{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:34:39Z","timestamp":1791254079412,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,8,16]],"date-time":"2014-08-16T00:00:00Z","timestamp":1408147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["310030.130029"],"award-info":[{"award-number":["310030.130029"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Thymic stromal lymphopoietin (<jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content>) is a cytokine primarily produced by epithelial cells, which has been shown to be a potent inducer of T\u2010helper 2 (Th2)\u2010type responses. However, <jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content> has pleiotropic effects upon immune cells, and although extensively studied in the context of atopic asthma, its relevance as a therapeutic target and its role in the pathogenesis of nonatopic asthma remains unknown. We sought to investigate the role of <jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content> in atopic, nonatopic and viral\u2010induced exacerbations of pulmonary inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using stringently defined murine models of atopic, nonatopic and virally exacerbated forms of pulmonary inflammation, we compared inflammatory responses of C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 wild\u2010type (<jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content> receptor\u2010deficient (<jats:styled-content style=\"fixed-case\">TSLPR KO<\/jats:styled-content>) mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thymic stromal lymphopoietin receptor (<jats:styled-content style=\"fixed-case\">TSLPR<\/jats:styled-content>) signaling was crucial for the development of atopic asthma. Specifically, <jats:styled-content style=\"fixed-case\">TSLPR<\/jats:styled-content> signaling to lung recruited <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+ T cells enhanced eosinophilia, goblet cell hyperplasia, and overall inflammation within the airways. In contrast, the absence of <jats:styled-content style=\"fixed-case\">TSLPR<\/jats:styled-content> signaling was associated with strikingly exaggerated pulmonary neutrophilic inflammation in a nonatopic model of airway inflammation. The inflammation was associated with excessive levels of interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201017A in the lungs, indicating that <jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content> negatively regulates <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A. In addition, in a model of influenza\u2010induced exacerbation of atopic airway inflammation, the absence of <jats:styled-content style=\"fixed-case\">TSLPR<\/jats:styled-content> signaling also led to exaggerated neutrophilic inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Thymic stromal lymphopoietin plays divergent roles in the pathogenesis of atopic and nonatopic asthma phenotypes by either enhancing Th2 responses or curtailing T\u2010helper 17 responses. These findings raise important caveats for the design of therapeutic interventions targeting <jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content> in asthma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12469","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T21:27:06Z","timestamp":1403645226000},"page":"1333-1342","source":"Crossref","is-referenced-by-count":17,"title":["Thymic stromal lymphopoietin plays divergent roles in murine models of atopic and nonatopic airway inflammation"],"prefix":"10.1111","volume":"69","author":[{"given":"K.","family":"Yadava","sequence":"first","affiliation":[{"name":"Service de Pneumologie Faculty of Biology and Medicine University of Lausanne CHUV Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Massacand","sequence":"additional","affiliation":[{"name":"Global Health Institute EPFL Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Mosconi","sequence":"additional","affiliation":[{"name":"Global Health Institute EPFL Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. P.","family":"Nicod","sequence":"additional","affiliation":[{"name":"Service de Pneumologie Faculty of Biology and Medicine University of Lausanne CHUV Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. L.","family":"Harris","sequence":"additional","affiliation":[{"name":"Global Health Institute EPFL Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. J.","family":"Marsland","sequence":"additional","affiliation":[{"name":"Service de Pneumologie Faculty of Biology and Medicine University of Lausanne CHUV Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1852"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906367106"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081499"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801532105"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.9.6557"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.08.031"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.12.8183"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050199"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.03.019"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051135"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.1.336"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI33559"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.50"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.05.015"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2011.64"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.119411"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.3.268"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.5.424"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200808-087RM"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1892"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00202.2010"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031975"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.11.6720"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.182.3.1641"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20112691"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(95)70128-1"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.04.021"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002244"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-202404"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2013.12"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00391-6"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706942104"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061401"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2009.7"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000085432"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.8.4430"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.12469","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.12469","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T01:00:43Z","timestamp":1696467643000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.12469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,16]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/all.12469"],"URL":"https:\/\/doi.org\/10.1111\/all.12469","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,16]]}}}