{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T19:29:59Z","timestamp":1770233399233,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T00:00:00Z","timestamp":1350345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recently, a crucial role of Th2 responses in nickel allergic contact dermatitis (<jats:styled-content style=\"fixed-case\">ACD<\/jats:styled-content>) was demonstrated. As palladium allergy is an issue of growing interest, the diagnostic potential of Th2 parameters for palladium sensitization was investigated. Palladium (Na<jats:sub>2<\/jats:sub>[PdCl<jats:sub>4<\/jats:sub>])\u2010induced lymphocyte proliferation (<jats:styled-content style=\"fixed-case\">LPT<\/jats:styled-content>), Th1 and Th2 cytokine production were correlated with skin test (<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>) reactivity in 16 positive and 21 negative controls. Furthermore, the diagnostic potential of these assays was evaluated using receiver operating characteristics (<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) analysis. For comparison, same experiments were carried out for nickel (Ni<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>4<\/jats:sub>). Correlation coefficients between palladium <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content> reactivity and <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3, <jats:styled-content style=\"fixed-case\">LPT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u20105, and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013 were 0.34, 0.51, 0.69, and 0.78, and overall test accuracies were 68%, 81%, 89%, and 95%, respectively. Both palladium\u2010 and nickel\u2010mediated Th2 responses tightly correlate with <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content> reactivity, supporting recent findings on the crucial role of Th2 involvement in <jats:styled-content style=\"fixed-case\">ACD<\/jats:styled-content>. Therefore, these assays may have great potential as diagnostic tools for future <jats:italic>in vitro<\/jats:italic> sensitization testing.<\/jats:p>","DOI":"10.1111\/all.12046","type":"journal-article","created":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T09:38:30Z","timestamp":1350380310000},"page":"1605-1608","source":"Crossref","is-referenced-by-count":20,"title":["Palladium\u2010induced Th2 cytokine responses reflect skin test reactivity"],"prefix":"10.1111","volume":"67","author":[{"given":"J.","family":"Muris","sequence":"first","affiliation":[{"name":"Department of Dental Materials Science Academic Center for Dentistry Amsterdam University of Amsterdam &amp; VU University Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Feilzer","sequence":"additional","affiliation":[{"name":"Department of Dental Materials Science Academic Center for Dentistry Amsterdam University of Amsterdam &amp; VU University Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J.","family":"Kleverlaan","sequence":"additional","affiliation":[{"name":"Department of Dental Materials Science Academic Center for Dentistry Amsterdam University of Amsterdam &amp; VU University Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Rustemeyer","sequence":"additional","affiliation":[{"name":"Department of Dermatology VU University Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. M. W.","family":"van Hoogstraten","sequence":"additional","affiliation":[{"name":"Department of Pathology VU University Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"Scheper","sequence":"additional","affiliation":[{"name":"Department of Pathology VU University Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. M. 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