{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:14:03Z","timestamp":1791274443717,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,24]],"date-time":"2014-12-24T00:00:00Z","timestamp":1419379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G0801056\/1"],"award-info":[{"award-number":["G0801056\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A number of genetic variants have been associated with allergic sensitization, but whether these are allergen specific or increase susceptibility to poly\u2010sensitization is unknown. Using data from the large multicentre population\u2010based European Community Respiratory Health Survey, we assessed the association between 10 loci and specific IgE and skin prick tests to individual allergens and poly\u2010sensitization. We found that the 10 loci associate with sensitization to different allergens in a nonspecific manner and that one in particular, <jats:italic>C11orf30<\/jats:italic>\u2010rs2155219, doubles the risk of poly\u2010sensitization (specific IgE\/4 allergens: <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.81, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.80\u20134.24; skin prick test\/4+ allergens: <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.27, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.34\u20133.95). The association of rs2155219 with higher levels of expression of <jats:italic>C11orf30<\/jats:italic>, which may be involved in transcription repression of interferon\u2010stimulated genes, and its association with sensitization to multiple allergens suggest that this locus is highly relevant for atopy.<\/jats:p>","DOI":"10.1111\/all.12557","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T11:34:01Z","timestamp":1418124841000},"page":"328-333","source":"Crossref","is-referenced-by-count":27,"title":["The locus <i>C11orf30<\/i> increases susceptibility to poly\u2010sensitization"],"prefix":"10.1111","volume":"70","author":[{"given":"A. F. S.","family":"Amaral","sequence":"first","affiliation":[{"name":"Respiratory Epidemiology Occupational Medicine and Public Health National Heart and Lung Institute Imperial College London UK"},{"name":"MRC\u2010PHE Centre for Environment &amp; Health London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Minelli","sequence":"additional","affiliation":[{"name":"Respiratory Epidemiology Occupational Medicine and Public Health National Heart and Lung Institute Imperial College London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Guerra","sequence":"additional","affiliation":[{"name":"Centre for Research in Environmental Epidemiology (CREAL) Universitat Pompeu Fabra CIBERESP Barcelona Spain"},{"name":"Arizona Respiratory Center University of Arizona Tucson AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wjst","sequence":"additional","affiliation":[{"name":"Molecular Genetics of Lung Diseases Comprehensive Pneumology Center Helmholtz Zentrum M\u00fcnchen German Research Center for Environmental Health Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Probst\u2010Hensch","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute Basel Switzerland"},{"name":"University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Pin","sequence":"additional","affiliation":[{"name":"P\u00e9diatrie CHU de Grenoble Institut Albert Bonniot INSERM Grenoble France"},{"name":"Universit\u00e9 Joseph Fourier Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Svanes","sequence":"additional","affiliation":[{"name":"Bergen Respiratory Research Group Institute of Medicine University of Bergen Bergen Norway"},{"name":"Department of Occupational Medicine Haukeland University Hospital Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Janson","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences: Respiratory, Allergy and Sleep Research Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Heinrich","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology I Helmholtz Zentrum Munich Germany"},{"name":"Institute and Outpatient Clinic for Occupational Social and Environmental Medicine Inner City Clinic University Hospital Munich Ludwig Maximilian University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. L.","family":"Jarvis","sequence":"additional","affiliation":[{"name":"Respiratory Epidemiology Occupational Medicine and Public Health National Heart and Lung Institute Imperial College London UK"},{"name":"MRC\u2010PHE Centre for Environment &amp; Health London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.12.037"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.08.030"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.09.040"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2694"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00046802"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.53.8.662"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02046.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906312"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01581.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115029109"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1210-1248"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.347"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60874-X"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.175"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.12557","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.12557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T01:05:21Z","timestamp":1696467921000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.12557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,24]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/all.12557"],"URL":"https:\/\/doi.org\/10.1111\/all.12557","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,24]]}}}