{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:06:25Z","timestamp":1700697985228},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,18]],"date-time":"2013-01-18T00:00:00Z","timestamp":1358467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are conflicting study results regarding the association of exposure to visible mould and fungal components in house dust with respiratory and allergic diseases in children. It has been suggested that functional polymorphisms of the <jats:styled-content style=\"fixed-case\"><jats:italic>GSTP1<\/jats:italic><\/jats:styled-content> gene may influence the risk for allergic disorders through an impaired defence against oxidant injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined in six birth cohorts of over 14\u00a0000 children whether the association between early exposure to reported mould at home in relation to respiratory and allergic diseases is modified by a single nucleotide polymorphism of the <jats:styled-content style=\"fixed-case\"><jats:italic>GSTP1<\/jats:italic><\/jats:styled-content> gene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed a positive association of mould exposure with nasal symptoms (2\u201310\u00a0year) <jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>: 1.19 (1.02\u201311.38). Further, there was a borderline significant increased risk of rhinoconjunctivitis (6\u20138\u00a0year) in children homozygous for the minor allele Val\/Val, <jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>: 1.25 (0.98\u20131.60). In stratified analyses, subjects homozygous for the minor allele and exposed to mould at home were at increased risk for early wheezing <jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>: 1.34 (1.03\u20131.75), whereas the major allele may confer susceptibility for later nasal outcomes, (6\u20138\u00a0year) <jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>: 1.20 (1.00\u20131.45) and (2\u201310\u00a0year) <jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>: 1.30 (1.04\u20131.61), respectively. For none of the health outcomes studied, we found gene by environment interactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A genetic influence of the <jats:styled-content style=\"fixed-case\"><jats:italic>GSTP1<\/jats:italic><\/jats:styled-content> gene cannot be ruled out, but the magnitude of the effect is a matter of further research. In conclusion, the interplay between gene and environments is complex and remains subject of further study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12093","type":"journal-article","created":{"date-parts":[[2013,1,18]],"date-time":"2013-01-18T08:02:46Z","timestamp":1358496166000},"page":"339-346","source":"Crossref","is-referenced-by-count":4,"title":["<i>Glutathione\u2010<scp>S<\/scp>\u2010<scp>t<\/scp>ransferase <scp>P<\/scp>1<\/i>, early exposure to mould in relation to respiratory and allergic health outcomes in children from six birth cohorts. A meta\u2010analysis"],"prefix":"10.1111","volume":"68","author":[{"given":"C. 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