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Patients lacking eosinophils, in the setting of immunodeficiency or as a consequence of <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>\u2010mediated eosinophil precursor destruction, do not display any distinguishing abnormalities related to eosinophil reduction. The observation that eosinophil\u2010deficient mice do not display any distinctive syndrome or failure of their health is evidence that, under ordinary laboratory conditions, the eosinophil does not play a critical role in the well\u2010being of mammals. Observations that monoclonal antibodies to interleukin\u20105 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20105) are well tolerated appear unsurprising in light of these findings. For example, patients with the hypereosinophilic syndrome have received mepolizumab, an anti\u2010<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20105 monoclonal antibody, for as long as 6\u00a0years and have not developed any characteristic set of adverse events. Safety data for reslizumab, another anti\u2010<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20105 monoclonal antibody, and benralizumab, a monoclonal antibody to the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20105 receptor \u03b1<jats:bold>\u2010<\/jats:bold>chain, are comparatively limited, especially for benralizumab, although reports of administration of these antibodies to humans suggest that they are well tolerated. Thus, data to the present suggest that reduction of eosinophils appears to have no characteristic ill effects on normal health, and monoclonal antibodies that deplete eosinophils have the potential to be widely employed in the treatment of eosinophil\u2010associated diseases.<\/jats:p>","DOI":"10.1111\/all.12169","type":"journal-article","created":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T13:37:13Z","timestamp":1370525833000},"page":"829-835","source":"Crossref","is-referenced-by-count":118,"title":["The consequences of not having eosinophils"],"prefix":"10.1111","volume":"68","author":[{"given":"G. J.","family":"Gleich","sequence":"first","affiliation":[{"name":"University of Utah Health Sciences Center Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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