{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:34:10Z","timestamp":1792625650309,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T00:00:00Z","timestamp":1429488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FOOD-CT-2004-506378"],"award-info":[{"award-number":["FOOD-CT-2004-506378"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2015,7]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Exposure to indoor allergens during early life may play a role in the development of the immune system and inception of asthma.<\/jats:p><\/jats:sec>Objective<\/jats:title>To describe the house dust mite (HDM<\/jats:styled-content>) allergen concentrations in bedroom dust during early life and to evaluate its associations with HDM<\/jats:styled-content> sensitization, wheezing, and asthma, from birth to school age, in 5 geographically spread European birth cohorts.<\/jats:p><\/jats:sec>Methods<\/jats:title>We included 4334 children from INMA<\/jats:styled-content>\u2010M<\/jats:styled-content>enorca (S<\/jats:styled-content>pain), BAMSE<\/jats:styled-content> (S<\/jats:styled-content>weden), LISA<\/jats:styled-content>plus and MAS<\/jats:styled-content> (G<\/jats:styled-content>ermany), and PIAMA<\/jats:styled-content>\u2010NHS<\/jats:styled-content> (the N<\/jats:styled-content>etherlands). Dust samples were collected from bedrooms during early life and analyzed for D<\/jats:styled-content>ermatophagoides pteronyssinus<\/jats:italic> (Der p1<\/jats:italic>) and Dermatophagoides farinae<\/jats:italic> (D<\/jats:styled-content>er f1<\/jats:italic>). HDM<\/jats:styled-content> concentrations were divided into four categories. Sensitization was determined by specific I<\/jats:styled-content>gE<\/jats:styled-content>. Wheezing and asthma information up to 8\/10\u00a0years was collected through questionnaires. We performed mixed\u2010effects logistic regression models and expressed associations as odds ratios with 95% confidence intervals.<\/jats:p><\/jats:sec>Results<\/jats:title>House dust mite concentrations varied across cohorts. Mean allergen concentrations were highest in INMA<\/jats:styled-content>\u2010Menorca (geometric mean (GM<\/jats:styled-content>) D<\/jats:styled-content>er p1\u00a0<\/jats:italic>=\u00a0<\/jats:italic>3.3\u00a0\u03bcg\/g) and LISA<\/jats:styled-content>plus (GM <\/jats:styled-content>D<\/jats:styled-content>er f1\u00a0<\/jats:italic>=\u00a0<\/jats:italic>2.1\u00a0\u03bcg\/g) and lowest in BAMSE<\/jats:styled-content> (GM <\/jats:styled-content>D<\/jats:styled-content>er p1\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.1\u00a0\u03bcg\/g, D<\/jats:styled-content>er f1\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.3\u00a0\u03bcg\/g). Moderate and high HDM<\/jats:styled-content> concentrations were significantly (P<\/jats:italic>\u2010values\u00a0<\u00a00.05) associated with 50\u201390% higher prevalence of HDM<\/jats:styled-content> sensitization. No significant associations were observed with respiratory outcomes.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our study based on geographically spread regions, a large sample size, and a wide range of allergen concentration shows that HDM<\/jats:styled-content> allergen concentrations vary across regions and that exposure during early life plays a role in the development of allergic sensitization but not in the development of respiratory outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12626","type":"journal-article","created":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T07:38:26Z","timestamp":1428478706000},"page":"820-827","source":"Crossref","is-referenced-by-count":48,"title":["Early\u2010life house dust mite allergens, childhood mite sensitization, and respiratory outcomes"],"prefix":"10.1111","volume":"70","author":[{"given":"L.","family":"Casas","sequence":"first","affiliation":[{"name":"Department of Public Health and Primary Care Centre for Environment and Health KU Leuven Leuven Belgium"},{"name":"Centre for Research in Environmental Epidemiology (CREAL) Barcelona Spain"},{"name":"CIBER Epidemiologia y Salud P\u00fablica (CIBERESP) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sunyer","sequence":"additional","affiliation":[{"name":"Centre for Research in Environmental Epidemiology (CREAL) Barcelona Spain"},{"name":"CIBER Epidemiologia y Salud P\u00fablica (CIBERESP) Barcelona Spain"},{"name":"Hospital del Mar Medical Research Institute (IMIM) Barcelona Spain"},{"name":"Universitat Pompeu Fabra (UPF) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Tischer","sequence":"additional","affiliation":[{"name":"Helmholtz Zentrum M\u00fcnchen German Research Centre for Environmental Health Institute of Epidemiology I Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Gehring","sequence":"additional","affiliation":[{"name":"Division of Environmental Epidemiology Institute for Risk Assessment Sciences Utrecht University Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wickman","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education S\u00f6dersjukhuset Karolinska Institutet Stockholm Sweden"},{"name":"Sach's Children's Hospital Stockholm Sweden"},{"name":"Institute for Environmental Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Garcia\u2010Esteban","sequence":"additional","affiliation":[{"name":"Centre for Research in Environmental Epidemiology (CREAL) Barcelona Spain"},{"name":"CIBER Epidemiologia y Salud P\u00fablica (CIBERESP) Barcelona Spain"},{"name":"Hospital del Mar Medical Research Institute (IMIM) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Department of Environmental Immunology FZ\u2013Helmholtz Centre for Environmental Research Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Kull","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education S\u00f6dersjukhuset Karolinska Institutet Stockholm Sweden"},{"name":"Sach's Children's Hospital Stockholm Sweden"},{"name":"Institute for Environmental Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Reich","sequence":"additional","affiliation":[{"name":"Institute of Social Medicine, Epidemiology and Health Economics Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Lau","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr P\u00e4diatrie m. S. Pneumologie und Immunologie Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wijga","sequence":"additional","affiliation":[{"name":"Centre for Nutrition, Prevention and Health Services National Institute for Public Health and the Environment (RIVM) Bilthoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Ant\u00f3","sequence":"additional","affiliation":[{"name":"Centre for Research in Environmental Epidemiology (CREAL) Barcelona Spain"},{"name":"CIBER Epidemiologia y Salud P\u00fablica (CIBERESP) Barcelona Spain"},{"name":"Hospital del Mar Medical Research Institute (IMIM) Barcelona Spain"},{"name":"Universitat Pompeu Fabra (UPF) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. S.","family":"Nawrot","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care Centre for Environment and Health KU Leuven Leuven Belgium"},{"name":"Centre for Environmental Sciences Hasselt University Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Heinrich","sequence":"additional","affiliation":[{"name":"Helmholtz Zentrum M\u00fcnchen German Research Centre for Environmental Health Institute of Epidemiology I Neuherberg Germany"},{"name":"Comprehensive Pneumology Center Munich (CPC\u2010M) German Center for Lung Research (DZL) Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Keil","sequence":"additional","affiliation":[{"name":"Institute of Social Medicine, Epidemiology and Health Economics Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"},{"name":"Institute of Clinical Epidemiology and Biometry University of Wuerzburg Wuerzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Torrent","sequence":"additional","affiliation":[{"name":"Area de Salud de Menorca IB\u2010SALUT Menorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.02.035"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.01021.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63612-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(89)90300-X"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)80009-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.04.059"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199008233230802"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02842-7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200607-916OC"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200310-1348OC"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.04.018"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02739.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.13.s.15.11.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.04.004"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-202150"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.03.029"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200401-083OC"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2012.07.005"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.019877"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00196.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.2002.02081.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03424.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.12020315"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01167.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr054"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.13.s.15.10.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.02322001"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.1994.tb00343.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys231"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.99.13358599"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.021100693"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-0668.2003.00207.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2012.03993.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/143.5_Pt_1.983"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01079.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1998.tb05001.x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.01.00096801"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.04.007"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00036.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.04.060"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02712.x"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-12-103"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007302"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00060214"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2003.01807.x"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.12626","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.12626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T05:12:24Z","timestamp":1696396344000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.12626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,20]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/all.12626"],"URL":"https:\/\/doi.org\/10.1111\/all.12626","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,20]]}}}