{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:11:21Z","timestamp":1790154681641,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T00:00:00Z","timestamp":1406678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nine cases of diclofenac hypersensitivity recorded by the Allergy Vigilance Network in France from 2002 to 2012 were studied. Data from history, symptoms, skin tests, basophil activation tests, and oral challenge (<jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>) were recorded. Grade 3 severe anaphylactic reactions occurred in seven cases of nine. IgE\u2010dependent anaphylaxis was confirmed in six cases: positive intradermal tests (<jats:italic>n<\/jats:italic>\u00a0=\u00a04), a syndromic reaction during skin tests (<jats:italic>n<\/jats:italic>\u00a0=\u00a01), and one case with grade 1 reaction and negative skin tests had an anaphylactic shock to the<jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>. A nonimmune reaction was suspected in one case. An IgE\u2010dependent mechanism may be the predominant cause of adverse reactions to diclofenac. Allergy skin tests must be carried out sequentially at the recommended concentrations.<jats:styled-content style=\"fixed-case\">BAT<\/jats:styled-content>s may be helpful because they can support the diagnosis of anaphylaxis. Given the risks of a direct challenge to diclofenac,<jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>to aspirin should be performed first to exclude a nonimmunologic hypersensitivity to<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s. Tests for specific IgEs to most frequently used<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s such as diclofenac and ibuprofen are urgently needed.<\/jats:p>","DOI":"10.1111\/all.12458","type":"journal-article","created":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T18:54:01Z","timestamp":1402944841000},"page":"1420-1423","source":"Crossref","is-referenced-by-count":27,"title":["Anaphylaxis to diclofenac: nine cases reported to the Allergy Vigilance Network in France"],"prefix":"10.1111","volume":"69","author":[{"given":"J.","family":"Picaud","sequence":"first","affiliation":[{"name":"Allergy Department Emile Durkheim Hospital Epinal France"},{"name":"Allergy Vigilance Network Vandoeuvre les Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Beaudouin","sequence":"additional","affiliation":[{"name":"Allergy Department Emile Durkheim Hospital Epinal France"},{"name":"Allergy Vigilance Network Vandoeuvre les Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Renaudin","sequence":"additional","affiliation":[{"name":"Allergy Department Emile Durkheim Hospital Epinal France"},{"name":"Allergy Vigilance Network Vandoeuvre les Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Pirson","sequence":"additional","affiliation":[{"name":"Allergy Vigilance Network Vandoeuvre les Nancy France"},{"name":"Pneumology Department Saint\u2010Luc University Hospital Bruxelles Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Metz\u2010Favre","sequence":"additional","affiliation":[{"name":"Allergy Vigilance Network Vandoeuvre les Nancy France"},{"name":"Pneumology Department New Civil Hospital Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Dron\u2010Gonzalvez","sequence":"additional","affiliation":[{"name":"Allergy Vigilance Network Vandoeuvre les Nancy France"},{"name":"Allergy Vigilance Network Martigues France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A.","family":"Moneret\u2010Vautrin","sequence":"additional","affiliation":[{"name":"Allergy Department Emile Durkheim Hospital Epinal France"},{"name":"Allergy Vigilance Network Vandoeuvre les Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02557.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000337660"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12168"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02737644"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1046\/j.0105-4538.2001.00001.x-i8","article-title":"General considerations for skin test procedures in the diagnosis of drug hypersensitivity","volume":"57","author":"Brockow K","year":"2002","journal-title":"Allergy"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2004.12.027"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00785.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03014979"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200528060-00006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1A140"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2011.02601.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0379-0738(93)90098-U"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.02050.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00562.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013707"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00279.x"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.12458","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.12458","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T19:32:33Z","timestamp":1716838353000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.12458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,30]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/all.12458"],"URL":"https:\/\/doi.org\/10.1111\/all.12458","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,30]]}}}