{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T02:15:14Z","timestamp":1787451314435,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T00:00:00Z","timestamp":1431907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000912","name":"March of Dimes Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004954","name":"Augustinus Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC-2009-StG-243149"],"award-info":[{"award-number":["ERC-2009-StG-243149"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","award":["DNRF108"],"award-info":[{"award-number":["DNRF108"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011054","name":"DANIDA","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011054","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008392","name":"Danish Medical Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"crossref"}]},{"name":"EU","award":["ICA4-CT-2002-10053"],"award-info":[{"award-number":["ICA4-CT-2002-10053"]}]},{"name":"Fonden for L\u00e6gevidenskabens Fremme"},{"name":"Ville Heise Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Neonatal vitamin A supplementation (\n NVAS<\/jats:styled-content>\n ) is currently being considered as policy in countries at risk of deficiency. A previous study suggested that\n NVAS<\/jats:styled-content>\n may be associated with increased atopy. We examined the effect of\n NVAS<\/jats:styled-content>\n on atopy by conducting long\u2010term follow\u2010up of a previous randomized controlled trial in Guinea\u2010Bissau.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In 2002\u20132004, we randomized 4345 normal birthweight neonates to\n NVAS<\/jats:styled-content>\n (50\u00a0000\u00a0IU retinyl palmitate) or placebo together with their Bacillus Calmette\u2013Gu\u00e9rin vaccination. In 2013, we visited the 1692 (39%) children now aged 8\u201310\u00a0years who were still living in the study area, and 1478 (87%) were found at home. Provided consent, a skin prick test was performed, and history of allergic symptoms was recorded. Associations of\n NVAS<\/jats:styled-content>\n and atopy (defined as skin prick test reaction of \u22653\u00a0mm) were analysed using binomial regression.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the 1430 children with a valid skin prick test, 228 (16%) were positive (more boys (20%) than girls (12%),\n P<\/jats:italic>\n \u2010value\u00a0<\u00a00.0001).\n NVAS<\/jats:styled-content>\n did not increase the overall risk of atopy (\n RR<\/jats:styled-content>\n 1.10 [95%\n CI<\/jats:styled-content>\n 0.87\u20131.40]). However,\n NVAS<\/jats:styled-content>\n was associated with significantly increased risk among females (\n RR<\/jats:styled-content>\n 1.78 [1.17\u20132.72]) but not among males (0.86 [0.64\u20131.15],\n P<\/jats:italic>\n \u2010value for interaction between\n NVAS<\/jats:styled-content>\n and gender\u00a0=\u00a00.005). Furthermore,\n NVAS<\/jats:styled-content>\n was associated with increased risk of wheezing among females (\n RR<\/jats:styled-content>\n 1.80 [1.03\u20133.17], but not among males,\n P<\/jats:italic>\n \u2010value for interaction\u00a0=\u00a00.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The study corroborated previous observations;\n NVAS<\/jats:styled-content>\n was associated with increased risk of atopy and wheezing, in this study only among females. Further studies on\n NVAS<\/jats:styled-content>\n and atopy are warranted.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/all.12641","type":"journal-article","created":{"date-parts":[[2015,5,2]],"date-time":"2015-05-02T09:12:53Z","timestamp":1430557973000},"page":"985-994","source":"Crossref","is-referenced-by-count":30,"title":["Neonatal vitamin A supplementation associated with increased atopy in girls"],"prefix":"10.1111","volume":"70","author":[{"given":"S.","family":"Aage","sequence":"first","affiliation":[{"name":"Bandim Health Project Bissau Guinea\u2010Bissau"},{"name":"Research Center for Vitamins and Vaccines (CVIVA) Statens Serum Institut Copenhagen S Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Kiraly","sequence":"additional","affiliation":[{"name":"Gastro and Food Allergy Research Group Murdoch Children's Research Institute Parkville Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Da Costa","sequence":"additional","affiliation":[{"name":"Bandim Health Project Bissau Guinea\u2010Bissau"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Byberg","sequence":"additional","affiliation":[{"name":"Bandim Health Project Bissau Guinea\u2010Bissau"},{"name":"Research Center for Vitamins and Vaccines (CVIVA) Statens Serum Institut Copenhagen S Denmark"},{"name":"OPEN, Institute of Clinical Research University of Southern Denmark\/Odense University Hospital Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bjerregaard\u2010Andersen","sequence":"additional","affiliation":[{"name":"Bandim Health Project Bissau Guinea\u2010Bissau"},{"name":"Research Center for Vitamins and Vaccines (CVIVA) Statens Serum Institut Copenhagen S Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. B.","family":"Fisker","sequence":"additional","affiliation":[{"name":"Bandim Health Project Bissau Guinea\u2010Bissau"},{"name":"Research Center for Vitamins and Vaccines (CVIVA) Statens Serum Institut Copenhagen S Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Aaby","sequence":"additional","affiliation":[{"name":"Bandim Health Project Bissau Guinea\u2010Bissau"},{"name":"Research Center for Vitamins and Vaccines (CVIVA) Statens Serum Institut Copenhagen S Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. S.","family":"Benn","sequence":"additional","affiliation":[{"name":"Bandim Health Project Bissau Guinea\u2010Bissau"},{"name":"Research Center for Vitamins and Vaccines (CVIVA) Statens Serum Institut Copenhagen S Denmark"},{"name":"OPEN, Institute of Clinical Research University of Southern Denmark\/Odense University Hospital Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,18]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Guideline: Vitamin A supplementation in infants and children 6\u201359\u00a0months of age","author":"WHO","year":"2011"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/ajcn\/62.1.143","article-title":"Mortality of infants <6\u00a0month of age supplemented with vitamin A: a randomized, double\u2010masked trial in Nepal","volume":"62","author":"West KP","year":"1995","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7409.254"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60891-6"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3448"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70359-1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.114.192674"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39542.509444.AE"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c1101"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60880-1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/500366"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn.81.2.454"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61731-1"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12216"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/86.4.1032"},{"key":"e_1_2_9_17_1","first-page":"10","article-title":"The international study of asthma and allergies in childhood (ISAAC): phase three rationale and methods","volume":"9","author":"Ellwood P","year":"2005","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_2_9_18_1","unstructured":"ISAAC.Core questionnaire in English.ISAAC Steering Committee2012(cited 2015 Jan 15): Available fromhttp:\/\/isaac.auckland.ac.nz\/phases\/phasethree\/corequestionnaire.pdf."},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c6495"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-13-22"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03206-2"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.155.3.401"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-13-190"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00006911"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-9-16"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22417"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxg101"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.3.1834"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu232"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2394"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1430031"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.12641","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.12641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T20:36:50Z","timestamp":1696451810000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.12641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,18]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/all.12641"],"URL":"https:\/\/doi.org\/10.1111\/all.12641","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,18]]}}}