{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:13:54Z","timestamp":1791213234532,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T00:00:00Z","timestamp":1390867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Abstract<\/jats:title>Mutations in FLG<\/jats:styled-content><\/jats:italic> coding profilaggrin cause ichthyosis vulgaris and are an important predisposing factor for atopic dermatitis. Until now, most case\u2013control studies and population\u2010based screenings have been performed only for prevalent mutations. In this study, we established a high\u2010throughput FLG<\/jats:styled-content><\/jats:italic> mutation detection system by real\u2010time PCR<\/jats:styled-content> with a set of two double\u2010dye probes and conducted comprehensive screening for almost all of the Japanese\u2010population\u2010specific FLG<\/jats:styled-content><\/jats:italic> mutations (ten FLG<\/jats:styled-content><\/jats:italic> mutations). The present comprehensive screening for all ten FLG<\/jats:styled-content><\/jats:italic> mutations provided a more precise prevalence rate for FLG<\/jats:styled-content><\/jats:italic> mutations (11.1%, n<\/jats:italic>\u00a0=\u00a0820), which seemed high compared with data of previous reports based on screening for limited numbers of FLG<\/jats:styled-content><\/jats:italic> mutations. Our comprehensive screening suggested that population\u2010specific FLG<\/jats:styled-content><\/jats:italic> mutations may be a significant predisposing factor for hay fever (odds ratio\u00a0=\u00a02.01 [95% CI<\/jats:styled-content>: 1.027\u20133.936, P<\/jats:italic>\u00a0<\u00a00.05]), although the sample sizes of this study were too small for reliable subphenotype analysis on the association between FLG<\/jats:styled-content><\/jats:italic> mutations and hay fever in the eczema patients and the noneczema individuals, and it is not clear whether the association between FLG<\/jats:styled-content><\/jats:italic> mutations and hay fever is due to the close association between FLG<\/jats:styled-content><\/jats:italic> mutations and hay fever patients with eczema.<\/jats:p>","DOI":"10.1111\/all.12369","type":"journal-article","created":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T08:19:32Z","timestamp":1390897172000},"page":"537-540","source":"Crossref","is-referenced-by-count":54,"title":["Comprehensive screening for a complete set of Japanese\u2010population\u2010specific filaggrin gene mutations"],"prefix":"10.1111","volume":"69","author":[{"given":"M.","family":"Kono","sequence":"first","affiliation":[{"name":"Department of Dermatology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Ohguchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Tsujiuchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Hamajima","sequence":"additional","affiliation":[{"name":"Department of Healthcare Administration Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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