{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:40:18Z","timestamp":1790516418935,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T00:00:00Z","timestamp":1430870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG-FOR729"],"award-info":[{"award-number":["DFG-FOR729"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The introduction of pegylated interferon (PEG\u2010<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>)\u2010\u03b1 in the treatment of chronic hepatitis C has led to an increase in sustained virological response. Despite reduced immunogenicity of the pegylated form in comparison with native interferon (<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>)\u2010\u03b1, a high frequency of adverse cutaneous reactions has been reported with pegylated<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b1. Here, we aimed to investigate the immunological mechanisms underlying pegylated<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b1\u2010induced drug eruptions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Hepatitis C patients suffering from drug eruptions in association with administration of pegylated interferons were enrolled in the study (<jats:italic>n<\/jats:italic>\u00a0=\u00a022). Subjects were tested for sensitivity to pegylated<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b1<jats:sub>2a<\/jats:sub>, pegylated<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b1<jats:sub>2b<\/jats:sub>, or ribavirin using intradermal, scratch, and\/or patch tests, as well as lymphocyte activation tests (<jats:styled-content style=\"fixed-case\">LAT<\/jats:styled-content>s). Skin biopsies obtained from pegylated<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b1\u2010associated exanthemas, as well as from localized inflammatory skin reactions at pegylated<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b1 injection sites, were analyzed for the expression of relevant chemokines by quantitative real\u2010time<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>and immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A subset of patients suffering from pegylated<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b1\u2010associated exanthemas displayed positive intradermal tests to<jats:styled-content style=\"fixed-case\">PEG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>s but not to conventional<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>(11\/22). In selected patients, this observation correlated with the presence of pegylated<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010specific T cells (3\/11). Chemokine profiles of inflammatory skin reactions at the injection sites reflected an<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b1\u2010signature, whereas lesional skin of exanthemas showed induction of<jats:styled-content style=\"fixed-case\">TH<\/jats:styled-content>2\u2010associated chemokines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate that specific sensitizations are one cause of exanthemas under therapy with<jats:styled-content style=\"fixed-case\">PEG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>s. Clinical proof\u2010of\u2010concept analyses demonstrate that affected patients may benefit from a switch to conventional,\u00a0nonpegylated drugs, enabling<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b1 therapy continuation without drug\u2010associated skin eruptions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12618","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T14:29:16Z","timestamp":1427898556000},"page":"775-783","source":"Crossref","is-referenced-by-count":17,"title":["Allergic sensitization to pegylated interferon\u2010\u03b1 results in drug eruptions"],"prefix":"10.1111","volume":"70","author":[{"given":"S.","family":"Meller","sequence":"first","affiliation":[{"name":"Department of Dermatology Medical Faculty Heinrich\u2010Heine\u2010University Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. A.","family":"Gerber","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical Faculty Heinrich\u2010Heine\u2010University Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kislat","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical Faculty Heinrich\u2010Heine\u2010University Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Hevezi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical Faculty Heinrich\u2010Heine\u2010University Duesseldorf Germany"},{"name":"Physiology and Biophysics University of California Irvine Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"G\u00f6bel","sequence":"additional","affiliation":[{"name":"Clinic of Gastroenterology, Hepatology and Infectiology Medical Faculty Heinrich\u2010Heine\u2010University Duesseldorf 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