{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T16:58:49Z","timestamp":1725814729813},"reference-count":9,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T00:00:00Z","timestamp":1350345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The pentavalent antimonials are considered the first\u2010choice drugs for treatment of leishmaniasis. Intralesional therapy is used to minimize the systemic effects of the drug.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy patients were treated with weekly intralesional infiltrations of Glucantime<jats:sup>\u00ae<\/jats:sup> (meglumine antimoniate) for cutaneous leishmaniasis. Nine of them had infiltrated itchy erythematous and vesiculous plaques at the injection sites. Cutaneous tests were undertaken in eight patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prick tests were negative and seven of the eight patients showed positive intradermal tests with Glucantime<jats:sup>\u00ae<\/jats:sup> dilutions reading at D2 and D4. Only one patient had positive patch test to Glucantime a.i. Local reactions at the site of injection have been briefly mentioned in some reported series of leishmaniasis treated with intralesional or intramuscular meglumine antimoniate but the mechanism has never been explained before.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We report the first series of patients with local reactions at the injection sites of meglumine antimoniate in whom type IV hypersensitivity could be involved.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12050","type":"journal-article","created":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T09:38:28Z","timestamp":1350380308000},"page":"1609-1611","source":"Crossref","is-referenced-by-count":9,"title":["Delayed allergic skin reactions due to intralesional meglumine antimoniate therapy for cutaneous leishmaniasis"],"prefix":"10.1111","volume":"67","author":[{"given":"S.","family":"C\u00f3rdoba","sequence":"first","affiliation":[{"name":"Dermatology Hospital Universitario de Fuenlabrada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Gandolfo Cano","sequence":"additional","affiliation":[{"name":"Allergy Hospital Universitario de Fuenlabrada  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Aguado","sequence":"additional","affiliation":[{"name":"Dermatology Hospital Universitario de Fuenlabrada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Huerta\u2010Brogera","sequence":"additional","affiliation":[{"name":"Dermatology Hospital Universitario de Fuenlabrada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Romero","sequence":"additional","affiliation":[{"name":"Dermatology Hospital Universitario de Fuenlabrada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Mart\u00ednez\u2010Mor\u00e1n","sequence":"additional","affiliation":[{"name":"Dermatology Hospital Universitario de Fuenlabrada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Borbujo","sequence":"additional","affiliation":[{"name":"Dermatology Hospital Universitario de Fuenlabrada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,16]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"crossref","unstructured":"GotoH Lauletta LindosoJA.Current diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis.Expert Rev Anti Infect Ther2010;8:419\u2013433.","DOI":"10.1586\/eri.10.19"},{"key":"e_1_2_3_3_1","first-page":"9","article-title":"Les effets ind\u00e9sirables du glucantime par voie g\u00e9n\u00e9rale, dans le traitment de la leishmaniose cutan\u00e9e: a propos de 15 cas","volume":"88","author":"Ezzine Sebai N","year":"2010","journal-title":"La tunisie Medicale"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2009.80.939"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762003000100019"},{"key":"e_1_2_3_6_1","first-page":"93","article-title":"Terap\u00e9utica antileishmania\u202f: revisando el pasado, el presente y el futuro","volume":"117","author":"V\u00e1squez De Ricciardi L","year":"2009","journal-title":"Gac M\u00e9d Caracas"},{"key":"e_1_2_3_7_1","first-page":"4","article-title":"M\u2010CL. Comparaci\u00f3n de tolerabilidad y fisico\u2010qu\u00edmica entre lotes de antimonial comercial y no comercializado (Glucantime\u00ae Vs. Ulamina) en el tratamiento de la leishmaniasis cut\u00e1nea","volume":"12","author":"V\u00e1squez L","year":"2003","journal-title":"MedULA"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03362.x"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.02029.x"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01450.x"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.12050","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.12050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T03:40:32Z","timestamp":1697427632000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.12050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,16]]},"references-count":9,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1111\/all.12050"],"URL":"https:\/\/doi.org\/10.1111\/all.12050","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,16]]}}}