{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:35:40Z","timestamp":1780670140120,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,17]],"date-time":"2015-09-17T00:00:00Z","timestamp":1442448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P23350\u2010B11"],"award-info":[{"award-number":["P23350\u2010B11"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["F4605"],"award-info":[{"award-number":["F4605"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) patients mount IgE antibody responses to a variety of environmental allergens and also to autoantigens. We analyzed serum samples from four <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> patients who had received oral cyclosporine A (CyA) treatment for up to 17 months regarding IgE autoreactivity to nitrocellulose\u2010blotted human epithelial cell extracts and IgE levels to environmental allergens by quantitative ImmunoCap measurements. Skin inflammation was assessed by <jats:styled-content style=\"fixed-case\">SCORAD<\/jats:styled-content>. During full\u2010dose treatment, a strong reduction in T\u2010cell\u2010mediated skin symptoms was observed which reappeared when CyA treatment was reduced or stopped. The intensity of IgE autoreactivity seemed to follow skin inflammation as it was reduced during full\u2010dose treatment and increased upon inflammation. Interestingly, IgE levels to exogenous allergens were boosted by allergen exposure, declined thereafter, and seemed to be unaffected by CyA. Our data thus indicate that allergen\u2010specific IgE production is boosted by allergen contact and cannot be reduced by CyA\u2010mediated T\u2010cell suppression.<\/jats:p>","DOI":"10.1111\/all.12711","type":"journal-article","created":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T04:12:23Z","timestamp":1438315943000},"page":"115-118","source":"Crossref","is-referenced-by-count":19,"title":["IgE responses to exogenous and endogenous allergens in atopic dermatitis patients under long\u2010term systemic cyclosporine A treatment"],"prefix":"10.1111","volume":"71","author":[{"given":"S.","family":"Lucae","sequence":"first","affiliation":[{"name":"Division of Immunopathology Department of Pathophysiology and Allergy Research Center for Pathophysiology, Infectiology and Immunology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Schmid\u2010Grendelmeier","sequence":"additional","affiliation":[{"name":"Department of Dermatology Allergy Unit University Hospital Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"W\u00fcthrich","sequence":"additional","affiliation":[{"name":"Department of Dermatology Allergy Unit University Hospital Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Kraft","sequence":"additional","affiliation":[{"name":"Division of Immunopathology Department of Pathophysiology and Allergy Research Center for Pathophysiology, Infectiology and Immunology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Valenta","sequence":"additional","affiliation":[{"name":"Division of Immunopathology Department of Pathophysiology 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