{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:11:11Z","timestamp":1791173471579,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T00:00:00Z","timestamp":1421193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with asthma may be more susceptible to adverse events (<jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>s) with sublingual immunotherapy tablet (<jats:styled-content style=\"fixed-case\">SLIT<\/jats:styled-content>\u2010tablet) treatment, such as severe systemic reactions and asthma\u2010related events. Using data from eight trials of grass SLIT\u2010tablet in subjects with allergic rhinitis with\/without conjunctivitis (<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>\/C), <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content> frequencies were determined in adults and children with and without reported asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from randomized, double\u2010blind, placebo\u2010controlled trials of Timothy grass SLIT\u2010tablet <jats:styled-content style=\"fixed-case\">MK<\/jats:styled-content>\u20107243 (2800 <jats:styled-content style=\"fixed-case\">BAU<\/jats:styled-content>\/75\u00a0000 <jats:styled-content style=\"fixed-case\">SQ<\/jats:styled-content>\u2010T, Merck\/<jats:styled-content style=\"fixed-case\">ALK<\/jats:styled-content>\u2010Abell\u00f3) were pooled for <jats:italic>post hoc<\/jats:italic> analyses. Subjects with uncontrolled and severe asthma were excluded from the trials. Frequencies for treatment\u2010emergent <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>s (<jats:styled-content style=\"fixed-case\">TEAE<\/jats:styled-content>s), local allergic swelling (mouth or throat), systemic allergic reactions, and asthma\u2010related treatment\u2010related <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>s (<jats:styled-content style=\"fixed-case\">TRAE<\/jats:styled-content>s) were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among adults (<jats:italic>n<\/jats:italic>\u00a0=\u00a03314) and children (<jats:italic>n<\/jats:italic>\u00a0=\u00a0881), 24% and 31%, respectively, had reported asthma. No serious local allergic swellings or serious systemic allergic reactions occurred in subjects with asthma treated with SLIT\u2010tablet. There was no evidence of increased <jats:styled-content style=\"fixed-case\">TEAE<\/jats:styled-content>s, systemic allergic reactions, or severe local allergic swellings in adults or children with asthma treated with grass SLIT\u2010tablet versus subjects without asthma in or outside of pollen season. There were 6\/120 asthma\u2010related <jats:styled-content style=\"fixed-case\">TRAE<\/jats:styled-content>s assessed as severe with grass SLIT\u2010tablet and 2\/60 with placebo, without a consistent trend among subjects with and without asthma (5 and 3 events, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>\/C subjects with reported well\u2010controlled mild asthma included in these studies, grass SLIT\u2010tablet did not increase <jats:styled-content style=\"fixed-case\">TEAE<\/jats:styled-content> frequency, severe local allergic swelling, or systemic allergic reactions versus subjects without asthma. There was no indication that treatment led to acute asthma worsening.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12560","type":"journal-article","created":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T04:56:08Z","timestamp":1418619368000},"page":"302-309","source":"Crossref","is-referenced-by-count":46,"title":["Safety of sublingual immunotherapy Timothy grass tablet in subjects with allergic rhinitis with or without conjunctivitis and history of asthma"],"prefix":"10.1111","volume":"70","author":[{"given":"J.","family":"Maloney","sequence":"first","affiliation":[{"name":"Merck &amp; Co., Inc. Whitehouse Station NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Durham","sequence":"additional","affiliation":[{"name":"Royal Brompton and Harefield Hospitals National Health Service Trust and Imperial College London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Skoner","sequence":"additional","affiliation":[{"name":"Allegheny General Hospital Pittsburgh PA USA"},{"name":"Temple University School of Medicine Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Dahl","sequence":"additional","affiliation":[{"name":"Allergy Centre Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bufe","sequence":"additional","affiliation":[{"name":"Experimental Pneumonology Ruhr\u2010University Bochum Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Bernstein Clinical Research Center Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Boys Town National Research Hospital Boys Town NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Waserman","sequence":"additional","affiliation":[{"name":"McMaster University Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Berman","sequence":"additional","affiliation":[{"name":"Allergy &amp; Asthma Specialists Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"White","sequence":"additional","affiliation":[{"name":"Institute for Asthma &amp; Allergy Wheaton MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kaur","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc. 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