{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:49:36Z","timestamp":1789386576633,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T00:00:00Z","timestamp":1407888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Perioperative allergic reactions to chlorhexidine are often severe and easily overlooked. Although rare, the prevalence remains unknown. Correct diagnosis is crucial, but no validated provocation model exists, and other diagnostic tests have never been evaluated. The aims were to estimate (i) the prevalence of chlorhexidine allergy in perioperative allergy and (ii) the specificity and sensitivity for diagnostic tests for chlorhexidine allergy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included all patients investigated for suspected perioperative allergic reactions in the Danish Anaesthesia Allergy Centre during 2004\u20132012. The following tests were performed: specific<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>mmunocap<jats:sup>\u00ae<\/jats:sup>;<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>hadia<jats:styled-content style=\"fixed-case\">AB<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>weden), histamine release test (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) (<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>efLab<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>p<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>enmark), skin prick test (<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>) and intradermal test (<jats:styled-content style=\"fixed-case\">IDT<\/jats:styled-content>). Positivity criteria were as follows: specific<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\u00a0&gt;0.35\u00a0k<jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>\/l;<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>class 1\u201312;<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>mean wheal diameter\u00a0\u22653\u00a0mm;<jats:styled-content style=\"fixed-case\">IDT<\/jats:styled-content>mean wheal diameter\u00a0\u2265\u00a0twice the diameter of negative control. Chlorhexidine allergy was<jats:italic>post hoc<\/jats:italic>defined as a relevant clinical reaction to chlorhexidine combined with two or more positive tests. Based on this definition, sensitivity and specificity were estimated for each test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 22 of 228 patients (9.6%) met the definition of allergy to chlorhexidine. Estimated sensitivity and specificity were as follows: specific<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>(sensitivity 100% and specificity 97%),<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>(sensitivity 55% and specificity 99%),<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>(sensitivity 95% and specificity 97%) and<jats:styled-content style=\"fixed-case\">IDT<\/jats:styled-content>(sensitivity 68% and specificity 100%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients investigated for suspected perioperative allergic reactions, 9.6% were diagnosed with allergy to chlorhexidine. Using our definition of chlorhexidine allergy, the highest combined estimated sensitivity and specificity was found for specific IgE and<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12466","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T13:56:43Z","timestamp":1403618203000},"page":"1390-1396","source":"Crossref","is-referenced-by-count":127,"title":["Standardized testing with chlorhexidine in perioperative allergy \u2013 a large single\u2010centre evaluation"],"prefix":"10.1111","volume":"69","author":[{"given":"M. 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