{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T13:00:40Z","timestamp":1773493240767,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T00:00:00Z","timestamp":1435104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The utility of measuring histamine and prostaglandin metabolites in the urine of patients with mastocytosis has not been critically examined in a large series of patients. This study examined the relationship between the extent of increase in urinary excretion of 11\u03b2\u2010prostaglandinF2<jats:sub>\u03b1<\/jats:sub> and N\u2010methyl histamine, with serum tryptase, whole blood serotonin, and bone marrow findings including morphology, percentage involvement, and abnormal mast cell phenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective analysis of 90 patients who were continuously enrolled in the study for a period of 6\u00a0years (2008\u20132014). We recorded serum tryptase, whole blood serotonin, levels of urinary mast cell metabolites 11\u03b2\u2010prostaglandinF2\u03b1 and N\u2010methyl histamine (<jats:styled-content style=\"fixed-case\">NMH<\/jats:styled-content>), and bone marrow findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Urinary mast cell metabolites 11\u03b2\u2010prostaglandinF2\u03b1 and N\u2010methyl histamine correlated with levels of serum tryptase, mast cell burden in the bone marrow, the presence of mast cell aggregates, and atypical mast cells on bone marrow biopsy. Whole blood serotonin did not have a significant correlation with the serum tryptase or mast cell burden in the bone marrow. Urinary <jats:styled-content style=\"fixed-case\">NMH<\/jats:styled-content> was significantly different between <jats:italic>c\u2010kit<\/jats:italic> D816V\u2010positive and <jats:italic>c\u2010kit<\/jats:italic> D816V\u2010negative patients, while 11\u03b2\u2010prostaglandinF2\u03b1 was not. Urinary 11\u03b2\u2010prostaglandinF2\u03b1 24\u2010h excretion &gt;3500\u00a0ng and <jats:styled-content style=\"fixed-case\">NMH<\/jats:styled-content> levels &gt;400\u00a0\u03bcg\/gm Cr corresponded with the high degree of bone marrow biopsies positive for atypical mast cells, the presence of aggregates, and <jats:italic>c\u2010kit<\/jats:italic> mutation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Easily obtained and quantified urinary metabolites of histamine (greater than twice the upper limit of normal) and prostaglandin D<jats:sub>2<\/jats:sub> (&gt;3.4 times the upper limit of normal) correlate well with bone marrow findings of mastocytosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12668","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T14:48:27Z","timestamp":1434725307000},"page":"1230-1238","source":"Crossref","is-referenced-by-count":27,"title":["Urinary 11\u03b2\u2010<scp>PGF<\/scp>2\u03b1 and N\u2010methyl histamine correlate with bone marrow biopsy findings in mast cell disorders"],"prefix":"10.1111","volume":"70","author":[{"given":"R.","family":"Divekar","sequence":"first","affiliation":[{"name":"Division of Allergic Diseases and the Mayo Clinic Program for Mast Cell and Eosinophil Disorders Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Butterfield","sequence":"additional","affiliation":[{"name":"Division of Allergic Diseases and the Mayo Clinic Program for Mast Cell and Eosinophil Disorders Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(01)00038-8"},{"key":"e_1_2_10_3_1","volume-title":"Mastocytosis","author":"Valent PHH","year":"2001"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190400010775"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000059404"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.11.018"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198706253162603"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328760"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2006.05.010"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","unstructured":"Quintas\u2010CardamaASM CortesJE KantarjianHM VerstovsekS.Change in mast cell bone marrow burden and in serum tryptase level are not accurate markers of response in patients with systemic mastocytosis. 2010.","DOI":"10.1182\/blood.V116.21.3073.3073"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02184.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2006.05.002"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(89)80398-5"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12555351"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198312293092603"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","unstructured":"GranerusG LonnqvistB RoupeG.No relationship between histamine release measured as metabolite excretion in the urine and serum levels of mast cell specific tryptase in mastocytosis. 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