{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:09:16Z","timestamp":1793333356890,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,6,9]],"date-time":"2015-06-09T00:00:00Z","timestamp":1433808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"RedRespira-ISCIII","award":["03\/11"],"award-info":[{"award-number":["03\/11"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Near\u2010fatal asthma (<jats:styled-content style=\"fixed-case\">NFA<\/jats:styled-content>) is a heterogeneous clinical entity and several profiles of patients have been described according to different clinical, pathophysiological and histological features. However, there are no previous studies that identify in a unbiased way \u2013 using statistical methods such as clusters analysis \u2013 different phenotypes of NFA. Therefore, the aim of the present study was to identify and to characterize phenotypes of near fatal asthma using a cluster analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Over a period of 2\u00a0years, 33 Spanish hospitals enrolled 179 asthmatics admitted for an episode of NFA. A cluster analysis using two\u2010steps algorithm was performed from data of 84 of these cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis defined three clusters of patients with <jats:styled-content style=\"fixed-case\">NFA<\/jats:styled-content>: cluster 1, the largest, including older patients with clinical and therapeutic criteria of severe asthma; cluster 2, with an high proportion of respiratory arrest (68%), impaired conciousness level (82%) and mechanical ventilation (93%); and cluster 3, which included younger patients, characterized by an insufficient anti\u2010inflammatory treatment and frequent sensitization to <jats:italic>Alternaria alternata<\/jats:italic> and soybean.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results identify specific asthma phenotypes involved in <jats:styled-content style=\"fixed-case\">NFA<\/jats:styled-content>, confirming in part previous findings observed in studies with a clinical approach. The identification of patients with a specific <jats:styled-content style=\"fixed-case\">NFA<\/jats:styled-content> phenotype could suggest interventions to prevent future severe asthma exacerbations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12654","type":"journal-article","created":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T15:38:14Z","timestamp":1432309094000},"page":"1139-1147","source":"Crossref","is-referenced-by-count":28,"title":["Identification and characterization of near\u2010fatal asthma phenotypes by cluster analysis"],"prefix":"10.1111","volume":"70","author":[{"given":"J.","family":"Serrano\u2010Pariente","sequence":"first","affiliation":[{"name":"Pneumology Department Hospital Comarcal d'Inca Balearic Islands Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Rodrigo","sequence":"additional","affiliation":[{"name":"Emergency Department Hospital Central de las Fuerzas Armadas Montevideo Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Fiz","sequence":"additional","affiliation":[{"name":"Pneumology Department Hospital Germans Trias i Pujol de Badalona (Barcelona) Institut de Bioingenieria de Catalunya (IBEC) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Crespo","sequence":"additional","affiliation":[{"name":"Pneumology Department Hospital de la Santa Creu i de Sant Pau de Barcelona Institut d'Investigaci\u00f3 Biom\u00e9dica Sant Pau (IIB Sant Pau) Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Plaza","sequence":"additional","affiliation":[{"name":"Pneumology Department Hospital de la Santa Creu i de Sant Pau de Barcelona Institut d'Investigaci\u00f3 Biom\u00e9dica Sant Pau (IIB Sant Pau) Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the High Risk Asthma Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,9]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization.WHO Programmes and projects. 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Universit\u00e4t Erlangen\u2010N\u00fcrnberg Wirtschafts\u2010 und Sozialwissenschaftliche Fakult\u00e4t Sozialwissenschaftliches Institut Lehrstuhl f\u00fcr Soziologie (Ed.): N\u00fcrnberg 2004 (Arbeits\u2010 und Diskussionspapiere\/Universit\u00e4t Erlangen\u2010 N\u00fcrnberg Sozialwissenschaftliches Institut Lehrstuhl f\u00fcr Soziologie 2004\u20102). Available at:http:\/\/nbn-resolving.de\/urn:nbn:de:0168-ssoar-327153(Last accessed: February 2015)."},{"key":"e_1_2_9_22_1","unstructured":"Global Initiative for Asthma.Global Strategy for Asthma Management and Prevention. NHLBI\/WHO workshop report. 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