{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:16:04Z","timestamp":1790471764517,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T00:00:00Z","timestamp":1438819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Allergic bronchopulmonary aspergillosis (<jats:styled-content style=\"fixed-case\">ABPA<\/jats:styled-content>) is characterized by an allergic immunological response to <jats:italic>Aspergillus fumigatus<\/jats:italic>. In this study, we investigated whether certain <jats:italic>Aspergillus<\/jats:italic> antigens are more allergenic than others, as was postulated previously. We stimulated peripheral blood mononuclear cells from patients with <jats:styled-content style=\"fixed-case\">ABPA<\/jats:styled-content> with the classically described <jats:italic>A. fumigatus<\/jats:italic> allergens Aspf1, Aspf2, Aspf3, and Aspf4, as well as two other <jats:italic>Aspergillus<\/jats:italic> antigens, Crf1 and Catalase1. Activated <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+ T cells displayed a T helper 2 phenotype with the production of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104 in response to stimulation with several of these different antigens. Immune responses were not limited to the classically described <jats:italic>A. fumigatus<\/jats:italic> allergens. In healthy individuals, we demonstrated a similar recognition profile to the different antigens, but in contrast the activated <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+ T cells exerted a T helper 1 phenotype and mainly produced <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 after stimulation with <jats:italic>A. fumigatus<\/jats:italic> antigens. In conclusion, irrespective of the <jats:italic>A. fumigatus<\/jats:italic> antigen, the T\u2010cell immune response in patients with <jats:styled-content style=\"fixed-case\">ABPA<\/jats:styled-content> is skewed to a T helper 2 cytokine secretion profile.<\/jats:p>","DOI":"10.1111\/all.12688","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T15:18:50Z","timestamp":1436887130000},"page":"1336-1339","source":"Crossref","is-referenced-by-count":20,"title":["T helper 2 response in allergic bronchopulmonary aspergillosis is not driven by specific <i>Aspergillus<\/i> antigens"],"prefix":"10.1111","volume":"70","author":[{"given":"H.","family":"Jolink","sequence":"first","affiliation":[{"name":"Department of Hematology Leiden University Medical Center Leiden the Netherlands"},{"name":"Department of Infectious Diseases Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Hematology Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. N. A.","family":"Willems","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. T.","family":"van Dissel","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. H. F.","family":"Falkenburg","sequence":"additional","affiliation":[{"name":"Department of Hematology Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. H. M.","family":"Heemskerk","sequence":"additional","affiliation":[{"name":"Department of Hematology Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,6]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"936","article-title":"Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis in patients with bronchial asthma: systematic review and meta\u2010analysis","volume":"13","author":"Agarwal R","year":"2009","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/376525"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2010.514301"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00200-10"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(88)90995-5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1398-9995.2003.00310.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118675"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/ai.1994.v94.a54891"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/clim.2001.5056"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202221"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit237"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.098830"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.12688","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.12688","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T23:56:07Z","timestamp":1696377367000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.12688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,6]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/all.12688"],"URL":"https:\/\/doi.org\/10.1111\/all.12688","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,6]]}}}