{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:22:26Z","timestamp":1791400946234,"version":"4.3.3"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T00:00:00Z","timestamp":1387756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Eczematous skin lesions of atopic dermatitis (\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      ) as well as allergic and irritant contact dermatitis (ACD,\n                      <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\n                      ) are characterized by the same typical clinical signs, although due to different causes. In both\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">ACD<\/jats:styled-content>\n                      , the presence of T helper 17 cells which play an important role in host defense, has been reported. Furthermore, IL\u201017 is involved in tissue repair and remodeling. This study aimed to investigate IL\u201017 expression in acute eczematous skin lesions and correlate it with markers of remodeling in\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">ACD<\/jats:styled-content>\n                      , and\n                      <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Skin specimens were taken from positive patch test reactions to aeroallergens, contact allergens, and irritants at days 2, 3, and 4. Inflammatory cells as well as the expression of cytokines and extracellular matrix proteins were evaluated by immunofluorescence staining and confocal microscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Allergic contact dermatitis and\n                      <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\n                      were characterized by IFN\u2010\u03b3 expression, whereas in AD lesions, IL\u201013 expression and high numbers of eosinophils were the prominent phenotype. Expression of IL\u201017, but also IL\u201021 and IL\u201022, was observed in all eczema subtypes. The number of IL\u201022+ T cells correlated with the number of eosinophils. Markers of remodeling such as MMP\u20109, procollagen\u20103, and tenascin C were observed in all acute eczematous lesions, while a correlation of IL\u201017+ T cell numbers with tenascin C\u2010expressing cells and MMP\u20109+ eosinophils was apparent.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The expression of IL\u201017 and related cytokines, such as IL\u201022, was demonstrated in acute eczematous lesions independent of their pathogenesis. Our results suggest a potential role for IL\u201017 in remodeling of the skin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.12351","type":"journal-article","created":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T04:36:42Z","timestamp":1387773402000},"page":"125-131","source":"Crossref","is-referenced-by-count":64,"title":["Th17 cells and tissue remodeling in atopic and contact dermatitis"],"prefix":"10.1111","volume":"69","author":[{"given":"D.","family":"Simon","sequence":"first","affiliation":[{"name":"Department of Dermatology Inselspital Bern University Hospital Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Aeberhard","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Erdemoglu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Inselspital Bern 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