{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:50:29Z","timestamp":1782838229014,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,11,16]],"date-time":"2012-11-16T00:00:00Z","timestamp":1353024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2013,1]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The remodeling patterns in different types of chronic rhinosinusitis (CRS<\/jats:styled-content>) have rarely been compared, particularly the difference between eosinophilic and noneosinophilic CRS<\/jats:styled-content> with nasal polyps (CRS<\/jats:styled-content>wNP<\/jats:styled-content>). Moreover, whether there is a link between remodeling and inflammation remains controversial.<\/jats:p><\/jats:sec>Objective<\/jats:title>To directly compare the remodeling features of different CRS<\/jats:styled-content> and to explore their relationship with inflammation in C<\/jats:styled-content>hinese patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>Histologic characteristics of surgical samples were analyzed in 33 controls, 72 eosinophilic and 76 noneosinophilic CRS<\/jats:styled-content>wNP<\/jats:styled-content>, and 72 CRS<\/jats:styled-content> without nasal polyps (CRS<\/jats:styled-content>sNP<\/jats:styled-content>) patients. Tissue samples from 38 controls, 26 eosinophilic and 26 noneosinophilic CRS<\/jats:styled-content>wNP<\/jats:styled-content>, and 32 CRS<\/jats:styled-content>sNP<\/jats:styled-content> patients were measured for mRNA<\/jats:styled-content> and\/or protein expression of profibrotic growth factors, metalloproteinases (MMP<\/jats:styled-content>s), tissue inhibitor of metalloproteinases (TIMP<\/jats:styled-content>s), hypoxia\u2010inducible factor (HIF<\/jats:styled-content>)\u20101\u03b1, interleukin (IL<\/jats:styled-content>)\u20108, eosinophil cationic protein (ECP<\/jats:styled-content>), and myeloperoxidase (MPO<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>The amount of collagen decreased, whereas the edema scores increased, from CRS<\/jats:styled-content>sNP<\/jats:styled-content> to noneosinophilic CRS<\/jats:styled-content>wNP<\/jats:styled-content> and to eosinophilic CRS<\/jats:styled-content>wNP<\/jats:styled-content>. Transforming growth factor (TGF<\/jats:styled-content>)\u2010\u03b22 protein levels were enhanced in CRS<\/jats:styled-content>sNP<\/jats:styled-content> compared with CRS<\/jats:styled-content>wNP<\/jats:styled-content>. TIMP<\/jats:styled-content>\u20104 protein levels decreased in eosinophilic CRS<\/jats:styled-content>wNP<\/jats:styled-content> compared with noneosinophilic CRS<\/jats:styled-content>wNP<\/jats:styled-content> and CRS<\/jats:styled-content>sNP<\/jats:styled-content>. The number of neutrophils decreased from CRS<\/jats:styled-content>sNP<\/jats:styled-content> to noneosinophilic CRS<\/jats:styled-content>wNP<\/jats:styled-content> and to eosinophilic CRS<\/jats:styled-content>wNP<\/jats:styled-content>. ECP<\/jats:styled-content> levels were only up\u2010regulated in eosinophilic CRS<\/jats:styled-content>wNP<\/jats:styled-content>. ECP<\/jats:styled-content> levels and neutrophil number correlated positively with the severity of edema and fibrosis, respectively. Neutrophils were the major sources of TGF<\/jats:styled-content>\u2010\u03b22 in CRS<\/jats:styled-content>sNP<\/jats:styled-content> and noneosinophilic CRS<\/jats:styled-content>wNP<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Distinct remodeling patterns are revealed for different types of CRS<\/jats:styled-content>, particularly for eosinophilic and noneosinophilic CRS<\/jats:styled-content>wNP<\/jats:styled-content>. Tissue remodeling associates with inflammation in CRS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12064","type":"journal-article","created":{"date-parts":[[2012,11,16]],"date-time":"2012-11-16T10:47:50Z","timestamp":1353062870000},"page":"101-109","source":"Crossref","is-referenced-by-count":136,"title":["Features of airway remodeling in different types of C<\/scp>hinese chronic rhinosinusitis are associated with inflammation patterns"],"prefix":"10.1111","volume":"68","author":[{"given":"L\u2010L.","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 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