{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:28:57Z","timestamp":1790684937327,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T00:00:00Z","timestamp":1395878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There are studies demonstrating that skin\u2010test sensitivity to penicillins can decrease over time and that allergic patients may lose sensitivity if the responsible compounds are avoided. With regard to subjects with <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>gE\u2010mediated hypersensitivity to cephalosporins, however, such studies are lacking. We evaluated prospectively in a 5\u2010year follow\u2010up 72 cephalosporin\u2010allergic patients. After the first evaluation, patients were classified into two groups according to their patterns of allergologic\u2010test positivity: to both penicillins and cephalosporins (group A), or only to cephalosporins (group B). Skin tests and serum\u2010specific IgE assays were repeated 1\u00a0year later and, in case of persistent positivity, 3 and 5\u00a0years after the first allergologic examination. Seven (43.7%) of the 16 subjects of group A and 38 (67.8%) of the 56 patients of group B became negative; one was lost to follow\u2010up. Patients of group B became negative sooner and more frequently than group A subjects.<\/jats:p>","DOI":"10.1111\/all.12390","type":"journal-article","created":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T16:57:17Z","timestamp":1395939437000},"page":"806-809","source":"Crossref","is-referenced-by-count":90,"title":["Natural evolution of skin\u2010test sensitivity in patients with IgE\u2010mediated hypersensitivity to cephalosporins"],"prefix":"10.1111","volume":"69","author":[{"given":"A.","family":"Romano","sequence":"first","affiliation":[{"name":"Allergy Unit Complesso Integrato Columbus Rome Italy"},{"name":"IRCCS Oasi Maria S.S. Troina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Gaeta","sequence":"additional","affiliation":[{"name":"Allergy Unit Complesso Integrato Columbus Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. L.","family":"Valluzzi","sequence":"additional","affiliation":[{"name":"Allergy Unit Complesso Integrato Columbus Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Zaffiro","sequence":"additional","affiliation":[{"name":"Ambulatorio di Allergologia IDI\u2010IRCCS Capranica Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Caruso","sequence":"additional","affiliation":[{"name":"Allergy Unit Complesso Integrato Columbus Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Quaratino","sequence":"additional","affiliation":[{"name":"Ambulatorio di Allergologia IDI\u2010IRCCS Capranica Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.57.s72.18.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02317.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.10.032"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3178"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.06.052"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03846.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00280.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01924.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(81)90180-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70197-1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.55.11.857"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92975-3"},{"key":"e_1_2_7_14_1","first-page":"162","article-title":"Positive allergological tests may turn negative with no further exposure to the specific allergen: a long\u2010term, prospective, follow\u2010up study in patients allergic to penicillin","volume":"6","author":"Patriarca G","year":"1996","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70439-2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01713.x"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.12390","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.12390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:34:41Z","timestamp":1695573281000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.12390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,27]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/all.12390"],"URL":"https:\/\/doi.org\/10.1111\/all.12390","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,27]]}}}