{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:37:22Z","timestamp":1790426242314,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,6,7]],"date-time":"2013-06-07T00:00:00Z","timestamp":1370563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Drug hypersensitivity may deprive patients of drug therapy, and occasionally no effective alternative treatment is available. Successful desensitization has been well documented in delayed drug hypersensitivity reactions. In certain situations, such as sulfonamide hypersensitivity in\n                    <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                    \u2010positive patients or hypersensitivity to antibiotics in patients with cystic fibrosis, published success rates reach 80%, and this procedure appears helpful for the patient management. A state of clinical tolerance may be achieved by the administration of increasing doses of the previously offending drug. However, in most cases, a pre\u2010existent sensitization has not been proven by positive skin tests. Successful re\u2010administration may have occurred in nonsensitized patients. A better understanding of the underlying mechanisms of desensitization is needed. Currently, desensitization in delayed hypersensitivity reactions is restricted to mild, uncomplicated exanthems and fixed drug eruptions. The published success rates vary depending on clinical manifestations, drugs, and applied protocols. Slower protocols tend to be more effective than rush protocols; however, underreporting of unsuccessful procedures is very probable. The decision to desensitize a patient must always be made on an individual basis, balancing risks and benefits. This paper reviews the literature and presents the expert experience of the\n                    <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\n                    rug\n                    <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\n                    ypersensitivity\n                    <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\n                    nterest\n                    <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>\n                    roup of the\n                    <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\n                    uropean\n                    <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                    cademy of\n                    <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                    llergy and\n                    <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                    linical\n                    <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\n                    mmunology.\n                  <\/jats:p>","DOI":"10.1111\/all.12161","type":"journal-article","created":{"date-parts":[[2013,6,7]],"date-time":"2013-06-07T08:29:58Z","timestamp":1370593798000},"page":"844-852","source":"Crossref","is-referenced-by-count":186,"title":["Desensitization in delayed drug hypersensitivity reactions \u2013 an\n                    <scp>EAACI<\/scp>\n                    position paper of the Drug Allergy Interest Group"],"prefix":"10.1111","volume":"68","author":[{"given":"K.","family":"Scherer","sequence":"first","affiliation":[{"name":"Allergy Unit Department of Dermatology University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Brockow","sequence":"additional","affiliation":[{"name":"Division Environmental Dermatology and Allergology Helmholtz Zentrum Munich\/TUM Department of Dermatology and Allergology Biederstein Technical University Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Aberer","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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