{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:44:59Z","timestamp":1775306699271,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T00:00:00Z","timestamp":1395878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In steroid\u2010naive patients with asthma, several gene variants are associated with a short\u2010term response to inhaled corticosteroid (<jats:styled-content style=\"fixed-case\">ICS<\/jats:styled-content>) treatment; this has mostly been observed in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>aucasians. However, not many studies have been conducted for other ethnicities. Here, we aimed to determine the relationship between the annual decline in forced expiratory flow volume in one second (<jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content><jats:sub>1<\/jats:sub>) and the variant of the glucocorticoid\u2010induced transcript 1 gene (<jats:italic><jats:styled-content style=\"fixed-case\">GLCCI<\/jats:styled-content>1<\/jats:italic>) in Japanese patients with asthma receiving long\u2010term <jats:styled-content style=\"fixed-case\">ICS<\/jats:styled-content> treatment, taking into account the effect of high serum periostin levels, a known association factor of pulmonary function decline and a marker of refractory eosinophilic\/<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h2 inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, 224 patients with asthma receiving <jats:styled-content style=\"fixed-case\">ICS<\/jats:styled-content> treatment for at least 4\u00a0years were enrolled. The effects of single\u2010nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) in <jats:italic><jats:styled-content style=\"fixed-case\">GLCCI<\/jats:styled-content>1,<\/jats:italic> stress\u2010induced phosphoprotein 1 (<jats:italic><jats:styled-content style=\"fixed-case\">STIP<\/jats:styled-content>1<\/jats:italic>), and <jats:styled-content style=\"fixed-case\"><jats:italic>T<\/jats:italic><\/jats:styled-content> <jats:italic>gene<\/jats:italic> on the decline in <jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content><jats:sub>1<\/jats:sub> of 30\u00a0ml\/year or greater were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Besides the known contributing factors, that is, the most intensive treatment step, ex\u2010smoking, and high serum periostin levels (\u226595\u00a0ng\/ml), the <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> genotype of <jats:italic><jats:styled-content style=\"fixed-case\">GLCC<\/jats:styled-content>I1<\/jats:italic> rs37973, and not other <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s, was independently associated with a decline in <jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content><jats:sub>1<\/jats:sub> of 30\u00a0ml\/year or greater. When patients were stratified according to their serum periostin levels, the <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> genotype of rs37973 was significantly associated with blood eosinophilia (\u2265250\/\u03bcl) in the high serum periostin group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A <jats:italic><jats:styled-content style=\"fixed-case\">GLCCI<\/jats:styled-content>1<\/jats:italic> variant is a risk factor of pulmonary function decline in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese patients with asthma receiving long\u2010term <jats:styled-content style=\"fixed-case\">ICS<\/jats:styled-content> treatment. Thus, <jats:italic><jats:styled-content style=\"fixed-case\">GLCCI<\/jats:styled-content>1<\/jats:italic> may be associated with response to <jats:styled-content style=\"fixed-case\">ICS<\/jats:styled-content> across ethnicities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12400","type":"journal-article","created":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T13:40:52Z","timestamp":1395927652000},"page":"668-673","source":"Crossref","is-referenced-by-count":39,"title":["<i><scp>GLCCI<\/scp>1<\/i> variant accelerates pulmonary function decline in patients with asthma receiving inhaled corticosteroids"],"prefix":"10.1111","volume":"69","author":[{"given":"Y.","family":"Izuhara","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Graduate School of Medicine Kyoto University Kyoto Japan"},{"name":"Kinki Hokuriku Airway Disease Conference (KiHAC) Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Kanemitsu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Graduate School of Medicine Kyoto University Kyoto Japan"},{"name":"Kinki Hokuriku Airway Disease Conference (KiHAC) Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Izuhara","sequence":"additional","affiliation":[{"name":"Division of Medical Biochemistry Department of Biomolecular Sciences Saga Medical School Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Tohda","sequence":"additional","affiliation":[{"name":"Kinki Hokuriku Airway Disease Conference (KiHAC) Osaka Japan"},{"name":"Department of Respiratory Medicine and Allergology Faculty of Medicine Kinki University Osaka 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Ohnishi","sequence":"additional","affiliation":[{"name":"Kinki Hokuriku Airway Disease Conference (KiHAC) Osaka Japan"},{"name":"Department of Hematology and Respiratory Medicine Kochi University Kochi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Nakano","sequence":"additional","affiliation":[{"name":"Kinki Hokuriku Airway Disease Conference (KiHAC) Osaka Japan"},{"name":"Division of Respiratory Medicine Department of Internal Medicine Shiga University of Medical Science Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Oguma","sequence":"additional","affiliation":[{"name":"Kinki Hokuriku Airway Disease Conference (KiHAC) Osaka Japan"},{"name":"Division of Respiratory Medicine Department of Internal Medicine Shiga University of Medical Science Shiga 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