{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:48:11Z","timestamp":1791388091510,"version":"4.3.3"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,6,4]],"date-time":"2013-06-04T00:00:00Z","timestamp":1370304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mastocytosis is frequently associated with mast cell\u2010mediated symptoms which require relieving medication. While second generation antihistamines (sg<jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content>s) are the first line therapeutic strategy to treat mast cell mediator\u2010related symptoms, controlled clinical trials on how they improve quality of life have not been performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomized, double\u2010blind, placebo\u2010controlled, cross\u2010over trial assessed rupatadine 20\u00a0mg daily in the treatment of mastocytosis symptoms in 30 adult patients. Symptoms were assessed by a visual analogue scale (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>) and symptom specific quality of life questionnaire (<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>tchy<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>tchy<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> total score and <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> symptom score were significantly improved in the rupatadine treatment phase compared with placebo. There were also significant reductions from placebo in the severity of itch, wheal and flare, flushing, tachycardia and headache but not gastrointestinal symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this first comprehensive trial of a sg<jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content> in mastocytosis, rupatadine 20\u00a0mg daily for 4\u00a0weeks significantly controlled symptoms and improved patients' quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12159","type":"journal-article","created":{"date-parts":[[2013,6,4]],"date-time":"2013-06-04T12:53:28Z","timestamp":1370350408000},"page":"949-952","source":"Crossref","is-referenced-by-count":48,"title":["Rupatadine improves quality of life in mastocytosis: a randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"68","author":[{"given":"F.","family":"Siebenhaar","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Interdisciplinary Mastocytosis Center Charit\u00e9 Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"F\u00f6rtsch","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Interdisciplinary Mastocytosis Center Charit\u00e9 Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Krause","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Interdisciplinary Mastocytosis Center Charit\u00e9 Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Weller","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Interdisciplinary Mastocytosis Center Charit\u00e9 Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Metz","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Interdisciplinary Mastocytosis Center Charit\u00e9 Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Magerl","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Interdisciplinary Mastocytosis Center Charit\u00e9 Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Martus","sequence":"additional","affiliation":[{"name":"Department of Medical Biostatistics Universit\u00e4tsklinikum T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. K.","family":"Church","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Interdisciplinary Mastocytosis Center Charit\u00e9 Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Interdisciplinary Mastocytosis Center Charit\u00e9 Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2007.01807.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000315946"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09434.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.04.006"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(85)90454-1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(93)90076-R"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000249832"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(89)90097-3"},{"key":"e_1_2_8_10_1","first-page":"391","article-title":"Occurrence of platelet\u2010activating factor (PAF) and an endogenous inhibitor of platelet aggregation in diffuse cutaneous mastocytosis","volume":"77","author":"Macpherson JL","year":"1989","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_8_11_1","first-page":"114","article-title":"Rupatadine, a new potent, orally active dual antagonist of histamine and platelet\u2010activating factor (PAF)","volume":"280","author":"Merlos M","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.12.008"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023931"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01330.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10029.x"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.12159","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.12159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T02:10:11Z","timestamp":1696471811000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.12159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,4]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/all.12159"],"URL":"https:\/\/doi.org\/10.1111\/all.12159","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,4]]}}}