{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:52:00Z","timestamp":1782489120566,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T00:00:00Z","timestamp":1387756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Nonsteroidal anti\u2010inflammatory drugs (NSAIDs) are the most frequent medicaments involved in drug hypersensitivity reactions, with NSAID<\/jats:styled-content>\u2010induced urticaria\/angioedema (NIUA<\/jats:styled-content>) being the most frequent clinical entity. The natural evolution of NIUA<\/jats:styled-content> has been suggested to lead to chronic urticaria (CU<\/jats:styled-content>) in an important proportion of patients, such that NIUA<\/jats:styled-content> may therefore precede CU<\/jats:styled-content>. Our aim was to verify whether these entities are related by following up a large cohort of patients with NIUA<\/jats:styled-content> as well as a control group over a long period of time.<\/jats:p><\/jats:sec>Methods<\/jats:title>The study comprised three groups: (i) patients with a confirmed history of NIUA<\/jats:styled-content> (more than two episodes with at least two different NSAID<\/jats:styled-content>s or positive drug provocation tests), (ii) patients with more than two episodes of urticaria\/angioedema to a single NSAID<\/jats:styled-content> with good tolerance to a strong COX<\/jats:styled-content>\u20101 inhibitor and\/or evidence by in vivo<\/jats:italic> tests supporting specific IgE antibodies to the drug (single NSAID\u2010induced urticaria\/angioedema, SNIUA<\/jats:styled-content>), and (iii) controls who tolerated NSAID<\/jats:styled-content>s. All cases in the three groups were followed up over a period of 12\u00a0years.<\/jats:p><\/jats:sec>Results<\/jats:title>There were 190 patients with NIUA<\/jats:styled-content> (64.6% female; mean age 43.71\u00a0\u00b1\u00a015.82\u00a0years, 110 with SNIUA<\/jats:styled-content>, and 152 controls. At the 12\u2010year evaluation, 12 patients with NIUA<\/jats:styled-content> (6.15%) had developed CU<\/jats:styled-content> over a 1\u2010 to 8\u2010year period. Similar proportions were seen in SNIUA<\/jats:styled-content> and controls.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Nonsteroidal anti\u2010inflammatory drugs\u2010induced urticaria\/angioedema does not seem to precede the onset of CU<\/jats:styled-content> over the medium term. Further research including a longer follow\u2010up is necessary to verify this observation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12335","type":"journal-article","created":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T09:06:48Z","timestamp":1387789608000},"page":"438-444","source":"Crossref","is-referenced-by-count":41,"title":["NSAID<\/scp>\u2010induced urticaria\/angioedema does not evolve into chronic urticaria: a 12\u2010year follow\u2010up study"],"prefix":"10.1111","volume":"69","author":[{"given":"I.","family":"Do\u00f1a","sequence":"first","affiliation":[{"name":"Allergy Service Carlos Haya Hospital Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Blanca\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Allergy Service Infanta Leonor Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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