{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T16:21:43Z","timestamp":1777998103509,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T00:00:00Z","timestamp":1369180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the associations of folate, homocysteine and vitamin B12 levels of children at birth and their <jats:italic>methylenetetrahydrofolate reductase<\/jats:italic> (<jats:italic><jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content><\/jats:italic>) variants with asthma and eczema in childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was embedded in a population\u2010based prospective cohort study (<jats:italic>n<\/jats:italic>\u00a0=\u00a02,001). Neonatal cord blood folate, homocysteine and vitamin B12 levels were measured, and <jats:italic><jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content><\/jats:italic> <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>677<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>1298<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> genotyped. Wheezing and physician\u2010diagnosed eczema were annually obtained by questionnaire until 4\u00a0years. At 6\u00a0years, we collected information on physician\u2010diagnosed asthma ever and self\u2010reported eczema ever, measured fractional exhaled nitric oxide (<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>e<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>), and interrupter resistance (<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>int). Data were analysed with generalized estimating equations or logistic regression: continuous outcomes with linear regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Folate, homocysteine and vitamin <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>12 levels of children at birth were not associated with wheezing or eczema until 4\u00a0years, asthma and eczema ever, or <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>e<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>int at 6\u00a0years. In children carrying <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>677<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> mutations in <jats:italic><jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content><\/jats:italic>, higher folate levels were associated with an increased risk of eczema (repeated eczema until 4\u00a0years: <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.40 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.09\u20131.80) (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> change) <jats:italic>P<\/jats:italic>\u2010interaction\u00a0=\u00a00.003, eczema ever at 6\u00a0years: <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.41 (0.97\u20132.03) <jats:italic>P<\/jats:italic>\u2010interaction\u00a0=\u00a00.011). No interactions between <jats:italic><jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content><\/jats:italic> and child folate and homocysteine levels were observed for wheezing and asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Folate, homocysteine and vitamin B12 levels of children at birth did not affect asthma\u2010 and eczema\u2010related outcomes up to the age of 6\u00a0years. Further studies are warranted to establish the role of <jats:italic><jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content><\/jats:italic> variants in these associations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12146","type":"journal-article","created":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T09:03:17Z","timestamp":1369213397000},"page":"788-795","source":"Crossref","is-referenced-by-count":31,"title":["Neonatal folate, homocysteine, vitamin <scp>B<\/scp>12 levels and <i>methylenetetrahydrofolate reductase<\/i> variants in childhood asthma and eczema"],"prefix":"10.1111","volume":"68","author":[{"given":"R. J. P.","family":"van der Valk","sequence":"first","affiliation":[{"name":"The Generation R Study Group Erasmus MC Rotterdam The Netherlands"},{"name":"Department of Epidemiology Erasmus MC Rotterdam The Netherlands"},{"name":"Department of Paediatrics Division of Respiratory Medicine Erasmus MC Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"Kiefte\u2010de Jong","sequence":"additional","affiliation":[{"name":"The Generation R Study Group Erasmus MC Rotterdam The Netherlands"},{"name":"Department of Paediatrics Erasmus MC Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M. M.","family":"Sonnenschein\u2010van der Voort","sequence":"additional","affiliation":[{"name":"The Generation R Study Group Erasmus MC Rotterdam The Netherlands"},{"name":"Department of Epidemiology Erasmus MC Rotterdam The Netherlands"},{"name":"Department of Paediatrics Division of Respiratory Medicine Erasmus MC Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Duijts","sequence":"additional","affiliation":[{"name":"The Generation R Study Group Erasmus MC Rotterdam The Netherlands"},{"name":"Department of Epidemiology Erasmus MC Rotterdam The Netherlands"},{"name":"Department of Paediatrics Division of Respiratory Medicine Erasmus MC Rotterdam The Netherlands"},{"name":"Department of Paediatrics Division of Neonatology Erasmus MC Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Hafkamp\u2010de Groen","sequence":"additional","affiliation":[{"name":"The Generation R Study Group Erasmus MC Rotterdam The Netherlands"},{"name":"Department of Public Health Erasmus MC Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. A.","family":"Moll","sequence":"additional","affiliation":[{"name":"The Generation R Study Group Erasmus MC Rotterdam The Netherlands"},{"name":"Department of Paediatrics Erasmus MC Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Tiemeier","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus MC Rotterdam The Netherlands"},{"name":"Department of Child and Adolescent Psychiatry Erasmus MC Rotterdam The Netherlands"},{"name":"Department of Psychiatry Erasmus MC Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. A. 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