{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:46:21Z","timestamp":1788993981679,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T00:00:00Z","timestamp":1407110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Stallergenes, S.A."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Grass and olive are the most frequently pollens that induce seasonal allergic rhinitis in Spain. Cross\u2010reactivity due to panallergens shared by them and overlapping pollination complicates the recognition of allergy\u2010causing agents, making it difficult to identify the most appropriate allergen immunotherapy (\n                      <jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content>\n                      ) to use. The aim of this study was to determine the sensitization pattern to major grass and olive pollen allergens using component\u2010resolved diagnostics in patients with seasonal allergic rhinitis (\n                      <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>\n                      ) and positive skin prick test to grass and olive pollens and evaluate how knowledge of the sensitization patterns might influence\n                      <jats:styled-content style=\"fixed-case\">AIT<\/jats:styled-content>\n                      prescription.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>After informed written consent, a total of 1263 patients were recruited. A serum determination of specific IgE levels to Ole e 1 and Phl p 1\u00a0+\u00a05 was performed to all patients. A comparison was made before and after obtaining the specific IgE results, and differences in diagnosis were stated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At the 0.35\u00a0kU\/l cut\u2010off point, 71.2% of patients were positive to Ole e 1 and Phl p 1\u00a0+\u00a05, 14% were positive only to Phl p 1\u00a0+\u00a05 and 12% were positive only to Ole e 1. Based on available clinical data and skin prick test results, 922 (73%) patients would have been indicated for a mixture of grass and olive pollens for AIT. In 56.8% of patients, there was non\u2010coincidence in the composition of AIT that would be selected before and after investigators received the\n                      <jats:italic>in vitro<\/jats:italic>\n                      data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The diagnostic accuracy of the recombinant allergen\u2010specific IgE test could help to improve the selection of specific\u2010allergen immunotherapy in polysensitized patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.12474","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T09:42:27Z","timestamp":1404294147000},"page":"1357-1363","source":"Crossref","is-referenced-by-count":49,"title":["Olive, grass or both? Molecular diagnosis for the allergen immunotherapy selection in polysensitized pollinic patients"],"prefix":"10.1111","volume":"69","author":[{"given":"C.","family":"Moreno","sequence":"first","affiliation":[{"name":"Hospital Universitario Reina Sof\u00eda Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Justicia","sequence":"additional","affiliation":[{"name":"Stallergenes Ib\u00e9rica Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Quiralte","sequence":"additional","affiliation":[{"name":"Hospital Virgen del Roc\u00edo Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1.","family":"Moreno\u2010Ancillo","sequence":"additional","affiliation":[{"name":"Hospital Nuestra Se\u00f1ora del Prado Talavera de la Reina Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Iglesias\u2010Cadarso","sequence":"additional","affiliation":[{"name":"Hospital Puerta de Hierro Majadahonda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Torrecillas","sequence":"additional","affiliation":[{"name":"Complejo Universitario Hospitalario de Albacete Albacete Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Labarta","sequence":"additional","affiliation":[{"name":"Policl\u00ednica Alto Arag\u00f3n Hospital San Jorge Huesca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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Superficie de olivar de las CCAA y provincias. Anuario de estad\u00edstica agroalimentaria y pesquera 2007. [cited]; Available from:http:\/\/www.mapa.es\/es\/estadistica\/pags\/anuario\/2007\/indice.asp?parte=2&capitulo=17."},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.04.006"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01581.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.01955.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.09.034"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00526.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.11.019"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00138707"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.12474","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.12474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T20:59:46Z","timestamp":1696453186000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.12474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,4]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/all.12474"],"URL":"https:\/\/doi.org\/10.1111\/all.12474","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,4]]}}}