00a0h on the 2nd and 8th days of treatment and assessed for nasal symptoms, ocular symptoms, other symptoms, nasal secretion weight and rhinomanometry over the 6\u2010h period. After a washout period of 3\u00a0weeks, subjects were switched to the alternative treatment for a further 8\u00a0days. The trial was registered on the clinical trials.gov database (Identifier <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>01448902).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the first treatment period, treatment with <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>000459 significantly reduced both nasal and ocular symptoms in allergic subjects compared with placebo after challenge with grass pollen. A significant effect was observed on the 2nd day of dosing which was increased on the 8th day of dosing. The therapeutic effects of <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>000459 persisted into the second treatment period despite a 3\u2010week washout phase. The safety profile of <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>000459 was similar to that of placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Treatment with <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>000459 was well tolerated and led to a significant and persistent reduction in the symptoms of rhinoconjunctivitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12042","type":"journal-article","created":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T16:35:13Z","timestamp":1349109313000},"page":"1572-1579","source":"Crossref","is-referenced-by-count":80,"title":["The <scp>CRTH<\/scp>2 antagonist <scp>OC<\/scp>000459 reduces nasal and ocular symptoms in allergic subjects exposed to grass pollen, a randomised, placebo\u2010controlled, double\u2010blind trial"],"prefix":"10.1111","volume":"67","author":[{"given":"F.","family":"Horak","sequence":"first","affiliation":[{"name":"Vienna Challenge Chamber Allergy Centre Vienna West Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Zieglmayer","sequence":"additional","affiliation":[{"name":"Vienna Challenge Chamber Allergy Centre Vienna West Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Zieglmayer","sequence":"additional","affiliation":[{"name":"Vienna Challenge Chamber Allergy Centre Vienna West Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Lemell","sequence":"additional","affiliation":[{"name":"Vienna Challenge Chamber Allergy Centre Vienna West Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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