{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:46:41Z","timestamp":1789616801822,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,9,21]],"date-time":"2013-09-21T00:00:00Z","timestamp":1379721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2013,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Asthma and chronic rhinosinusitis (CRS<\/jats:styled-content>) both impair quality of life, but the quality\u2010of\u2010life impact of comorbid asthma and CRS<\/jats:styled-content> is poorly known. The aim of this study was to evaluate the impact of CRS<\/jats:styled-content> and other relevant factors on quality of life in asthmatic subjects.<\/jats:p><\/jats:sec>Methods<\/jats:title>This Swedish cohort (age 17\u201376\u00a0years) consists of 605 well\u2010characterized asthmatics with and without CRS<\/jats:styled-content>, 110 individuals with CRS<\/jats:styled-content> only, and 226 controls and is part of the G<\/jats:styled-content>lobal A<\/jats:styled-content>llergy and A<\/jats:styled-content>sthma E<\/jats:styled-content>uropean N<\/jats:styled-content>etwork (GA<\/jats:styled-content>2<\/jats:sup>LEN<\/jats:styled-content>) survey. The Mini A<\/jats:styled-content>sthma Q<\/jats:styled-content>uality of L<\/jats:styled-content>ife Q<\/jats:styled-content>uestionnaire (mAQLQ<\/jats:styled-content>), the E<\/jats:styled-content>uro Q<\/jats:styled-content>uality of L<\/jats:styled-content>ife (EQ<\/jats:styled-content>\u20105D<\/jats:styled-content>) health questionnaire, spirometry, skin prick test (SPT), exhaled nitric oxide (F<\/jats:styled-content>eNO<\/jats:styled-content>), smell test, and peak nasal inspiratory flow were used.<\/jats:p><\/jats:sec>Results<\/jats:title>Subjects having both asthma and CRS<\/jats:styled-content> have lower mAQLQ<\/jats:styled-content> scores in all domains (P<\/jats:styled-content><\/jats:italic>\u00a0<\u00a00.001) and a lower EQ<\/jats:styled-content>\u20105D<\/jats:styled-content> index value and EQ<\/jats:styled-content>\u20105D VAS<\/jats:styled-content> value (P<\/jats:styled-content><\/jats:italic>\u00a0<\u00a00.001) compared to those with asthma only. Asthmatics with CRS<\/jats:styled-content> have significantly lower FEV<\/jats:styled-content>1%pred and FVC<\/jats:styled-content>%pred (88.4 [85.1\u201391.7] and 99.9 [96.7\u2013103.0], respectively) compared with asthma only (91.9 [90.3\u201393.4] and 104.0 [102.5\u2013105.5], respectively P<\/jats:styled-content><\/jats:italic>\u00a0<\u00a00.05). Multiple regression analysis shows that low asthma quality of life is associated with having CRS<\/jats:styled-content> (P<\/jats:styled-content><\/jats:italic>\u00a0<\u00a00.0001), lower lung function (P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.008), current smoking (P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.01), BMI<\/jats:styled-content>\u00a0>\u00a030\u00a0kg\/m2<\/jats:sup> (P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.04), high age (P\u00a0<\/jats:italic><\/jats:styled-content>=\u00a00.03), and a negative SPT<\/jats:styled-content> (P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.04).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Comorbid CRS<\/jats:styled-content> was a significant and independent negative predictor of quality of life in asthmatics. Other negative factors were lower lung function, current smoking, obesity, advanced age, and having nonatopic asthma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12222","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T21:49:46Z","timestamp":1381528186000},"page":"1314-1321","source":"Crossref","is-referenced-by-count":85,"title":["Chronic rhinosinusitis in asthma is a negative predictor of quality of life: results from the S<\/scp>wedish GA<\/scp>2<\/sup>LEN<\/scp> survey"],"prefix":"10.1111","volume":"68","author":[{"given":"A.","family":"Ek","sequence":"first","affiliation":[{"name":"Experimental Asthma and Allergy Research Unit Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J. M.","family":"Middelveld","sequence":"additional","affiliation":[{"name":"The Centre for Allergy Research and Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Bertilsson","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine: Occupational and Environmental Medicine Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bjerg","sequence":"additional","affiliation":[{"name":"Krefting Research Centre Department of Internal Medicine and Clinical Nutrition Sahlgrenska Academy University of Gothenburg G\u00f6teborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Ekerljung","sequence":"additional","affiliation":[{"name":"Krefting Research Centre Department of Internal Medicine and Clinical Nutrition Sahlgrenska Academy University of Gothenburg 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