{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T08:44:28Z","timestamp":1778575468217,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T00:00:00Z","timestamp":1399593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Skin testing\u2010guided elimination diet has proved unsuccessful for adult eosinophilic oesophagitis (<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>), whereas empiric six\u2010food elimination diet (<jats:styled-content style=\"fixed-case\">SFED<\/jats:styled-content>) achieves an efficacy of 70%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the efficacy of food\u2010specific serum <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\u2010targeted elimination diet (<jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">SFED<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective study in adult patients with <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>. Food\u2010specific serum <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>, skin prick test (<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>) and atopy patch test (<jats:styled-content style=\"fixed-case\">APT<\/jats:styled-content>) to foods included in <jats:styled-content style=\"fixed-case\">SFED<\/jats:styled-content> were performed. Those with \u22651 positive IgE test, defined by \u22650.1\u00a0kU\/l, followed a 6\u2010week <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>, whereas non\u2010IgE\u2010sensitized patients underwent a 6\u2010week SFED. Responders to diet (&lt;15\u00a0eos\/HPF) underwent individual reintroduction of foods followed by histological assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010three EoE patients were included (26 <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> and 17 <jats:styled-content style=\"fixed-case\">SFED<\/jats:styled-content>). Regarding <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>, the mean number of eliminated foods per patient was significantly lower than in SFED (3.81 <jats:italic>vs<\/jats:italic> 6; <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0&lt;\u00a00.001), being wheat (85%), nuts (73%) and cow's milk (61%) the most commonly foods withdrawn. No difference in histological response was observed between <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SFED<\/jats:styled-content> (73% <jats:italic>vs<\/jats:italic> 53%, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.17). Causative foods identified by food challenge were cow's milk (64%), wheat (28%), egg (21%) and legumes (7%), with a single food trigger in 71% of patients. <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> exhibited the higher accuracy to predict offending foods in IgE\u2010sensitized patients (sensitivity 87.5%, specificity 68% (<jats:italic>\u03ba<\/jats:italic>\u00a0=\u00a00.43)), with <jats:italic>k<\/jats:italic> values of 1 for cow's milk. APT results were all negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Histological remission was accomplished in 73% of patients undergoing <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>\u2010ED, which was nonsignificantly superior to <jats:styled-content style=\"fixed-case\">SFED<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> effectively identified cow's milk as a food trigger in IgE\u2010sensitized patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12420","type":"journal-article","created":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T12:44:36Z","timestamp":1399639476000},"page":"936-942","source":"Crossref","is-referenced-by-count":65,"title":["Efficacy of <scp>I<\/scp>g<scp>E<\/scp>\u2010targeted <i>vs<\/i> empiric six\u2010food elimination diets for adult eosinophilic 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