{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T19:28:25Z","timestamp":1792870105431,"version":"4.5.0"},"reference-count":112,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,8,30]],"date-time":"2013-08-30T00:00:00Z","timestamp":1377820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This year (2013) marks the 50th anniversary of death of Otto Carl Willy Prausnitz (1876\u20131963) and Heinz K\u00fcstner (1897\u20131963). The two physicians, when working at the Hygiene Institute at the University of Breslau, Germany (Prausnitz was the Head of the Institute), described in 1921 what is still called today the Prausnitz\u2013K\u00fcstner or <jats:styled-content style=\"fixed-case\">PK<\/jats:styled-content> reaction showing that allergy could be transferred from the allergic person by transferring serum to a healthy person. Their discovery ended the belief that an anaphylactic\/allergic reaction was caused by poisons, but to the contrary showed that the presence of the hypersensitivity factor could be transferred to other people. We know now that this factor is immunoglobulin E (IgE), sensitizing mast cells and basophils to respond to an allergic stimulus. We take this occasion to retrace some of the important discoveries and lessons learnt from the last century relating to the function of these two cell types as effectors of the IgE system and the mediators they produce.<\/jats:p>","DOI":"10.1111\/all.12197","type":"journal-article","created":{"date-parts":[[2013,8,30]],"date-time":"2013-08-30T12:22:39Z","timestamp":1377865359000},"page":"1093-1101","source":"Crossref","is-referenced-by-count":41,"title":["The history of mast cell and basophil research \u2013 some lessons learnt from the last century"],"prefix":"10.1111","volume":"68","author":[{"given":"U.","family":"Blank","sequence":"first","affiliation":[{"name":"INSERM UMRS 699 Paris France"},{"name":"Laboratoire d'excellence INFLAMEX Sorbonne Paris Cit\u00e9 Universit\u00e9 Paris Diderot Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. H.","family":"Falcone","sequence":"additional","affiliation":[{"name":"Division of Molecular and Cellular Science School of Pharmacy University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Medicine Clinical Immunology and Allergy Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,30]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01930779"},{"key":"e_1_2_13_3_1","first-page":"65 S","volume-title":"I. Teil: Die chemische Auffassung der F\u00e4rbung. II. Teil: Die Anilinfarben in chemischer, technologischer und histologischer Beziehung. Leipzig","author":"Ehrlich P","year":"1878"},{"key":"e_1_2_13_4_1","unstructured":"EhrlichP.Ueber die specifischen Granulationen des Blutes. 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