{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:14:01Z","timestamp":1791274441049,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Finnish association of otorhinolaryngology and head and neck surgery"},{"DOI":"10.13039\/100008723","name":"Finnish Medical Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Helsinki University Central Hospital Research Fund"},{"DOI":"10.13039\/501100004012","name":"Jane and Aatos Erkko Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004012","id-type":"DOI","asserted-by":"crossref"}]},{"name":"V\u00e4in\u00f6 and Laina Kivi Foundation"},{"DOI":"10.13039\/100010114","name":"Yrj\u00f6 Jahnsson Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010114","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is a large global variation in the sensitization pattern and its association with allergic diseases. In temperate and tropical urban environments, mite monosensitization can be the predominant cause of allergic airway diseases, whereas in other environments, polysensitization is more typical. Sensitization to mite allergens associates with asthma. However, it is suggested that mite sensitization might play a minor role in Northern Europe. The aim of the study was to analyze how sensitization pattern affects the asthma risk in Finnish adults, with a special focus on mites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A population\u2010based case\u2013control data (<jats:italic>N<\/jats:italic>\u00a0=\u00a0523) from Finnish adult asthma patients with one or two matched controls were used. Asthma was diagnosed based on a typical history of asthmatic symptoms and lung function tests. The allergic sensitization was determined based on skin prick test (<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>) of five mites, three molds, and nine other aeroallergens. Information on demographics was obtained by a questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proportion of sensitization to any allergen was 55% in the asthma group and 39% in the control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.06, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.35\u20133.14). Sensitization to animal dander, pollen, or <jats:italic>Aspergillus fumigatus<\/jats:italic> was associated with asthma. Polysensitization to more than one allergen types and the number of <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>\u2010positive reactions associated with asthma, whereas sensitization to only one allergen type was not associated with asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The large number of sensitizations to several types of allergens distinguishes subjects with asthma. Mite sensitization had little independent association with asthma in Finland.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.12670","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T18:04:26Z","timestamp":1434737066000},"page":"1112-1120","source":"Crossref","is-referenced-by-count":43,"title":["Sensitization pattern affects the asthma risk in <scp>F<\/scp>innish adult population"],"prefix":"10.1111","volume":"70","author":[{"given":"S.","family":"Toppila\u2010Salmi","sequence":"first","affiliation":[{"name":"Haartman Institute University of Helsinki Helsinki Finland"},{"name":"Department of Allergy University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Huhtala","sequence":"additional","affiliation":[{"name":"School of Health Sciences University of Tampere Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Karjalainen","sequence":"additional","affiliation":[{"name":"Allergy Centre Tampere University Hospital Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Renkonen","sequence":"additional","affiliation":[{"name":"Haartman Institute University of Helsinki Helsinki Finland"},{"name":"HUSLAB Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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