{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T19:49:22Z","timestamp":1778010562164,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,6,10]],"date-time":"2013-06-10T00:00:00Z","timestamp":1370822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Since the recent establishment of a murine model of eosinophilic chronic rhinosinusitis with nasal polyps (<jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>), both the development of new drugs for treatment or prevention of eosinophilic <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> and elucidation of their pathogenesis have been feasible. We investigated the therapeutic effects of resveratrol on <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> and its mechanism of action using a murine model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After induction of eosinophilic <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>, the therapeutic effects of resveratrol were tested and compared with those of triamcinolone acetonide. Histopathologic changes were evaluated using hematoxylin and eosin for overall inflammation, Sirius red for eosinophils, and Masson's trichrome stain for collagen. The expression levels of the interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20104, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20105, prostaglandin D synthase, and leukotriene C<jats:sub>4<\/jats:sub> synthase genes were assessed by quantitative real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>. Cyclooxygense\u20102 and 5\u2010lipoxygense levels were evaluated by immunohistochemical staining and Western blot analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The degree of eosinophilic infiltration and subepithelial fibrosis was significantly decreased by administration of high\u2010dose resveratrol, the potency of which was similar to that of triamcinolone acetonide. The expression levels of the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20105, prostaglandin D synthase, and leukotriene C<jats:sub>4<\/jats:sub> synthase genes were significantly decreased by administration of low\u2010 or high\u2010dose resveratrol. The production of 5\u2010lipoxygenase was strongly inhibited by high\u2010dose resveratrol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Resveratrol may be useful for the prevention of eosinophilic <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>. A key mechanism of its action is believed to be its anti\u2010inflammatory effect, particularly on eosinophils, by inhibiting the lipoxygenase pathway.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12132","type":"journal-article","created":{"date-parts":[[2013,6,10]],"date-time":"2013-06-10T09:12:40Z","timestamp":1370855560000},"page":"862-869","source":"Crossref","is-referenced-by-count":47,"title":["Resveratrol prevents development of eosinophilic rhinosinusitis with nasal polyps in a mouse model"],"prefix":"10.1111","volume":"68","author":[{"given":"S.\u2010W.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Gyeongsang National University Hospital Jinju South Korea"},{"name":"Institute of Health Sciences Gyeongsang National University Jinju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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H.","family":"Jung","sequence":"additional","affiliation":[{"name":"Clinical Research Institute Gyeongsang National University Hospital Jinju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.\u2010Y.","family":"Chang","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Infectious Diseases Graduate School of Medical Science and Engineering KAIST Daejeon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.\u2010C.","family":"Shin","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Infectious Diseases Graduate School of Medical Science and Engineering KAIST Daejeon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u2010K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Gyeongsang National University Hospital Jinju South 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