{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:21:57Z","timestamp":1791397317143,"version":"4.3.3"},"reference-count":56,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,4,29]],"date-time":"2014-04-29T00:00:00Z","timestamp":1398729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Food allergens have been evidenced in breast milk under physiological conditions, but the kinetic and the role of this passage in food allergies are still unclear. We then aimed to analyze the passage of peanut allergens in human breast milk and their allergenicity\/immunomodulatory properties.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Human breast milk was collected from two non\u2010atopic peanut\u2010tolerant mothers before and at different time points after ingestion of 30\u00a0g of commercial roasted peanut. Ara h 6, Ara h 6 immune complexes, and the IgE binding capacity of breast milk samples were measured using specific immunoassays. Their allergenic functionality was then assessed using cell\u2010based assay. Finally, human breast milk obtained before or after peanut ingestion was administered intragastrically to <jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\/c mice at different ages, and mice were further experimentally sensitized to peanut using cholera toxin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ara h 6 is detected as soon as 10\u00a0min after peanut ingestion, with peak values observed within the first hour after ingestion. The transfer is long\u2010lasting, small quantities of peanut allergens being detected over a 24\u2010h period. IgG\u2013Ara h 6 and IgA\u2013Ara h 6 immune complexes are evidenced, following a different kinetic of excretion than free allergens. Peanut allergens transferred in milk are IgE reactive and can induce an allergic reaction <jats:italic>in vitro<\/jats:italic>. However, administration of human breast milk to young mice, notably before weaning, does not lead to sensitization, but instead to partial oral tolerance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The low quantities of immunologically active allergens transferred through breast milk may prevent instead of priming allergic sensitization to peanut.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12411","type":"journal-article","created":{"date-parts":[[2014,4,29]],"date-time":"2014-04-29T05:52:50Z","timestamp":1398750770000},"page":"888-897","source":"Crossref","is-referenced-by-count":93,"title":["Peanut allergens are rapidly transferred in human breast milk and can prevent sensitization in mice"],"prefix":"10.1111","volume":"69","author":[{"given":"H.","family":"Bernard","sequence":"first","affiliation":[{"name":"INRA UR496 Unit\u00e9 d'Immuno\u2010Allergie Alimentaire Jouy\u2010en\u2010Josas France"},{"name":"CEA IBiTecS Service de Pharmacologie et 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