{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:03:57Z","timestamp":1790471037792,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T00:00:00Z","timestamp":1401926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Increased serum IgE levels are characteristic but not specific for allergic diseases. Particularly, severe atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) overlaps with hyper\u2010IgE syndromes (<jats:styled-content style=\"fixed-case\">HIES<\/jats:styled-content>) regarding eczema, eosinophilia, and increased serum IgE levels. <jats:styled-content style=\"fixed-case\">HIES<\/jats:styled-content> are primary immunodeficiencies due to monogenetic defects such as in the genes <jats:italic><jats:styled-content style=\"fixed-case\">DOCK<\/jats:styled-content>8<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>3<\/jats:italic>. As it is not known to date why allergic manifestations are not present in all <jats:styled-content style=\"fixed-case\">HIES<\/jats:styled-content> entities, we assessed the specificity of serum IgE of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HIES<\/jats:styled-content> patients in the context of clinical and immunological findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data, skin prick tests, specific IgE to aero\u2010 and food allergens, and T helper (Th) subpopulations were compared in <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and molecularly defined <jats:styled-content style=\"fixed-case\">HIES<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total serum IgE levels were similarly increased in STAT3\u2010HIES, DOCK8\u2010HIES, and AD patients. The ratio of aeroallergen\u2010specific IgE to total IgE was highest in AD, whereas DOCK8\u2010HIES patients showed the highest specific serum IgE against food allergens. Overall, clinical allergy and skin prick test results complied with the specific IgE results. Th2\u2010cell numbers were significantly increased in DOCK8\u2010HIES and AD patients compared to STAT3\u2010<jats:styled-content style=\"fixed-case\">HIES<\/jats:styled-content> patients and controls. AD patients showed significantly higher <jats:styled-content style=\"fixed-case\">nT<\/jats:styled-content>reg\u2010cell counts compared to <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>3\u2010HIES and control individuals. High Th17\u2010cell counts were associated with asthma. Specific IgE values, skin prick test, and T\u2010cell subsets of STAT3\u2010HIES patients were comparable with those of healthy individuals except decreased Th17\u2010cell counts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hyper\u2010IgE syndromes and atopic dermatitis patients showed different sensitization pattern of serum IgE corresponding to the allergic disease manifestations and Th\u2010cell subset data, suggesting a key role of <jats:styled-content style=\"fixed-case\">DOCK<\/jats:styled-content>8 in the development of food allergy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12416","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T07:02:11Z","timestamp":1401951731000},"page":"943-953","source":"Crossref","is-referenced-by-count":96,"title":["Atopic dermatitis, <scp>STAT<\/scp>3\u2010 and <scp>DOCK<\/scp>8\u2010hyper\u2010IgE syndromes differ in IgE\u2010based sensitization pattern"],"prefix":"10.1111","volume":"69","author":[{"given":"A. C.","family":"Boos","sequence":"first","affiliation":[{"name":"University Children's Hospital at Dr. von Haunersches Kinderspital Ludwig Maximilian University Munich Germany"},{"name":"Dermatology and Allergy Ludwig Maximilian University Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Hagl","sequence":"additional","affiliation":[{"name":"University Children's Hospital at Dr. von Haunersches Kinderspital Ludwig Maximilian University Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Schlesinger","sequence":"additional","affiliation":[{"name":"University Children's Hospital at Dr. von Haunersches Kinderspital Ludwig Maximilian University Munich Germany"},{"name":"Dermatology and Allergy Ludwig Maximilian University Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. E.","family":"Halm","sequence":"additional","affiliation":[{"name":"University Children's Hospital at Dr. von Haunersches Kinderspital Ludwig Maximilian University Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Ballenberger","sequence":"additional","affiliation":[{"name":"University Children's Hospital at Dr. von Haunersches Kinderspital Ludwig Maximilian University Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Pinarci","sequence":"additional","affiliation":[{"name":"Dermatology and Allergy Ludwig Maximilian University Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Heinz","sequence":"additional","affiliation":[{"name":"University Children's Hospital at Dr. von Haunersches Kinderspital Ludwig Maximilian University Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Kreilinger","sequence":"additional","affiliation":[{"name":"University Children's Hospital at Dr. von Haunersches Kinderspital Ludwig Maximilian University Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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