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We also assessed the induction of multiple <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg cell markers (e.g., <jats:styled-content style=\"fixed-case\">ICOS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> PD<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">GITR<\/jats:styled-content>) on pulmonary <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25<jats:sup>+<\/jats:sup>Foxp3<jats:sup>+<\/jats:sup> cells in the treated mice. Wild\u2010type <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>10 treatments upregulated expression of each marker, while neither <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010\u2010silenced nor <jats:styled-content style=\"fixed-case\">MHCII<\/jats:styled-content><jats:sup>\u2212\/\u2212<\/jats:sup> <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>10 did so, and the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>80\/86<jats:sup>\u2212\/\u2212<\/jats:sup> <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>10 induced an intermediate <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg cell activation phenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 and <jats:styled-content style=\"fixed-case\">MCHII<\/jats:styled-content> expression by <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>10 are requisite, but not sufficient for tolerance induction, suggesting that <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>10 and Th2 effector T cells must be brought together in a cognate fashion in order for their <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 to induce tolerance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12203","type":"journal-article","created":{"date-parts":[[2013,8,2]],"date-time":"2013-08-02T13:39:20Z","timestamp":1375450760000},"page":"1126-1135","source":"Crossref","is-referenced-by-count":23,"title":["Regulatory dendritic cell expression of <scp>MHC<\/scp>II and <scp>IL<\/scp>\u201010 are jointly requisite for induction of tolerance in a murine model of <scp>OVA<\/scp>\u2010asthma"],"prefix":"10.1111","volume":"68","author":[{"given":"H.","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Veterinary Microbiology University of Saskatchewan Saskatoon SK Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Dawicki","sequence":"additional","affiliation":[{"name":"Division of Respirology Critical Care and Sleep Medicine Department of Medicine University of Saskatchewan Saskatoon SK Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Microbiology University of Saskatchewan Saskatoon SK Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Nayyar","sequence":"additional","affiliation":[{"name":"Department of Veterinary Microbiology University of Saskatchewan Saskatoon SK Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Veterinary Microbiology University of Saskatchewan Saskatoon SK Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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