{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:39:46Z","timestamp":1791110386459,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T00:00:00Z","timestamp":1375747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The natural course of childhood asthma and allergy is complex and not fully understood. We aimed to identify phenotypes based upon the time course of respiratory\/allergic symptoms throughout preschool years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>As part of the <jats:styled-content style=\"fixed-case\">PARIS<\/jats:styled-content> cohort, symptoms of wheezing, dry night cough, rhinitis and dermatitis were collected annually from birth to age 4\u00a0years. K\u2010means clustering was used to group into phenotypes children with similar symptoms trajectories over the study period. Associations of phenotypes with IgE sensitization and risk factors were studied using multinomial logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Besides a group with low prevalence of symptoms considered as reference (<jats:italic>n<\/jats:italic>\u00a0=\u00a01236, 49.0%), four distinct respiratory\/allergic phenotypes were identified: two transient [transient rhinitis phenotype (<jats:italic>n<\/jats:italic>\u00a0=\u00a0295, 11.7%), transient wheeze phenotype (<jats:italic>n<\/jats:italic>\u00a0=\u00a0399, 15.8%)], without any relation with IgE sensitization, and two persistent [cough\/rhinitis phenotype (<jats:italic>n<\/jats:italic>\u00a0=\u00a0284, 11.3%), dermatitis phenotype (<jats:italic>n<\/jats:italic>\u00a0=\u00a0308, 12.2%)], associated with IgE sensitization. Transient rhinitis phenotype was only associated with tobacco smoke exposure, which could irritate the airways. Transient wheeze phenotype was related to male sex and contact with other children (older siblings, day care attendance). Lastly, risk factors for both IgE\u2010associated phenotypes encompassed parental history of allergy, potential exposure to allergens and stress, known to be associated with the development of allergic diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provides evidence for the existence of different respiratory\/allergic phenotypes before school age. The fact that they differ in terms of sensitization and risk factors reinforces the plausibility of distinct phenotypes, potentially linked to irritation and infections for the transient phenotypes and to allergy for the persistent phenotypes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12208","type":"journal-article","created":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T17:44:10Z","timestamp":1375811050000},"page":"1158-1167","source":"Crossref","is-referenced-by-count":42,"title":["Onset and persistence of respiratory\/allergic symptoms in preschoolers: new insights from the <scp>PARIS<\/scp> birth cohort"],"prefix":"10.1111","volume":"68","author":[{"given":"F.","family":"Ranci\u00e8re","sequence":"first","affiliation":[{"name":"Univ. Paris Descartes, Sorbonne Paris Cit\u00e9 EA 4064 Laboratoire Sant\u00e9 Publique et Environnement Paris France"},{"name":"Mairie de Paris, Direction de l'Action Sociale de l'Enfance et de la Sant\u00e9 Cellule Cohorte Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Nikasinovic","sequence":"additional","affiliation":[{"name":"Univ. Paris Descartes, Sorbonne Paris Cit\u00e9 EA 4064 Laboratoire Sant\u00e9 Publique et Environnement Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bousquet","sequence":"additional","affiliation":[{"name":"World Health Organization Collaborating Centre for Asthma and Rhinitis Montpellier France"},{"name":"Universit\u00e9 de Montpellier H\u00f4pital Arnaud de Villeneuve Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Momas","sequence":"additional","affiliation":[{"name":"Univ. Paris Descartes, Sorbonne Paris Cit\u00e9 EA 4064 Laboratoire Sant\u00e9 Publique et Environnement Paris France"},{"name":"Mairie de Paris, Direction de l'Action Sociale de l'Enfance et de la Sant\u00e9 Cellule Cohorte Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501193320301"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e32835357ab"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.01.047"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.093187"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.002"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2012.02.016"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200907-1101OC"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-007-9109-2"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08030483"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02467.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.4.9912111"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2011.05.008"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1109\/TPAMI.1979.4766909"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200709-1419OC"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00153507"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2008.00743.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.11.015"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.05.054"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2011.01257.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.4.357"},{"key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1542\/peds.94.6.997","article-title":"Type of day\u2010care setting and risk of repeated infections","volume":"94","author":"Collet JP","year":"1994","journal-title":"Pediatrics"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.12.1119"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22501"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1003222"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.09.050"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200202-158OC"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02712.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00285.x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.319.7213.815"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.01.069"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.1.1"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra074081"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05710.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01751.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2010.05.001"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.12208","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.12208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T16:07:51Z","timestamp":1696522071000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.12208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,6]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1111\/all.12208"],"URL":"https:\/\/doi.org\/10.1111\/all.12208","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,6]]}}}