{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:30:23Z","timestamp":1790505023225,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T00:00:00Z","timestamp":1429833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mastocytosis is a clonal disorder characterized by the proliferation and accumulation of mast cells (\n                    <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>\n                    ) in different tissues, with a preferential localization in skin and bone marrow (\n                    <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content>\n                    ). The excess of\n                    <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>\n                    in mastocytosis as well as the increased releasability of\n                    <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>\n                    may lead to a higher frequency and severity of immediate hypersensitivity reactions. Mastocytosis in adults is associated with a history of anaphylaxis in 22\u201349%. Fatal anaphylaxis has been described particularly following hymenoptera stings, but also occasionally after the intake of drugs such as nonsteroidal anti\u2010inflammatory drugs, opioids and drugs in the perioperative setting. However, data on the frequency of drug hypersensitivity in mastocytosis and vice versa are scarce and evidence for an association appears to be limited. Nevertheless, clonal\n                    <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>\n                    disorders should be ruled out in cases of severe anaphylaxis: basal serum tryptase determination, physical examination for cutaneous mastocytosis lesions, and clinical characteristics of anaphylactic reaction might be useful for differential diagnosis. In this position paper, the\n                    <jats:styled-content style=\"fixed-case\">ENDA<\/jats:styled-content>\n                    group performed a literature search on immediate drug hypersensitivity reactions in clonal\n                    <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>\n                    disorders using\n                    <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>\n                    , and Cochrane Library, reviewed and evaluated the literature in five languages using the\n                    <jats:styled-content style=\"fixed-case\">GRADE<\/jats:styled-content>\n                    system for quality of evidence and strength of recommendation.\n                  <\/jats:p>","DOI":"10.1111\/all.12617","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T09:40:16Z","timestamp":1427881216000},"page":"755-763","source":"Crossref","is-referenced-by-count":96,"title":["Drug hypersensitivity in clonal mast cell disorders:\n                    <scp>ENDA<\/scp>\n                    \/\n                    <scp>EAACI<\/scp>\n                    position paper"],"prefix":"10.1111","volume":"70","author":[{"given":"P.","family":"Bonadonna","sequence":"first","affiliation":[{"name":"Allergy Unit Azienda Ospedaliera Universitaria Intergrata of Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Pagani","sequence":"additional","affiliation":[{"name":"Medicine Ward Pieve di Coriano Hospital Azienda Ospedaliera Carlo Poma Mantova Mantova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Aberer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology Medizinische Universitat Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. B.","family":"Bil\u00f2","sequence":"additional","affiliation":[{"name":"Allergy Unit Department of Internal Medicine Ospedali Riuniti di Ancona Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Brockow","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Biederstein Technische Universit\u00e4t M\u00fcnchen Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Oude Elberink","sequence":"additional","affiliation":[{"name":"Department of Allergology GRIAC Research Institute University of Groningen University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Garvey","sequence":"additional","affiliation":[{"name":"Allergy Clinic Copenhagen University Hospital Gentofte Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Mosbech","sequence":"additional","affiliation":[{"name":"Allergy Clinic Copenhagen University Hospital Gentofte Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Romano","sequence":"additional","affiliation":[{"name":"Allergy Unit Complesso Integrato Columbus Rome and IRCCS Oasi Maria S.S. 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