{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T20:40:06Z","timestamp":1768250406783,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T00:00:00Z","timestamp":1408665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Egg\u2010sensitized infants who have never eaten egg may react at first ingestion. We sought to determine the association between skin prick test (SPT) and specific IgE (<jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>) to egg proteins (EP) and oral food challenge (OFC) outcomes to find cut\u2010off points which can diagnose egg allergy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and fifty\u2010four infants up to 18\u00a0months, with cow's milk allergy (CMA) and\/or atopic dermatitis (AD) without previous egg consumption, were recruited. SPT to EP were performed. If it was positive, <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> was performed. If positive SPT and\/or <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>94), OFC was performed between 12 and 18\u00a0months. Receiver operating characteristic (ROC) curves were plotted, and the outcome of the OFC was related to SPT and <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>. The cut\u2010off points with the best diagnostic accuracy were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010four patients were sensitized to egg (69%) and 60 nonsensitized (31%). Of the sensitized, 27 tolerated cooked (CE) and raw egg (RE) (28.7%). Sixty\u2010seven were allergic (71.3%): 29 reacted to CE, seven to egg yolk (EY) and 22 to egg white (EW) and 38 reacted to RE. 69.2% tolerated CE. EW SPT and ovalbumin (OVA) <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> have the best area under the curve (AUC). The higher positive predictive values (PPV) were obtained for EW SPT and EW <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In egg\u2010sensitized infants with EW SPT \u22658\u00a0mm and\/or EW <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> \u22658.36\u00a0KU\/l, egg diagnostic OFC can be avoided as there is 94% probability of becoming positive. In the other patients, OFC should be performed safely and early to avoid unnecessary diets.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12483","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T15:27:28Z","timestamp":1405006048000},"page":"1350-1356","source":"Crossref","is-referenced-by-count":23,"title":["Tolerance to egg proteins in egg\u2010sensitized infants without previous consumption"],"prefix":"10.1111","volume":"69","author":[{"given":"M.","family":"\u00c1lvaro","sequence":"first","affiliation":[{"name":"Allergy and Clinical Immunology Department Hospital Sant Joan de D\u00e9u Universitat de Barcelona Esplugues Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00aa. B.","family":"Garc\u00eda\u2010Paba","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Department Hospital Sant Joan de D\u00e9u Universitat de Barcelona Esplugues Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00aa. T.","family":"Giner","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Department Hospital Sant Joan de D\u00e9u Universitat de Barcelona Esplugues Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Piquer","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Department Hospital Sant Joan de D\u00e9u Universitat de Barcelona Esplugues Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Department Hospital Sant Joan de D\u00e9u Universitat de Barcelona Esplugues Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Lozano","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Department Hospital Sant Joan de D\u00e9u Universitat de Barcelona Esplugues Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Department Hospital Sant Joan de D\u00e9u Universitat de Barcelona Esplugues Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Machinena","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Department Hospital Sant Joan de D\u00e9u Universitat de Barcelona Esplugues Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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