{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:14:25Z","timestamp":1791274465753,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T00:00:00Z","timestamp":1384128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prospective studies investigating the role of serum vitamin E concentrations during early life in the development of childhood allergies and asthma are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the associations between serum vitamin E concentrations at first year of life and longitudinal development of atopy, atopic dermatitis, wheeze, and asthma up to 6\u00a0years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The setting was the <jats:styled-content style=\"fixed-case\">PASTURE<\/jats:styled-content> study, a multicenter prospective birth cohort study in five European rural settings. Children of 1133 mothers recruited during pregnancy were followed from birth with measurement of serum vitamin E levels at year 1 and repeated assessments of serum immunoglobulin E antibodies (year 1, 4.5, 6), atopic dermatitis, wheezing symptoms, and asthma (year 1, 1.5, 2, 3, 4, 5, 6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 6\u00a0years of age, 66% and 82% of the original 1133 subjects underwent blood test for IgE and answered the questionnaire, respectively. We did not observe any statistically significant associations between serum vitamin E concentrations at year 1 and the endpoints, but borderline inverse associations between alpha tocopherol and wheezing without cold (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.45, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.19\u20131.09) and any wheezing symptom (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.52, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.27\u20131.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum vitamin E concentrations at year 1 were not associated with allergies or asthma by 6\u00a0years of age. While further prospective studies with repeated assessments of vitamin E during early life may clarify its putative role in the development of the diseases, it is also possible that the antioxidant hypothesis in the development of allergies and asthma does not hold.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12307","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T08:08:51Z","timestamp":1384157331000},"page":"87-94","source":"Crossref","is-referenced-by-count":28,"title":["Serum vitamin E concentrations at 1\u00a0year and risk of atopy, atopic dermatitis, wheezing, and asthma in childhood: the <scp>PASTURE<\/scp> study"],"prefix":"10.1111","volume":"69","author":[{"given":"B. I.","family":"Nwaru","sequence":"first","affiliation":[{"name":"School of Health Sciences University of Tampere Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M.","family":"Virtanen","sequence":"additional","affiliation":[{"name":"School of Health Sciences University of Tampere Tampere Finland"},{"name":"Nutrition Unit Department of Lifestyle and Participation National Institute for Health and Welfare Helsinki Finland"},{"name":"The Science Center of Pirkanmaa Hospital District Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Alfthan","sequence":"additional","affiliation":[{"name":"Disease Risk Unit Department of Chronic Disease Prevention National Institute for Health and Welfare Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Karvonen","sequence":"additional","affiliation":[{"name":"Department of Environmental Health National Institute for Health and Welfare Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Genuneit","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Medical Biometry Ulm University Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. P.","family":"Lauener","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Switzerland St. Gallen, and Christine K\u00fchne\u2010Center for Allergy Research and Education Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010C.","family":"Dalphin","sequence":"additional","affiliation":[{"name":"Department of Respiratory Disease UMR\/CNRS 6249 Chrono\u2010environnement University Hospital of Besan\u00e7on Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hyv\u00e4rinen","sequence":"additional","affiliation":[{"name":"Department of Environmental Health National Institute for Health and Welfare Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Pfefferle","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Molecular Diagnostics Philipps University of Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Riedler","sequence":"additional","affiliation":[{"name":"Children's Hospital Schwarzach Schwarzach Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Weber","sequence":"additional","affiliation":[{"name":"University Children's Hospital Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Roduit","sequence":"additional","affiliation":[{"name":"Christine K\u00fchne\u2010Center for Allergy Research and Education Z\u00fcrich University Children's Hospital Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Kaulek","sequence":"additional","affiliation":[{"name":"Department of Respiratory Disease UMR\/CNRS 6249 Chrono\u2010environnement University Hospital of Besan\u00e7on Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Braun\u2010Fahrl\u00e4nder","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute Basel Switzerland"},{"name":"University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"von Mutius","sequence":"additional","affiliation":[{"name":"University Children's Hospital Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Pekkanen","sequence":"additional","affiliation":[{"name":"Department of Environmental Health National Institute for Health and Welfare Kuopio Finland"},{"name":"Unit of Public Health and Clinical Nutrition University of Eastern Finland Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the PASTURE study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.49.2.171"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1079\/PHN2003543","article-title":"A review of the epidemiological evidence for the \u2018antioxidant hypothesis\u2019","volume":"7","author":"Stanner SA","year":"2003","journal-title":"Public Health Nutr"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.12.1139"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.04.032"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665109991753"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03413.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101043440106"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101113440206"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.11.001"},{"key":"e_1_2_9_11_1","first-page":"17","article-title":"Serum levels of antioxidant vitamins (alpha tocopherol, beta carotene, and ascorbic acid) in children with bronchial asthma","volume":"42","author":"Kalayci O","year":"2000","journal-title":"Turk J Pediatr"},{"key":"e_1_2_9_12_1","first-page":"213","article-title":"Evaluation of the serum antioxidant status in asthmatic children","volume":"45","author":"Liao MF","year":"2004","journal-title":"Acta Paediatr Taiwan"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.01014.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2009.148"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh053"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200301-055OC"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01009.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2005.165"},{"key":"e_1_2_9_19_1","first-page":"174","volume-title":"Nutritional Epidemiology","author":"Hunter D","year":"1998"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg181"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200512-1946OC"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/84.4.903"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-220OC"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02267.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2011.67"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00117803"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0098-2997(03)00028-1"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.12307","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.12307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T21:30:48Z","timestamp":1694467848000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.12307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,11]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/all.12307"],"URL":"https:\/\/doi.org\/10.1111\/all.12307","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,11]]}}}