{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:38:44Z","timestamp":1788514724431,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nasal polyposis frequently occurs within the clinical picture of aspirin\u2010exacerbated respiratory disease (<jats:styled-content style=\"fixed-case\">AERD<\/jats:styled-content>).<\/jats:p><jats:p>A derailed arachidonic acid metabolism is regarded to be part of the pathophysiology of <jats:styled-content style=\"fixed-case\">AERD<\/jats:styled-content>, and aspirin desensitization is the only causal therapeutic option, so far. The optimal maintenance dose of aspirin desensitization to prevent nasal polyp recurrence on the one hand and to minimize aspirin\u2010related side\u2010effects, on the other hand, is still a matter of debate. The aim of this trial was to investigate the efficacy and safety of a low\u2010dose aspirin desensitization protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After sinus surgery, 70 individuals with <jats:styled-content style=\"fixed-case\">AERD<\/jats:styled-content> were randomly allocated to a prospective double\u2010blind placebo\u2010controlled aspirin desensitization protocol with a maintenance dose of 100\u00a0mg daily. The primary outcome was polyp relapse after 36\u00a0months. Nasal endoscopy status, quality of life, and patients' symptom score as well as aspirin\u2010related side\u2010effects were monitored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Due to the high dropout rate, only 31 individuals were evaluated. After 36\u00a0months, nasal polyp relapse was less frequent (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0785) and the polyposis score was lower (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0702) in the therapy group. Quality of life obviously improved (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0324), clinical complaints (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0083) were significantly reduced, and no severe aspirin\u2010related side\u2010effects were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Aspirin desensitization with a maintenance dose of 100\u00a0mg daily has a positive impact on nasal polyp relapse and seems to be a safe and suitable therapy to improve clinical complaints and the quality of life of individuals with <jats:styled-content style=\"fixed-case\">AERD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12131","type":"journal-article","created":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T07:25:01Z","timestamp":1362641101000},"page":"659-665","source":"Crossref","is-referenced-by-count":98,"title":["Low\u2010dose aspirin desensitization in individuals with aspirin\u2010exacerbated respiratory disease"],"prefix":"10.1111","volume":"68","author":[{"given":"K.","family":"Fruth","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Pogorzelski","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Schmidtmann","sequence":"additional","affiliation":[{"name":"Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI) University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Springer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Fennan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Fraessdorf","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Boessert","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Medical Clinic III Friedrich\u2010Alexander\u2010University Erlangen\u2010Nuremberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gosepath","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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